UniProt: A0A045HFC2

Database: UniProt
Entry: A0A045HFC2_MYCTX

LinkDB:  A0A045HFC2_MYCTX 
Original site:  A0A045HFC2_MYCTX

All links

Ontology (2)   
   GO (2)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (11)   
   EMBL (11)   
Protein domain (12)   
   InterPro (7)   
   Pfam (3)   
   PROSITE (1)   
   SMART (1)   
All databases (26)   

Download RDF

ID   A0A045HFC2_MYCTX        Unreviewed;       705 AA.
AC   A0A045HFC2;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=Fatty-acid-CoA ligase {ECO:0000313|EMBL:SGH91784.1};
DE   SubName: Full=p-hydroxybenzoic acid--AMP ligase FadD22 {ECO:0000313|EMBL:OMH60891.1};
DE            EC=6.2.1.- {ECO:0000313|EMBL:OMH60891.1, ECO:0000313|EMBL:SGH91784.1};
GN   Name=fadD22 {ECO:0000313|EMBL:SGH91784.1};
GN   ORFNames=A4S10_03076 {ECO:0000313|EMBL:OMH60891.1}, ERS007657_00007
GN   {ECO:0000313|EMBL:CFR64212.1}, ERS007665_00214
GN   {ECO:0000313|EMBL:CNU01014.1}, ERS007679_02881
GN   {ECO:0000313|EMBL:COV99932.1}, ERS007720_00986
GN   {ECO:0000313|EMBL:COV82036.1}, ERS007741_01044
GN   {ECO:0000313|EMBL:COV95534.1}, ERS027646_01281
GN   {ECO:0000313|EMBL:CKS11199.1}, ERS027659_00590
GN   {ECO:0000313|EMBL:CKR03524.1}, ERS027661_00507
GN   {ECO:0000313|EMBL:CKR04917.1}, ERS053720_02725
GN   {ECO:0000313|EMBL:CFH87322.1}, SAMEA2683035_02317
GN   {ECO:0000313|EMBL:SGH91784.1};
OS   Mycobacterium tuberculosis.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1773 {ECO:0000313|EMBL:SGH91784.1, ECO:0000313|Proteomes:UP000182946};
RN   [1] {ECO:0000313|EMBL:CFH87322.1, ECO:0000313|Proteomes:UP000046674}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=0351H {ECO:0000313|EMBL:CFH87322.1,
RC   ECO:0000313|Proteomes:UP000046674};
RG   Pathogen Informatics;
RA   Murphy D.;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:OMH60891.1, ECO:0000313|Proteomes:UP000189452}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6548 {ECO:0000313|EMBL:OMH60891.1,
RC   ECO:0000313|Proteomes:UP000189452};
RA   Bigi M., Bigi F., Soria M.A.;
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:SGH91784.1, ECO:0000313|Proteomes:UP000182946}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGH91784.1,
RC   ECO:0000313|Proteomes:UP000182946}, Bir 172
RC   {ECO:0000313|EMBL:CKS11199.1, ECO:0000313|Proteomes:UP000048948}, Bir
RC   185 {ECO:0000313|EMBL:CKR03524.1, ECO:0000313|Proteomes:UP000050164},
RC   Bir 187 {ECO:0000313|EMBL:CKR04917.1,
RC   ECO:0000313|Proteomes:UP000049023}, C09601061
RC   {ECO:0000313|EMBL:CFR64212.1, ECO:0000313|Proteomes:UP000046680},
RC   D00700688 {ECO:0000313|EMBL:CNU01014.1,
RC   ECO:0000313|Proteomes:UP000045274}, G09801536
RC   {ECO:0000313|EMBL:COV99932.1, ECO:0000313|Proteomes:UP000045842},
RC   M09401471 {ECO:0000313|EMBL:COV82036.1,
RC   ECO:0000313|Proteomes:UP000044938}, and P00601463
RC   {ECO:0000313|EMBL:COV95534.1, ECO:0000313|Proteomes:UP000048600};
RG   Pathogen Informatics;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:OMH60891.1, ECO:0000313|Proteomes:UP000189452}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6548 {ECO:0000313|EMBL:OMH60891.1,
RC   ECO:0000313|Proteomes:UP000189452};
RA   Bigi M.M., Lopez B., Blanco F.C., Sasiain M.C., De La Barrera S.,
RA   Ritacco V., Bigi F., Soria M.A.;
RT   "Protein polymorphisms may explain contrasting epidemiological fitness of
RT   two variants of a multidrug-resistant Mycobacterium tuberculosis strain.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CFSW01000017; CFH87322.1; -; Genomic_DNA.
DR   EMBL; CGCX01000002; CFR64212.1; -; Genomic_DNA.
DR   EMBL; CNFT01000082; CKR03524.1; -; Genomic_DNA.
DR   EMBL; CNFU01000061; CKR04917.1; -; Genomic_DNA.
DR   EMBL; CNGE01000178; CKS11199.1; -; Genomic_DNA.
DR   EMBL; CQPW01000021; CNU01014.1; -; Genomic_DNA.
DR   EMBL; CSAJ01000086; COV82036.1; -; Genomic_DNA.
DR   EMBL; CHKL01000079; COV95534.1; -; Genomic_DNA.
DR   EMBL; CSAD01000444; COV99932.1; -; Genomic_DNA.
DR   EMBL; LWDQ01000001; OMH60891.1; -; Genomic_DNA.
DR   EMBL; FPTZ01000015; SGH91784.1; -; Genomic_DNA.
DR   RefSeq; WP_003414884.1; NZ_WUCS01000004.1.
DR   PATRIC; fig|1773.206.peg.1465; -.
DR   OMA; GWTKSGD; -.
DR   Proteomes; UP000044938; Unassembled WGS sequence.
DR   Proteomes; UP000045274; Unassembled WGS sequence.
DR   Proteomes; UP000045842; Unassembled WGS sequence.
DR   Proteomes; UP000046674; Unassembled WGS sequence.
DR   Proteomes; UP000046680; Unassembled WGS sequence.
DR   Proteomes; UP000048600; Unassembled WGS sequence.
DR   Proteomes; UP000048948; Unassembled WGS sequence.
DR   Proteomes; UP000049023; Unassembled WGS sequence.
DR   Proteomes; UP000050164; Unassembled WGS sequence.
DR   Proteomes; UP000182946; Unassembled WGS sequence.
DR   Proteomes; UP000189452; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   CDD; cd05919; BCL_like; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   PANTHER; PTHR43352; ACETYL-COA SYNTHETASE; 1.
DR   PANTHER; PTHR43352:SF1; P-HYDROXYBENZOIC ACID--AMP LIGASE FADD22; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   PROSITE; PS50075; CARRIER; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:SGH91784.1};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          541..619
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   705 AA;  75198 MW;  600F2D0EABFDF1DC CRC64;
     MRNGNLAGLL AEQASEAGWY DRPAFYAADV VTHGQIHDGA ARLGEVLRNR GLSSGDRVLL
     CLPDSPDLVQ LLLACLARGV MAFLANPELH RDDHALAARN TEPALVVTSD ALRDRFQPSR
     VAEAAELMSE AARVAPGGYE PMGGDALAYA TYTSGTTGPP KAAIHRHADP LTFVDAMCRK
     ALRLTPEDTG LCSARMYFAY GLGNSVWFPL ATGGSAVINS APVTPEAAAI LSARFGPSVL
     YGVPNFFARV IDSCSPDSFR SLRCVVSAGE ALELGLAERL MEFFGGIPIL DGIGSTEVGQ
     TFVSNRVDEW RLGTLGRVLP PYEIRVVAPD GTTAGPGVEG DLWVRGPAIA KGYWNRPDSP
     VANEGWLDTR DRVCIDSDGW VTYRCRADDT EVIGGVNVDP REVERLIIED EAVAEAAVVA
     VRESTGASTL QAFLVATSGA TIDGSVMRDL HRGLLNRLSA FKVPHRFAVV DRLPRTPNGK
     LVRGALRKQS PTKPIWELSL TEPGSGVRAQ RDDLSASNMT IAGGNDGGAT LRERLVALRQ
     ERQRLVVDAV CAEAAKMLGE PDPWSVDQDL AFSELGFDSQ MTVTLCKRLA AVTGLRLPET
     VGWDYGSISG LAQYLEAELA GGHGRLKSAG PVNSGATGLW AIEEQLNKVE ELVAVIADGE
     KQRVADRLRA LLGTIAGSEA GLGKLIQAAS TPDEIFQLID SELGK
//

DBGET integrated database retrieval system