ID A0A031LW43_9CREN Unreviewed; 567 AA.
AC A0A031LW43;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=CM19_01420 {ECO:0000313|EMBL:EZQ11373.1};
OS Candidatus Acidianus copahuensis.
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Acidianus.
OX NCBI_TaxID=1160895 {ECO:0000313|EMBL:EZQ11373.1, ECO:0000313|Proteomes:UP000024332};
RN [1] {ECO:0000313|EMBL:EZQ11373.1, ECO:0000313|Proteomes:UP000024332}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ALE1 {ECO:0000313|EMBL:EZQ11373.1,
RC ECO:0000313|Proteomes:UP000024332};
RA Urbieta M.S., Rascovan N., Castro C., Revale S., Giaveno M.A.,
RA Vazquez M.P., Donati E.R.;
RT "Draft genome sequence of the novel thermoacidophilic archaea Acidianus
RT copahuensis ALE1 strain, isolated from Copahue volcanic area in Neuquen
RT Argentina.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EZQ11373.1}.
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DR EMBL; JFZT01000015; EZQ11373.1; -; Genomic_DNA.
DR RefSeq; WP_048098617.1; NZ_JFZT01000015.1.
DR AlphaFoldDB; A0A031LW43; -.
DR STRING; 1160895.CM19_01420; -.
DR OrthoDB; 8639at2157; -.
DR Proteomes; UP000024332; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022932};
KW Reference proteome {ECO:0000313|Proteomes:UP000024332};
KW Transferase {ECO:0000256|ARBA:ARBA00022932}.
FT DOMAIN 230..389
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 567 AA; 65252 MW; 6012805AD175E15D CRC64;
MEGYVVDALP IHGGVTLVLD GFRKLKVKTT FPIYVITRDP EKVMEHPAVL YYEKEKWKDL
DGKEVALYRF ELSDMEAYYY IKKRLQVVNE IPTVMSQTLS RIGALPFRKV KVEGKVEEMY
PEEFPTISYA FITPTNWYGP SPEGKTYFAI VNGKRIQGKL DDLDLRVDVA ECYGIACDKV
TASVKIKSKS APVSIKGLIE WSLVSKTLLR ELEGATIGKV LTTNEAWIAL KRKVIIPKVV
PRVEKLRTLN DIIASDKGGL VVFPKLGCYD NVSQLDFSSM YPSIIVKYNI SAETVDTCED
LKTEIGHSIC LKERGIVPEA LEWLVKRKED LKRVDEERSD AIKWILVASF GYLGYRNSRF
GKIEAYELVT YFARKTLREA IELAREHKVD VLHGIVDSMI VKGDRVEDLI NDIESKTGLR
MKEEKMDWVI LFPRKDGMPY PMRYLGKLNG GKMKVKGLVR ENMPNVIKDF LEEAVDRMSK
ARNCKEVEEI RSEVEEIMEK YKTRIINGRK KQDYVMWVKG IPYIRGVRGF YIAERGYLGR
DVNYYLDFLR RQFEVLYGVV NGVPNPR
//
