ID A0A058Z3D2_FONAL Unreviewed; 1153 AA.
AC A0A058Z3D2;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Exportin-T {ECO:0000256|ARBA:ARBA00018928, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=Exportin(tRNA) {ECO:0000256|ARBA:ARBA00029784, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=tRNA exportin {ECO:0000256|ARBA:ARBA00032199, ECO:0000256|RuleBase:RU366037};
GN ORFNames=H696_04194 {ECO:0000313|EMBL:KCV68775.1};
OS Fonticula alba (Slime mold).
OC Eukaryota; Rotosphaerida; Fonticulaceae; Fonticula.
OX NCBI_TaxID=691883 {ECO:0000313|EMBL:KCV68775.1};
RN [1] {ECO:0000313|EMBL:KCV68775.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38817 {ECO:0000313|EMBL:KCV68775.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Brown M., Walker B., Young S.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Fonticula alba ATCC 38817.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex.
CC {ECO:0000256|RuleBase:RU366037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU366037}. Nucleus
CC {ECO:0000256|RuleBase:RU366037}. Note=Shuttles between the nucleus and
CC the cytoplasm. {ECO:0000256|RuleBase:RU366037}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|RuleBase:RU366037}.
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DR EMBL; KB932207; KCV68775.1; -; Genomic_DNA.
DR RefSeq; XP_009496346.1; XM_009498071.1.
DR AlphaFoldDB; A0A058Z3D2; -.
DR STRING; 691883.A0A058Z3D2; -.
DR EnsemblProtists; KCV68775; KCV68775; H696_04194.
DR GeneID; 20528919; -.
DR eggNOG; KOG2021; Eukaryota.
DR OrthoDB; 2546268at2759; -.
DR Proteomes; UP000030693; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952:SF11; EXPORTIN-T; 1.
DR PANTHER; PTHR15952; EXPORTIN-T/LOS1; 1.
DR Pfam; PF19282; Exportin-T; 3.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU366037};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366037};
KW Reference proteome {ECO:0000313|Proteomes:UP000030693};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU366037};
KW Transport {ECO:0000256|RuleBase:RU366037};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555,
KW ECO:0000256|RuleBase:RU366037}.
FT DOMAIN 105..253
FT /note="Exportin-1/Importin-beta-like"
FT /evidence="ECO:0000259|Pfam:PF08389"
FT DOMAIN 318..580
FT /note="Exportin-T C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19282"
FT DOMAIN 632..853
FT /note="Exportin-T C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19282"
FT DOMAIN 942..1149
FT /note="Exportin-T C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19282"
FT REGION 873..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1024..1043
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1153 AA; 125368 MW; 9AC5E6FB182DDD8D CRC64;
MDYAKFDQAV ALCFDSASPA DVKAQALEYV EMIRLAPDGW RFCLQLFLER PAGIRGETFY
ICLQVLQDAV QFRYAAIPTD QRLSLRNSLM QWLSSFATAH ANDPVYFKHK FLTVLVHIFM
HEYLTSWGSF FQDILSLIHQ SPAMVDMYLR ILIILDQELI SRDIQRFPTE AALATNIKDR
MRDTDVPQLV DSWYFILGTY HSSDPGLINL CLSVIGIYVS WIELDLVVTP NFVSAYSSFL
KSEQFRDAAC ECVNGIVLKG MPPLSRLALL DKLHLHNIFE AFIMKSSDIS EPVIKLFNDT
AVSLISSWNE LAGEKAYQAQ VYTVIESLLP VLYKLLGESE DTDLGVIFEF SQAFLVLLRQ
SARSTPLTGE QLAALERLLQ ILVSKLKFPA DFDFSHDDEG RQEVDDFRRT IKIQLDHICS
IQQSIFVSFV ERNVLAVLSN PSAPYQDAEL ALFLLYTYSD CIKTSLRFSR TVPPEEQALF
SLHAMLHSMI TSNIVSYPHS AVQLLFFENA VRYAQFFGVF TEYIEATLVA FLDSRGLRHH
DPYVRRRTTY LLARFVRTLL SQLTPHTNAL LSGIQELLAL PEPTLATSAI FQAVPANAAA
WQQLLQDRDS GPAKAGVPAE PGSGAVAAAG QHFSQFDDQL HLFEVVGLLL GNRSFAPAEL
AGQYTVTVVQ PLLTQMSAIL QEGRYREAPP GRAATEPRHL ALLHMAVTAI SHLVKGFPSA
QQPAAGAGGG HSAASWEPAL RDCLQAALAV LDALDAYQKE LAAAGNAPGT AWLVAVEAPM
RDAVRQLFQR LVGCATCDLM ALVPGALERL LRHASAFALA EFLPVLAQLT FRYREAFLPT
LAGLFPAVVA QILPFARQEL GLIELAAGSP KPGAGGAGGG PGGAGAAGAT TAGAPPGGAS
QPQQPAAAAA GAHAPGFKGG TAGGTASSSV AAAAAVGATV NTEELQRLND IRRAYLAFLN
AIFQERMEHI LVSEVNLPVL PTILASVTLL AARCLEPAIQ RAALGVLSRM AVAWLQPGDG
QTPLPGGPGA PPPEQALPPP PTEPVNISRL RLPDFLPFAL NEVQPLVFSI PLAPTFDVSN
ASSLAVLNDL TLLQQRLIQT LGVSCTSFLT GQYLPSIGLP ADVAADYVNA AMNQDPRQFR
QLFRRFITRH RGG
//
