ID   A0A058Z760_FONAL        Unreviewed;       720 AA.
AC   A0A058Z760;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Endopeptidase S2P {ECO:0000256|ARBA:ARBA00032658};
GN   ORFNames=H696_03793 {ECO:0000313|EMBL:KCV69362.1};
OS   Fonticula alba (Slime mold).
OC   Eukaryota; Rotosphaerida; Fonticulaceae; Fonticula.
OX   NCBI_TaxID=691883 {ECO:0000313|EMBL:KCV69362.1};
RN   [1] {ECO:0000313|EMBL:KCV69362.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 38817 {ECO:0000313|EMBL:KCV69362.1};
RG   The Broad Institute Genomics Platform;
RA   Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA   Lang F.B.F., Roger A.J., Ruiz-Trillo I., Brown M., Walker B., Young S.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA   Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Fonticula alba ATCC 38817.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; KB932206; KCV69362.1; -; Genomic_DNA.
DR   RefSeq; XP_009495927.1; XM_009497652.1.
DR   AlphaFoldDB; A0A058Z760; -.
DR   STRING; 691883.A0A058Z760; -.
DR   EnsemblProtists; KCV69362; KCV69362; H696_03793.
DR   GeneID; 20528518; -.
DR   eggNOG; KOG2921; Eukaryota.
DR   OrthoDB; 5181at2759; -.
DR   Proteomes; UP000030693; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR001193; MBTPS2.
DR   InterPro; IPR008915; Peptidase_M50.
DR   PANTHER; PTHR13325:SF3; MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE; 1.
DR   PANTHER; PTHR13325; PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE; 1.
DR   Pfam; PF02163; Peptidase_M50; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030693};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        113..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        218..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        290..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        584..604
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        696..717
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          226..323
FT                   /note="Peptidase M50"
FT                   /evidence="ECO:0000259|Pfam:PF02163"
FT   REGION          39..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          646..671
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        650..664
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   720 AA;  75946 MW;  63C33FB5943AC880 CRC64;
     MSIPLMTLIL VGILVLAYAG RRRLPVISRM VGRLMRLAGR TPGRGQPSLP GPGHDADLAD
     KSAPNLPVVP QPADAHYTFE RQGLRLGLAI SPADPVAGLL RRRLGGRTAR RALGAWFSIG
     AAVGLVLLLV LPFVLVGLTS LQVAGSVHLV RGTWGGSQPV GGSEPAMSMA AATSRQHGRS
     MHRRAVADLS PPAPPPATAS AVPAPGSGVM MLIPGYNVPL PSMLILALVL LLSVVVHELG
     HALAAVASAM TVQRIHFQLT PFPGGCVIID ETEYERGTFW QRIMVSTAGV WHNLVACLAL
     AIVLPLLVTA VGVAAPAGQS GLAIWRTGAG VAVADVSSTS PLRPYLPLGA RIRRLDGCPV
     LDHESWVSCI DYLNAGAPPM ASAQVGPDSP IPQRFDGYCV SHKTIVEYAT RPEYDCCDRS
     ATRPGANGFC LVDRSPARPG EDPLRPRTSI CLPVYGGISE ATPCGPASAC QPGHMCLSPD
     TAPGTRLVQV KLDYGSADGP TMAESSGVPL PPIFFYGSPL SLWREITVSG YIPRWPRPDA
     PDIFLWQPGP AGQASGSPPP AAPLSAGRPI RALARWGLGL ARRALLWALL LMPVAARYFV
     MYTLSVNVAL AFFNSPACYH FDGLRTAESL IEWVVIARSR AADLPPDAGR LSSEDPERAE
     PGGIAPRRPD ASLAVGPAAR RHARILRQWV VLGNTGLLLA FLLSLVVHTS LTVALVGPQV
//