ID A0A045GUJ2_MYCTX Unreviewed; 157 AA.
AC A0A045GUJ2;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=thioredoxin-dependent peroxiredoxin {ECO:0000256|ARBA:ARBA00013017};
DE EC=1.11.1.24 {ECO:0000256|ARBA:ARBA00013017};
DE AltName: Full=Thioredoxin peroxidase {ECO:0000256|ARBA:ARBA00032824};
GN Name=bcp {ECO:0000313|EMBL:CKS14120.1};
GN Synonyms=bcp_3 {ECO:0000313|EMBL:OMH60464.1};
GN ORFNames=A4S10_02644 {ECO:0000313|EMBL:OMH60464.1}, ERS007657_01614
GN {ECO:0000313|EMBL:CFR77853.1}, ERS007665_03049
GN {ECO:0000313|EMBL:CNV46580.1}, ERS007679_02178
GN {ECO:0000313|EMBL:COV62171.1}, ERS007681_03106
GN {ECO:0000313|EMBL:CFE42108.1}, ERS007688_02008
GN {ECO:0000313|EMBL:CFE51955.1}, ERS007703_00505
GN {ECO:0000313|EMBL:COV09413.1}, ERS007720_02574
GN {ECO:0000313|EMBL:COW40492.1}, ERS007741_02784
GN {ECO:0000313|EMBL:COW60357.1}, ERS027646_01335
GN {ECO:0000313|EMBL:CKS14120.1}, ERS027659_03011
GN {ECO:0000313|EMBL:CKS37139.1}, ERS027661_02588
GN {ECO:0000313|EMBL:CKS10075.1}, ERS053720_02496
GN {ECO:0000313|EMBL:CFH85114.1}, GJE03_13285
GN {ECO:0000313|EMBL:QGK79695.1}, SAMEA2683035_01940
GN {ECO:0000313|EMBL:SGH75283.1};
OS Mycobacterium tuberculosis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773 {ECO:0000313|EMBL:CKS14120.1, ECO:0000313|Proteomes:UP000048948};
RN [1] {ECO:0000313|EMBL:COV09413.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K00500041 {ECO:0000313|EMBL:COV09413.1};
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000038802, ECO:0000313|Proteomes:UP000044938}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGH75283.1,
RC ECO:0000313|Proteomes:UP000182946}, Bir 172
RC {ECO:0000313|EMBL:CKS14120.1, ECO:0000313|Proteomes:UP000048948}, Bir
RC 185 {ECO:0000313|EMBL:CKS37139.1, ECO:0000313|Proteomes:UP000050164},
RC Bir 187 {ECO:0000313|EMBL:CKS10075.1,
RC ECO:0000313|Proteomes:UP000049023}, C09601061
RC {ECO:0000313|EMBL:CFR77853.1, ECO:0000313|Proteomes:UP000046680},
RC D00700688 {ECO:0000313|EMBL:CNV46580.1,
RC ECO:0000313|Proteomes:UP000045274}, G09801536
RC {ECO:0000313|EMBL:COV62171.1, ECO:0000313|Proteomes:UP000045842},
RC G09901357 {ECO:0000313|EMBL:CFE42108.1,
RC ECO:0000313|Proteomes:UP000048289}, H09601792
RC {ECO:0000313|EMBL:CFE51955.1, ECO:0000313|Proteomes:UP000046947},
RC K00500041 {ECO:0000313|Proteomes:UP000038802}, M09401471
RC {ECO:0000313|EMBL:COW40492.1, ECO:0000313|Proteomes:UP000044938}, and
RC P00601463 {ECO:0000313|EMBL:COW60357.1,
RC ECO:0000313|Proteomes:UP000048600};
RG Pathogen Informatics;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CFH85114.1, ECO:0000313|Proteomes:UP000046674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0351H {ECO:0000313|EMBL:CFH85114.1,
RC ECO:0000313|Proteomes:UP000046674};
RG Pathogen Informatics;
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:OMH60464.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH60464.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M., Bigi F., Soria M.A.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:OMH60464.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH60464.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M.M., Lopez B., Blanco F.C., Sasiain M.C., De La Barrera S.,
RA Ritacco V., Bigi F., Soria M.A.;
RT "Protein polymorphisms may explain contrasting epidemiological fitness of
RT two variants of a multidrug-resistant Mycobacterium tuberculosis strain.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:QGK79695.1, ECO:0000313|Proteomes:UP000388593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AUSMDU00018547 {ECO:0000313|EMBL:QGK79695.1,
RC ECO:0000313|Proteomes:UP000388593};
RA Baines S.L., Goncalves da Silva A., Carter G.P., Jennison A.V.,
RA Rathnayake I.U., Graham R.M.A., Sintchenko V., Wang Q., Rockett R.J.,
RA Timms V.J., Martinez E., Ballard S., Tomita T., Isles N., Horan K.A.,
RA Pitchers W., Stinear T.P., Williamson D.A., Howden B.P., Seemann T.;
RT "Complete microbial genomes for public health in Australia and Southwest
RT Pacific.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of
CC hydrogen peroxide and organic hydroperoxides to water and alcohols,
CC respectively. Plays a role in cell protection against oxidative stress
CC by detoxifying peroxides and as sensor of hydrogen peroxide-mediated
CC signaling events. {ECO:0000256|ARBA:ARBA00003330}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-
CC disulfide + an alcohol + H2O; Xref=Rhea:RHEA:62620, Rhea:RHEA-
CC COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924,
CC ChEBI:CHEBI:50058; EC=1.11.1.24;
CC Evidence={ECO:0000256|ARBA:ARBA00000280};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.
CC {ECO:0000256|ARBA:ARBA00038489}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CFOE01000491; CFE42108.1; -; Genomic_DNA.
DR EMBL; CFOH01000298; CFE51955.1; -; Genomic_DNA.
DR EMBL; CFSW01000015; CFH85114.1; -; Genomic_DNA.
DR EMBL; CGCX01000520; CFR77853.1; -; Genomic_DNA.
DR EMBL; CNFU01000565; CKS10075.1; -; Genomic_DNA.
DR EMBL; CNGE01000188; CKS14120.1; -; Genomic_DNA.
DR EMBL; CNFT01000804; CKS37139.1; -; Genomic_DNA.
DR EMBL; CQPW01000760; CNV46580.1; -; Genomic_DNA.
DR EMBL; CSAE01000030; COV09413.1; -; Genomic_DNA.
DR EMBL; CSAD01000281; COV62171.1; -; Genomic_DNA.
DR EMBL; CSAJ01000339; COW40492.1; -; Genomic_DNA.
DR EMBL; CHKL01000353; COW60357.1; -; Genomic_DNA.
DR EMBL; LWDQ01000001; OMH60464.1; -; Genomic_DNA.
DR EMBL; CP045962; QGK79695.1; -; Genomic_DNA.
DR EMBL; FPTZ01000011; SGH75283.1; -; Genomic_DNA.
DR RefSeq; WP_003412944.1; NZ_WUCS01000012.1.
DR STRING; 115862.BBG46_13230; -.
DR PATRIC; fig|1773.211.peg.3933; -.
DR OMA; PKKFMGK; -.
DR Proteomes; UP000038802; Unassembled WGS sequence.
DR Proteomes; UP000044938; Unassembled WGS sequence.
DR Proteomes; UP000045274; Unassembled WGS sequence.
DR Proteomes; UP000045842; Unassembled WGS sequence.
DR Proteomes; UP000046674; Unassembled WGS sequence.
DR Proteomes; UP000046680; Unassembled WGS sequence.
DR Proteomes; UP000046947; Unassembled WGS sequence.
DR Proteomes; UP000048289; Unassembled WGS sequence.
DR Proteomes; UP000048600; Unassembled WGS sequence.
DR Proteomes; UP000048948; Unassembled WGS sequence.
DR Proteomes; UP000049023; Unassembled WGS sequence.
DR Proteomes; UP000050164; Unassembled WGS sequence.
DR Proteomes; UP000182946; Unassembled WGS sequence.
DR Proteomes; UP000189452; Chromosome.
DR Proteomes; UP000388593; Chromosome.
DR GO; GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.
DR CDD; cd03017; PRX_BCP; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR000866; AhpC/TSA.
DR InterPro; IPR024706; Peroxiredoxin_AhpC-typ.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR42801:SF24; PEROXIREDOXIN BCP; 1.
DR PANTHER; PTHR42801; THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE; 1.
DR Pfam; PF00578; AhpC-TSA; 1.
DR PIRSF; PIRSF000239; AHPC; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CKS14120.1}; Peroxidase {ECO:0000313|EMBL:CKS14120.1}.
FT DOMAIN 7..157
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT ACT_SITE 49
FT /note="Cysteine sulfenic acid (-SOH) intermediate; for
FT peroxidase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
SQ SEQUENCE 157 AA; 17077 MW; 1A23D6E311FD698D CRC64;
MTKTTRLTPG DKAPAFTLPD ADGNNVSLAD YRGRRVIVYF YPAASTPGCT KQACDFRDNL
GDFTTAGLNV VGISPDKPEK LATFRDAQGL TFPLLSDPDR EVLTAWGAYG EKQMYGKTVQ
GVIRSTFVVD EDGKIVVAQY NVKATGHVAK LRRDLSV
//
