ID A0A045J128_MYCTX Unreviewed; 646 AA.
AC A0A045J128;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Succinate dehydrogenase {ECO:0000313|EMBL:CKQ77474.1, ECO:0000313|EMBL:QGK77578.1};
DE SubName: Full=Succinate dehydrogenase flavoprotein subunit {ECO:0000313|EMBL:OMH58121.1};
GN Name=sdhA_1 {ECO:0000313|EMBL:CKQ77474.1};
GN ORFNames=A4S10_00269 {ECO:0000313|EMBL:OMH58121.1}, ERS007720_01388
GN {ECO:0000313|EMBL:COV99875.1}, ERS027659_00707
GN {ECO:0000313|EMBL:CKR09653.1}, ERS027661_00037
GN {ECO:0000313|EMBL:CKQ77474.1}, ERS053720_00551
GN {ECO:0000313|EMBL:CFH71112.1}, GJE03_01335
GN {ECO:0000313|EMBL:QGK77578.1}, SAMEA2683035_01826
GN {ECO:0000313|EMBL:SGH70511.1};
OS Mycobacterium tuberculosis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773 {ECO:0000313|EMBL:CKQ77474.1, ECO:0000313|Proteomes:UP000049023};
RN [1] {ECO:0000313|EMBL:CFH71112.1, ECO:0000313|Proteomes:UP000046674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0351H {ECO:0000313|EMBL:CFH71112.1,
RC ECO:0000313|Proteomes:UP000046674};
RG Pathogen Informatics;
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000044938, ECO:0000313|Proteomes:UP000049023}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGH70511.1,
RC ECO:0000313|Proteomes:UP000182946}, Bir 185
RC {ECO:0000313|EMBL:CKR09653.1, ECO:0000313|Proteomes:UP000050164}, Bir
RC 187 {ECO:0000313|EMBL:CKQ77474.1, ECO:0000313|Proteomes:UP000049023},
RC and M09401471 {ECO:0000313|EMBL:COV99875.1,
RC ECO:0000313|Proteomes:UP000044938};
RG Pathogen Informatics;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:OMH58121.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH58121.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M., Bigi F., Soria M.A.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:OMH58121.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH58121.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M.M., Lopez B., Blanco F.C., Sasiain M.C., De La Barrera S.,
RA Ritacco V., Bigi F., Soria M.A.;
RT "Protein polymorphisms may explain contrasting epidemiological fitness of
RT two variants of a multidrug-resistant Mycobacterium tuberculosis strain.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:QGK77578.1, ECO:0000313|Proteomes:UP000388593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AUSMDU00018547 {ECO:0000313|EMBL:QGK77578.1,
RC ECO:0000313|Proteomes:UP000388593};
RA Baines S.L., Goncalves da Silva A., Carter G.P., Jennison A.V.,
RA Rathnayake I.U., Graham R.M.A., Sintchenko V., Wang Q., Rockett R.J.,
RA Timms V.J., Martinez E., Ballard S., Tomita T., Isles N., Horan K.A.,
RA Pitchers W., Stinear T.P., Williamson D.A., Howden B.P., Seemann T.;
RT "Complete microbial genomes for public health in Australia and Southwest
RT Pacific.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CFSW01000003; CFH71112.1; -; Genomic_DNA.
DR EMBL; CNFU01000003; CKQ77474.1; -; Genomic_DNA.
DR EMBL; CNFT01000103; CKR09653.1; -; Genomic_DNA.
DR EMBL; CSAJ01000136; COV99875.1; -; Genomic_DNA.
DR EMBL; LWDQ01000001; OMH58121.1; -; Genomic_DNA.
DR EMBL; CP045962; QGK77578.1; -; Genomic_DNA.
DR EMBL; FPTZ01000010; SGH70511.1; -; Genomic_DNA.
DR RefSeq; WP_003401322.1; NZ_WMCK01000004.1.
DR GeneID; 45424221; -.
DR PATRIC; fig|1773.206.peg.3318; -.
DR OMA; FMDTIEG; -.
DR Proteomes; UP000044938; Unassembled WGS sequence.
DR Proteomes; UP000046674; Unassembled WGS sequence.
DR Proteomes; UP000049023; Unassembled WGS sequence.
DR Proteomes; UP000050164; Unassembled WGS sequence.
DR Proteomes; UP000182946; Unassembled WGS sequence.
DR Proteomes; UP000189452; Chromosome.
DR Proteomes; UP000388593; Chromosome.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR GO; GO:0008152; P:metabolic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.20.58.100; Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain; 1.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR InterPro; IPR030664; SdhA/FrdA/AprA.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR PANTHER; PTHR11632; SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT; 1.
DR PANTHER; PTHR11632:SF89; SUCCINATE DEHYDROGENASE [IRON-SULFUR SUBUNIT] (SUCCINIC DEHYDROGENASE)-RELATED; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF02910; Succ_DH_flav_C; 1.
DR PIRSF; PIRSF000171; SDHA_APRA_LASPO; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00411; PNDRDTASEI.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF46977; Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 10..429
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
FT DOMAIN 488..587
FT /note="Fumarate reductase/succinate dehydrogenase
FT flavoprotein-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02910"
FT ACT_SITE 322
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000171-1"
SQ SEQUENCE 646 AA; 70681 MW; 93E22EC39F6DD261 CRC64;
MVEVERHSYD VVVIGAGGAG LRAVIEARER GLKVAVVCKS LFGKAHTVMA EGGCAAAMGN
ANPKDNWKTH FGDTMRGGKF LNNWRMAELH AKEAPDRVWE LETYGALFDR TDDGRISQRN
FGGHTYPRLA HVGDRTGLEL IRTLQQKVVS LQQEDHAELG DYEARIKVFA ECTITELLKD
QGAIAGAFGY WRESGRFIVF EAPAVVLATG GIGKSFKVTS NSWEYTGDGH ALALRAGATL
INMEFVQFHP TGMVWPPSVK GILVTEGVRG DGGVLKNSEN SRFMFDYIPP VFKGQYAETE
EEADQWLKDN DSARRTPDLL PRDEVARAIN SEVKAGRGTP HGGVYLDIAS RLTPAEIKRR
LPSMYHQFKE LAEVDITTQA MEVGPTCHYV MGGVEVDADT GAATVPGLFA AGECAGGMHG
SNRLGGNSLS DLLVFGRRAG LGAADYVRAL SSRPAVSAEA IDAAAQQALS PFEGPKDGSA
PENPYALHMD LQYVMNDLVG IIRNADEISR ALTLLAELWS RYHNVLVEGH RQYNPGWNLS
IDLRNMLLVS ECVARAALQR TESRGGHTRD DHPGMDPNWR RILLVCRATE TMGTGGSGSG
DSNCHINVTQ QLQTPMRPDL LELFEISELE KYYTDEELAE HPGRRG
//
