ID A0A058ZGH6_FONAL Unreviewed; 1280 AA.
AC A0A058ZGH6;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=H696_00182 {ECO:0000313|EMBL:KCV72597.1};
OS Fonticula alba (Slime mold).
OC Eukaryota; Rotosphaerida; Fonticulaceae; Fonticula.
OX NCBI_TaxID=691883 {ECO:0000313|EMBL:KCV72597.1};
RN [1] {ECO:0000313|EMBL:KCV72597.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38817 {ECO:0000313|EMBL:KCV72597.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Brown M., Walker B., Young S.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Fonticula alba ATCC 38817.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR EMBL; KB932201; KCV72597.1; -; Genomic_DNA.
DR RefSeq; XP_009492296.1; XM_009494021.1.
DR AlphaFoldDB; A0A058ZGH6; -.
DR EnsemblProtists; KCV72597; KCV72597; H696_00182.
DR GeneID; 20524907; -.
DR OrthoDB; 211439at2759; -.
DR Proteomes; UP000030693; Unassembled WGS sequence.
DR GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR030559; PolZ_Rev3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR45812; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45812:SF1; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Reference proteome {ECO:0000313|Proteomes:UP000030693};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT DOMAIN 538..1045
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT REGION 493..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 784..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1280 AA; 136269 MW; 0AA3CA7270E9AABA CRC64;
MVVPPGLGSA RDQAATRRLG PLLPFHQRQR HPICPRRYPA AIGRSPAVLA LPRRGLARRH
PVPASSSGPR AAMAPSLAAR ADTLSRSFRW IDPLVSALAA RSASDAGLAA VPGTSPADGP
ATGALLVDTA TGCLLVNVEI IVDMRDSPPG QHIAPDPHIH RLRGFLVTAV GCSLVAPARS
MGDTPISSVL LADDLAAAQC VNLRPAHPHH GLAFRLVRPT PALTADQVEV HLLRGFVAHI
RQLDPDLLCF FGDRVQMLGP GAGFGWACER AWARFGLNLP NELARGPAGP VSQTPLPWSS
PMPGAQRVPF PRLADVRVAG RLLLDVQRLV ARDTDRLALR DYSLSAATLH HLSVRLPALP
PWVLCRLPLA AAGAALLQRS HAVVALLLMT GALSDAAELA RTLGTPLAAM CQHTPRGSQY
RVEAVLTRAM RMVPPRSPPT GLATEPPASE GYLMPTFRLA DVRRLRAPDA GPLVLLPARR
LFSFSPVRAN LPTGADLATP AHPPSSSDED TDEDGRESKG VRTPGTMPPV IDSTRWDDAP
VAVLDFRSLY PSVAIAYNYC YSTCLGRLDD LPKPLSQEPT EIAFGCGTLR TPPPGLLRDL
MDAGALHISP TGVLFAAPAY RRGVLPVLLA SLLQARQRVR RRMRVAPGPE YARLDARQRA
LKMVANLVYG YTGARATGRA PCTDVADAIV GAGRWHLDTL VGQLPGRFPE ARVLYGDTDS
VFVLAGGGPA GGSPAARLRR AMRLGARIEA RVSRELPAPM RLVHEKVYWP CALVARKRYA
GRRFDPGPPS ATDGTSGLPA GSLESRGLET IRRDACPAAG RILHTVLCWL FAMPNDGGFT
GAAIAGVPAC ASAPLRMCPT CDLPLKPVFG RVLPPVVAYW CVCATGPGGA GQLDLSDLRR
LVAEELTRLA GFARSPRQSG YSLHDFSLAQ RLRPGRAGAC RLPGPSSAAR QRLLAADPRA
APALGDRFPV VILRAPGPGS PRDFARLYGT SSAPGRRGDL PLAAGPIASR AMPLDRALRH
ADHFGGVDMT YYIERCLLPP LARILSLVGV GACLSAASGL LFVCCMVLRH FDADIFAWYS
AVPRPVVLAP PVGQARRQGT PGQRPLMHSV LAFIATGQCA GGCGETTTTA RGLCGSCSPG
APGSAGRQLR AASRYAMAQR RADRVAAEFR TAQARCRDCM GLCLSPSQEA RLFMGGLLQE
EMRIPSAGRR PWVDLACEAE AQPGRPVPLM SSPASVPGLI ECLNTECAFL YEAQALLDQL
QDSLDRAREL WRCAAAFEVA
//
