ID A0A058ZAA6_FONAL Unreviewed; 1479 AA.
AC A0A058ZAA6;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN ORFNames=H696_02156 {ECO:0000313|EMBL:KCV71205.1};
OS Fonticula alba (Slime mold).
OC Eukaryota; Rotosphaerida; Fonticulaceae; Fonticula.
OX NCBI_TaxID=691883 {ECO:0000313|EMBL:KCV71205.1};
RN [1] {ECO:0000313|EMBL:KCV71205.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38817 {ECO:0000313|EMBL:KCV71205.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Brown M., Walker B., Young S.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Fonticula alba ATCC 38817.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|ARBA:ARBA00006460, ECO:0000256|RuleBase:RU004279}.
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DR EMBL; KB932203; KCV71205.1; -; Genomic_DNA.
DR RefSeq; XP_009494328.1; XM_009496053.1.
DR STRING; 691883.A0A058ZAA6; -.
DR EnsemblProtists; KCV71205; KCV71205; H696_02156.
DR GeneID; 20526881; -.
DR eggNOG; KOG0260; Eukaryota.
DR OMA; QAFPIPH; -.
DR OrthoDB; 169836at2759; -.
DR Proteomes; UP000030693; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd02584; RNAP_II_Rpb1_C; 1.
DR CDD; cd02733; RNAP_II_RPB1_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.150.390; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.30.1360.140; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 6.20.50.80; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR007075; RNA_pol_Rpb1_6.
DR InterPro; IPR007073; RNA_pol_Rpb1_7.
DR InterPro; IPR038593; RNA_pol_Rpb1_7_sf.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF37; DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR Pfam; PF04992; RNA_pol_Rpb1_6; 1.
DR Pfam; PF04990; RNA_pol_Rpb1_7; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279};
KW Reference proteome {ECO:0000313|Proteomes:UP000030693};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 224..522
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
SQ SEQUENCE 1479 AA; 165688 MW; 35167FCA65FED3FA CRC64;
MEEPSPAPRK SVKAVQFGLF SPQEISDMSV CCIQHAELYD PATGAPIHGG LFDPRLGPDS
QDHQCATCEM TTECPGHFGH LDLVRPVFHL GFKSKLMRVL RSVCGSCSAL LVKKDDPACK
DILARFTGRH RLQRVSDLAK TRRKCDACEQ YQRLFKYDKM SFGFMYTSKK QVSAGDEGDE
AAGASHGHNQ HDMLTPEIAM RIMKNITDED IDALGFDPVH ARPEWMVIEK LPIPPPQVRP
SVAVEGTKKS NDDLVFALRE IIKRNNMIAN TQQSERDRAK MLINLQYYIK SYMDNHQDPK
FNLKTGRPIK AITQRLKGKE GRIRHNLMGK RVNFSARTVI GPDPSLALDQ VGVPRSIAAN
LTFPERVTPL NHEELTRLVQ AGPQAYPGAR YVTSANGPRR DLARVHDTSA VQLQYGDIVD
RYIRDDDLVL FNRQPSLHKM SMMGHRVKVM PFSTFRLNLS VTTPYNADFD GDEMNLHVPQ
TIEARTELLK LAMVPTQIVS PQANKPVMGI VQDSLLAVNL FSRRDCFLEK HLVMNLLMWF
PHWKGVVPIP AILKPKPLWT GKQLLSMIIP PDISLSTNHS THNEEEDADP ITQHLTPGDT
RVVIDNSVLL SGMVCKKTVG SAQGGLIHVI CIEYSNKPNV AAEFMTNIQY IVNNWLLFHG
FSVGIGDGMI PQSAVDKITS TIRTARVKVI GEINNAIHGD LKEGRGMTIR DTLEGLANAE
LSMVRSEAGK ISLKYLQPFN NFRAMVDAGS KGSSINISQI SACVGQQNVE GKRIPFGFRD
RTLPHFTKDD FSADSRGFVE SSYIEGLNPM EFFFHTMGGR EGLIDTAVKT AETGYIQRRL
IKAMEDIMVR YDGTVRNSLG EVIQFCYGED GLNAQFVEHQ KLDLMSLTNE EFAGRYRINL
LQDPLFKAAN NYVSNTVSQF VMANIKTVQD ALTTEYNQLL EDRATLQEFI FPRLREDKCY
LPVNVLRLIR HSRRMRQHND TLICDLSPVQ IVEEVANLCD RIVVISGDDP ISRTANRNAT
MLFRILIRQY LSVRRVVAEF RFDRSSFQWV IHQIESRFRD SIIHPGEAVG TIAAQSIGEP
ATQMTLNTFH SAGIGAKNIT LGVPRLRELI DVARSIKTPS MSIMLVDEFN HSEKQAHKAL
AAIEHTTLAK VTHKSQVIYD PDQANASVVE ADDDFIQLFF ATENVDPASL SPWVLRLELD
RSAMEAKRCS MDEVAGKIAE HLVPASDFVL MHSHDNYEKL VLRISIRNTS DSMDQNFPGD
KILIQYERKL LSKVVLKGID KIKQVKIDKI QNPSITVDGG LTPSGPAENY LVTTGSNMRD
VLSSEFVEFR NTVTNNIVET CEVLGIEAAR QTLLLELKRV IEFDGNYVNY HHLGLLCDVM
TYRGFLMPIN RHGFNRNSTG ALMRSSYEET VDVLLEAAAH AEIDRMQGVS ENILLGQLSP
VGTGVFDVML DEDKLREAIP LSSVVTGETS YSSSSSSSY
//
