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Database: UniProt
Entry: A0A044SLK2_ONCVO
LinkDB: A0A044SLK2_ONCVO
Original site: A0A044SLK2_ONCVO 
ID   A0A044SLK2_ONCVO        Unreviewed;       793 AA.
AC   A0A044SLK2;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   16-JAN-2019, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:OVOC2808};
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282 {ECO:0000313|EnsemblMetazoa:OVOC2808, ECO:0000313|Proteomes:UP000024404};
RN   [1] {ECO:0000313|EnsemblMetazoa:OVOC2808, ECO:0000313|Proteomes:UP000024404}
RP   NUCLEOTIDE SEQUENCE.
RA   Cotton J., Tsai J., Stanley E., Tracey A., Holroyd N., Lustigman S.,
RA   Berriman M.;
RT   "Genome sequencing of Onchocerca volvulus.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:OVOC2808}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2014) to UniProtKB.
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DR   EMBL; CMVM020000076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EnsemblMetazoa; OVOC2808; OVOC2808; WBGene00239617.
DR   OMA; QSAPDFY; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0040026; P:positive regulation of vulval development; IEA:EnsemblMetazoa.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000024404};
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-
KW   ProRule:PRU00168, ECO:0000256|SAAS:SAAS01081641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024404}.
FT   DOMAIN       61    187       N-terminal Ras-GEF. {ECO:0000259|PROSITE:
FT                                PS50212}.
FT   DOMAIN      232    511       Ras-GEF. {ECO:0000259|PROSITE:PS50009}.
FT   DOMAIN      666    760       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
SQ   SEQUENCE   793 AA;  90223 MW;  9316876289166EFD CRC64;
     MTAAKYFGEE KLEDAIYAIY LRKVRYVSPS NIELSDDRTL DIKKHGISVD NTDHLQWETI
     RERIIRAGTL QKLVECLISD DMLMDSRHFN VFFATYRCFA TCSNVLELLL QRYVSLEMNS
     LVIGKAKAAT LQCSLRSVIM CWLEMYPEDF NEPSSDFSTL MRLIEFGRIH KISDMRTKAR
     QLRETYKRQV MDGRYLAQIP SMEQYVFNTG YDAPDFDTCV QRANMFDIGK ENCVQIAEQL
     TFWDAELFKE LLPQQCQGCV WNKRNKLGPE TVYTVRATID QFNAVVQKVM TSIVLPDCRS
     DFRAKIIAKW IDVARELRAL KNFSSLKAVI STLQSEPVHR LKSTWAQVPN ASLAQFRELA
     SIFDADDDGK ERRARQILEE EGTAKKSPLR RPQLIQNCRR TKSDVNLAES QGTVPYLGTF
     LTDLSMIDQA NPDFTEGKMT ICNLVFFFSE GLINFEKRRK EFEIIAKIRL FQSACRAYKI
     PMDMAFCSWF CFLPALDENQ CFVRSLEVEL PTNQADSSKL FRTSQMSKIN TLSRLISSMN
     VDENPNVSGQ ISNDSGIVTE DLWCDGATKP FAEKTLMTAC SPFGIVSSRS FTAPLTPSST
     VFWKGGSEFS PNTAFSNRRS TSGCWERKHQ PNDVSVGTSL NFYGNMTPET SSGSCISANS
     LQQTVPFHLA RIALDDSMKN DTGTANYKCV KIENCDRMAE LIERTLEKHL ISGDHSEYCL
     VQLLPDGYEF CLPEKCNPYY AVAPDPTSTM LNFVLRRKSD AERMAMSGSI APSAKKLNKI
     KRCNLLRWSS GYL
//
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