ID A0A058ZBP7_FONAL Unreviewed; 1887 AA.
AC A0A058ZBP7;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Calmodulin {ECO:0008006|Google:ProtNLM};
GN ORFNames=H696_01266 {ECO:0000313|EMBL:KCV71850.1};
OS Fonticula alba (Slime mold).
OC Eukaryota; Rotosphaerida; Fonticulaceae; Fonticula.
OX NCBI_TaxID=691883 {ECO:0000313|EMBL:KCV71850.1};
RN [1] {ECO:0000313|EMBL:KCV71850.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38817 {ECO:0000313|EMBL:KCV71850.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Brown M., Walker B., Young S.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Fonticula alba ATCC 38817.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KB932202; KCV71850.1; -; Genomic_DNA.
DR EMBL; KB932202; KCV71851.1; -; Genomic_DNA.
DR EMBL; KB932202; KCV71852.1; -; Genomic_DNA.
DR RefSeq; XP_009493428.1; XM_009495153.1.
DR RefSeq; XP_009493429.1; XM_009495154.1.
DR RefSeq; XP_009493430.1; XM_009495155.1.
DR STRING; 691883.A0A058ZBP7; -.
DR EnsemblProtists; KCV71850; KCV71850; H696_01266.
DR EnsemblProtists; KCV71851; KCV71851; H696_01266.
DR EnsemblProtists; KCV71852; KCV71852; H696_01266.
DR GeneID; 20525991; -.
DR eggNOG; KOG0266; Eukaryota.
DR eggNOG; KOG0998; Eukaryota.
DR eggNOG; KOG4305; Eukaryota.
DR OrthoDB; 2910300at2759; -.
DR Proteomes; UP000030693; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00030; C2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00174; SH3; 2.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46006:SF9; INTERSECTIN-2 ISOFORM X1; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF12763; EF-hand_4; 1.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00027; EH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50031; EH; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Reference proteome {ECO:0000313|Proteomes:UP000030693};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 148..183
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 149..238
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 1060..1123
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1163..1228
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1294..1483
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1696..1863
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 108..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1613..1650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..946
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..1020
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1060
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1887 AA; 193904 MW; 0A8FA8DBDAC8CDC6 CRC64;
MSSPLTFISQ ADWDKAHGQF SRLSPMGSPI SIGPSMQMLG GTAPADVVAR IGSMCDVDQD
GRLSMVEFIL AAHLVGRLQR GQNVPPGASP AALPPSVLQE VRAFAAGGPR AATPASPPSA
MASPPNSAGS TNSPAGLEND PHWTMSPADR QRYTALFQRQ DAGHSGFVSV DQMMQLLQMK
LAAPVSRQIC DLAARSSPGK LNVDEFCIAM HLATVRLQHG LNLPRTLPPA LVPRSEANFS
TALQGAKTSL GTDKSATPAP VASTGAAPPL LVATREDFER SRRAREEKER LASMPMSQLG
GSGSQQRSVP PPLPAHAPPS HVPPQAVAMG YAGVPAGMYA MQPGMQPGMQ PGMYAMQPGM
QPGMYAMQPG MYAMQPGMHP MQPMQPVHPG MQPVHPGMQP VHPGMQPMQP MQPMQPMQPM
PTVPAQQMPM TMSTQPMQPM PTPQVQMPTP QLQMPTPQLS MPQAATSAGR PSSLALPAGA
TPLPGLAAPT AGTGLAPPPA AAAARGVRSR SNSSAGAFPP NFATGPSSTS EPSGSPSAPA
ADFFAAFDTG RSTSAPAAQS AGPAPAMPSP PATDAIDFSV FDAPSSATRS ASAPAPAPAP
AAAASTPAPG RASSSSKKGA TAAATAPAAA PPHPLSEEMV SLLSDISVLN TELTSLSLSG
RHVGGSRKSS STEQAQRVAR AMALHASCSN RLFTLSSNHA LEALGTGSGF NSAEHESTVA
LAVSQLEIAG KMLASLSASG TTAPAAGAPA TAMPAAQPAL AAPPAASSSA AARAERSATL
AGAVRLAPTG ADSELKAAMG ARAISLPSPS PGSSPAGPLS PAAAGSPASP GGAVPVGAPG
VGLLSMVGAV SGAPAPMQPV RPAAPPASAM PQPVPTSPIR EAYSLDLPDF PAAEPTPVPE
PAAAAPALPA RGGPATGQAA AAAAAPVPGP ALPARTPAPA PVAAPTPAFR PTSVTTNAGP
VPPPRANTGP TPPARADHPA PVSAAAPAPP PRSVSAPAPA PAPAPAAGQA PTPPPRSGKP
SASSSPAAPV QEAFPLPHPE PFSSSVAPPE AAPPPPPAAP PLQLADVLYS FDATRENELT
LIEGQVIHVL ECNGDWWFGN ATMADGSVQS GYFPATYVAL QEATAEAPGA AHNTSNPFSP
TVAAAVPAPA PAPVRQPIDP AALGFTYTRA LFDYVPVAGD ADDQLPLTEG EYFILSEWYD
DGWCRVQSIV PPFDSGVVPC SYVERDVPLP AELIPQLEAY LEDDEDEEFV PPPSVQPSPA
ALAAQGGRVA DLSSFAPRIT TDGAGAVTAT SEERRFKAIQ EFISTEATYV QKLLVLRDEV
ITAFRQFVEP RIMRDIFSNV YELIPCNTHF LADLERRAAV LNPSTGYIDR IGDILIRHLQ
QLQPYTIYCG HQRAAQLAFS SLLERNPRIS HVAQDIFSSS ARLRQLGVLN LTSLLLEPMQ
RVTRYTLLTR AILKYTPEAH PDHADVSLAA SIADNLCSLT NDIARQSTDE MALKKWQQKV
DFGSSPHIDF LGSTRLMGPR ALVHQGVLFK HKSGRQLDAL LTNDFLLLCV PRSSSHSGSS
GHSGSGGHGG AGAAATVGPA SGATSLVVYR TIMPVYSIVA REIGATDGPA GDLAAGASPV
TSPTEALSPS AAAAAGGGGG DSGHGGDDTS FEIHQAGVQT LRVRVKKRQD KQAWMRLINS
TSAAMRQALA ERRLATAQAR WLAADANPNL TGHLTVRIIS GRNIGLSEAE LAAGNRAIAR
AARGRSFFVE VRLGAQVFQT KVVADVAAPR WDEEFTLAVG PGAPSTPPAS DLIASGDIGG
GGGGGTASSA ASIRSVALNA DQASSVLKLT VYDQLEFAPD EFVGSWQLPL DDLIEFFSGT
VNHLRDTALD GVPCGSLTFD ILYRPVY
//
