ID A0A037ZPD6_9RHOB Unreviewed; 1814 AA.
AC A0A037ZPD6;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Apple domain-containing protein {ECO:0000259|PROSITE:PS50948};
GN ORFNames=ACMU_02500 {ECO:0000313|EMBL:KAJ57393.1};
OS Actibacterium mucosum KCTC 23349.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Actibacterium.
OX NCBI_TaxID=1454373 {ECO:0000313|EMBL:KAJ57393.1, ECO:0000313|Proteomes:UP000026249};
RN [1] {ECO:0000313|EMBL:KAJ57393.1, ECO:0000313|Proteomes:UP000026249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 23349 {ECO:0000313|EMBL:KAJ57393.1,
RC ECO:0000313|Proteomes:UP000026249};
RA Arahal D.R., Shao Z., Lai Q., Pujalte M.J.;
RT "Draft Genome Sequence of Actibacterium mucosum KCTC 23349, a Marine
RT Alphaproteobacterium with Complex Ionic Requirements Isolated from
RT Mediterranean Seawater at Malvarrosa Beach, Valencia, Spain.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ57393.1}.
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DR EMBL; JFKE01000001; KAJ57393.1; -; Genomic_DNA.
DR RefSeq; WP_035255700.1; NZ_JFKE01000001.1.
DR STRING; 1454373.ACMU_02500; -.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000026249; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR CDD; cd01100; APPLE_Factor_XI_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR InterPro; IPR026284; A2-macglob_dom_prot_bac.
DR InterPro; IPR049120; A2M_bMG2.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR000177; Apple.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF21142; A2M_bMG2; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF14295; PAN_4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR PIRSF; PIRSF038980; A2M_bac; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM00223; APPLE; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS50948; PAN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000026249};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1814
FT /note="Apple domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001564548"
FT DOMAIN 26..110
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
SQ SEQUENCE 1814 AA; 194333 MW; 745D691DDBC89C36 CRC64;
MRKYFSIFTI LAAMAAPVQA QDNGFVPERH IAISRDVDFP GADIRSLFDT TLEACQRACL
SDSSCVAFTY NTRSNSCFPK SAVGGRESYV GALSAIVTPT SDAVIGQASA RAAELDFLQP
RDLKAAFDFA SGLSRRHYVN DWTAPDLVQG GRNAQAAENF ENARRFYGSA LTFLDSADLW
VDYAAMSLKM AEAQNSNKRS LRNDALSASV NAYLRGANPQ TRASALLTMA EALEELGRGR
TSLPALRLAE ANAPRDDVLR ALDRAIGLFG FRVSSHNVNV RGPEPQMCAD FSQDLVPAGV
DYGAFVRLPE SGMSVNHNDT QVCVTGLTHG ERYRVTFRAG LPSARGEVTD KDVEITFYVP
DRPQQLRFAG RSYVLPKLGD AALPITSVNV AEADLRLRRV SDRNILRALQ EGYFGEQLSE
WRENQFANDV AEEVWEGTAV LQNTLNRDVT TRLPMGDVIG DLPAGIYTLT AAIPGTDPYE
FPPATQWFVI SDLGLSSVAG NDGLHVFVRS LATAEASADV QVSLLSRGNR VLAETATDAD
GYARFDPGLL RGRGGAAPAM IVAQQGEEDL VFLSLTDPGF DLSDRGVEGR APAGPVDVFV
STDRGAYRAG ETVFATALAR DAQVRALSDV PLTAVLNRPD GVEYSRHFSD GAKAGGHVFA
LPIGGTAPRG RWTLSLFTDP DAPSVTTANF LVEDFLPERI DFDITLPDGA LRPGDTVLAG
LEARYLFGAP AGGLPVEGEV ALRATRSMPD WPGFVFGRHD EDSYVEVNYL GGEVETNAAG
FASLPVELPR MAEGTKPVEA ILALRVSEGS GRPVERKITR PLASEGLLLG LKPQFEDVVK
QGTEAGFDLI ALGPDGAATE AQVQWTLNRV HTRYQWYQLD GNWNWEPFTR REKLATGAAV
MTDGRLSLSL PVDWGEHELV VEQTGGGKAA VSQTFYAGWY APADTSKTPD TLELSLDKPA
YLPGEVAKLR VVPRFAGTAL VQVMADRLIA MQTVELTQGE NVVDVPVTDD WGAGAYVTAT
LLRPADVDAD RNPHRALGLA YATVDPGPAK LTAEFVAPNE AAPRAPLEVA LRVNGIQPGE
TAYATIAAVD VGILNLTGFQ SPDLHDHYFG QRRLGVEMRD IYGRLIDGLN GAMGQVRSGG
DAGASAGLQA PPPTEELVAY FSGPVTVGAD GLARAQFDLP SFNGTVRVMA VAWSPTGVGQ
AQADILVRDP VVVTASLPRF LAPGDESRLL LEIVHATGPA GRVGLGVVGN GLLLDTTAVP
SGLTLDPLGK AVLSIPVTAT HVGNQTIDVA LTTPDGKQLT KTLKLPVQVN DPEVTRTSRF
ALAAGQSFTF DANVFAGLMP GTGQATVSVG PLARFDTAGL LQALDRYPYG CTEQITSRAL
PLLYLNSVAE AMQLASRDQT EERINQAIAE VLTNQSASGA FGLWRPSNGD MWLDAYVTDF
LGRARSQGFD VPQNAYRAAL DNLRNQVNYA PDFDIGGEDI AYALMVLARE GAAAIGDLRY
YADVKADGLA TPLAQAQLGA ALAAYGDQTR ADAMFARAAA EVGGRQSWTE GPLWRVDYGT
DRRDAAAVLA LAAEAGSNVI DAEAFAQVIN GGNARRSTQE NAWTLLAAHA LIDRAPTSGI
TMNGNQVDGP MVRVLEDQAM SPLAIANGSD RQTTLTLTTY GVPSEPVPAG GNGYRLTRSY
YSLDGELVDP SQVTQGTRLV VVLHVTPFER SEARLMVNDP LPAGFEIDNP NLLRAGDVRS
LDWLEAVSDI ENAEFRQDRF LAAVDRFGAE PFRLAYIVRA TTPGSFRHPA ASVEDMYRPD
YRAWTDAGRV TVSQ
//
