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Database: UniProt
Entry: A0A044RBX9_ONCVO
LinkDB: A0A044RBX9_ONCVO
Original site: A0A044RBX9_ONCVO 
ID   A0A044RBX9_ONCVO        Unreviewed;       613 AA.
AC   A0A044RBX9;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   28-MAR-2018, entry version 20.
DE   RecName: Full=Mannosyltransferase {ECO:0000256|RuleBase:RU363075};
DE            EC=2.4.1.- {ECO:0000256|RuleBase:RU363075};
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida;
OC   Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282 {ECO:0000313|EnsemblMetazoa:OVOC11628, ECO:0000313|Proteomes:UP000024404};
RN   [1] {ECO:0000313|EnsemblMetazoa:OVOC11628, ECO:0000313|Proteomes:UP000024404}
RP   NUCLEOTIDE SEQUENCE.
RA   Cotton J., Tsai J., Stanley E., Tracey A., Holroyd N., Lustigman S.,
RA   Berriman M.;
RT   "Genome sequencing of Onchocerca volvulus.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:OVOC11628}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU363075}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU363075}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 22 family.
CC       {ECO:0000256|RuleBase:RU363075}.
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DR   EMBL; CMVM020000001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EnsemblMetazoa; OVOC11628; OVOC11628; WBGene00248437.
DR   OMA; TWEWTER; -.
DR   OrthoDB; EOG091G08V8; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016757; F:transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:InterPro.
DR   CDD; cd11566; eIF1_SUI1; 1.
DR   InterPro; IPR005599; GPI_mannosylTrfase.
DR   InterPro; IPR001950; SUI1.
DR   InterPro; IPR036877; SUI1_dom_sf.
DR   InterPro; IPR005874; SUI1_euk.
DR   PANTHER; PTHR22760; PTHR22760; 1.
DR   Pfam; PF03901; Glyco_transf_22; 1.
DR   Pfam; PF01253; SUI1; 1.
DR   SUPFAM; SSF55159; SSF55159; 2.
DR   PROSITE; PS50296; SUI1; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000024404};
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU363075};
KW   Glycosyltransferase {ECO:0000256|RuleBase:RU363075};
KW   Membrane {ECO:0000256|RuleBase:RU363075};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024404};
KW   Transferase {ECO:0000256|RuleBase:RU363075};
KW   Transmembrane {ECO:0000256|RuleBase:RU363075};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363075}.
FT   TRANSMEM     79     99       Helical. {ECO:0000256|RuleBase:RU363075}.
FT   TRANSMEM    136    157       Helical. {ECO:0000256|RuleBase:RU363075}.
FT   TRANSMEM    191    210       Helical. {ECO:0000256|RuleBase:RU363075}.
FT   TRANSMEM    238    264       Helical. {ECO:0000256|RuleBase:RU363075}.
FT   TRANSMEM    276    295       Helical. {ECO:0000256|RuleBase:RU363075}.
FT   TRANSMEM    331    355       Helical. {ECO:0000256|RuleBase:RU363075}.
FT   TRANSMEM    362    379       Helical. {ECO:0000256|RuleBase:RU363075}.
FT   TRANSMEM    385    401       Helical. {ECO:0000256|RuleBase:RU363075}.
FT   TRANSMEM    413    431       Helical. {ECO:0000256|RuleBase:RU363075}.
FT   DOMAIN       31     65       SUI1. {ECO:0000259|PROSITE:PS50296}.
FT   DOMAIN      566    601       SUI1. {ECO:0000259|PROSITE:PS50296}.
SQ   SEQUENCE   613 AA;  71428 MW;  76EC8535B419C2D1 CRC64;
     MTAASSIQNL NKPKDAFEQL EDEEGTRQGF CHIRIQQRTG RKTITTVQGI APEYDLKKIV
     RYLKKIVYPE TNVMPSKNFT LLCALIALRI LNVFLVRTYF VPDELFQSVE VAHWAVYGTG
     YLSWEWMASL RSVLHPFIIA ILYFLGHLCA IDSNLFIIQT PRALHAVLFA LSDYCYYKFA
     RRILSPNGAK YALLSYLSCW FVWYCAPRTL SNTLETILTL FALQWYPLSK ADLKQSYFWP
     YMSIGLLTIL IRPTAILIWI PFGLWHLWRS DSIMKLLLHH TFLSCFPVLF LVIVLDSISY
     GKLTFTAWNF IRFNVLEGGS DHFGSHPWHW FISQGLLAVL TIHLVPIFWG MVVAVRNRSV
     PFVFFCVPVL YITIHSLIAH KEHRFLLPII PLLCLFAGIF FHDRLQHQSH IFWIRLLLVV
     NISLAGYFGL FHQSGPFSAT YWITEDAKLR FSKGQHFELI QLMPCFSLPQ YSYFHDFNVT
     VTALDCSPNF THHPDYIDQA DHFHDDPKRW IDANLDLVKK AHYLVFYEKT YRTIQNSIIP
     LGFKICAHFF HAHFLSSIRQ DHYIVEYNCN GTTVDHPEYG EVIQLTGDQR QHIKDFLCRV
     GIVKEENCKI HGF
//
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