ID A0A031LP74_9CREN Unreviewed; 664 AA.
AC A0A031LP74;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=CM19_05655 {ECO:0000313|EMBL:EZQ06857.1};
OS Candidatus Acidianus copahuensis.
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Acidianus.
OX NCBI_TaxID=1160895 {ECO:0000313|EMBL:EZQ06857.1, ECO:0000313|Proteomes:UP000024332};
RN [1] {ECO:0000313|EMBL:EZQ06857.1, ECO:0000313|Proteomes:UP000024332}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ALE1 {ECO:0000313|EMBL:EZQ06857.1,
RC ECO:0000313|Proteomes:UP000024332};
RA Urbieta M.S., Rascovan N., Castro C., Revale S., Giaveno M.A.,
RA Vazquez M.P., Donati E.R.;
RT "Draft genome sequence of the novel thermoacidophilic archaea Acidianus
RT copahuensis ALE1 strain, isolated from Copahue volcanic area in Neuquen
RT Argentina.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EZQ06857.1}.
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DR EMBL; JFZT01000039; EZQ06857.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A031LP74; -.
DR STRING; 1160895.CM19_05655; -.
DR OrthoDB; 30963at2157; -.
DR Proteomes; UP000024332; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005739; TopoI_arch.
DR InterPro; IPR006171; TOPRIM_domain.
DR NCBIfam; TIGR01057; topA_arch; 1.
DR PANTHER; PTHR11390:SF26; DNA TOPOISOMERASE 1; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:EZQ06857.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Reference proteome {ECO:0000313|Proteomes:UP000024332};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029};
KW Zinc {ECO:0000256|ARBA:ARBA00022771};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 8..144
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 664 AA; 76010 MW; 1FC7B57040B53B06 CRC64;
MSCSPKDYTL LIAEKPKAAK KIVEAFSKYQ QCNKGKAYYW IVRWNGSPVV IASAVGHLFD
LNGKSGFPVF EAEWRPIYEI NKKAYYTKKY YDLLRWLSSN AKQFINACDY DIEGSVIGYM
IIKTFGDLRK AKRMKYSTLT KQEIITAIGD LQPLDIYMVE AGIARHLVDW IWGINVSRAL
MKAVKSATSK RIILSAGRVQ SPSLIQIIKN DIDRSLFVPL PYFKIRVKLD LGKEIYAYLD
QDFENKEEAK SVARRIKKEE LKVEEVKQAD VRIPRPVPFN LGDLQVESGR FFGFSPYKTE
RLAEELYLNG MISYPRTNSQ KIPPSINVGE IIRGLREGPL KKYVQVFDSI VAEGPRIRQG
QRDDPAHPAI YPTGYFTRVS KDAYRLYDLI VRRFLASASL DAIVRKQDIL LRFANGYTLS
VGVQSVIEKG WTLIYPRDLK SEDLFNVKKG DKVGVLGVNV VMYTTKPSVG LSRISLLKWM
EESKIGTEAT RGKIIETLFL RKYVKLKGGY IIPTTLGLTV GEVLDYYFRD LTSVKMTSEM
ESELELIKYG KKNKDDVIKE VKERISKQVE GFAEKEVGEK IAKGLGLIQY KKCAYCDLEV
EKDGLCKYHR MALAQLEKIK IIWEDRSAIS EEEAIKRIAK LKTTGKLIKD IIENKWKDDV
RHAR
//
