ID A0A059A630_EUCGR Unreviewed; 3002 AA.
AC A0A059A630;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=EUGRSUZ_K02842 {ECO:0000313|EMBL:KCW49283.1};
OS Eucalyptus grandis (Flooded gum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Myrtales; Myrtaceae; Myrtoideae; Eucalypteae; Eucalyptus.
OX NCBI_TaxID=71139 {ECO:0000313|EMBL:KCW49283.1};
RN [1] {ECO:0000313|EMBL:KCW49283.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf extractions {ECO:0000313|EMBL:KCW49283.1};
RA Schmutz J., Hayes R., Myburg A., Tuskan G., Grattapaglia D., Rokhsar D.S.;
RT "The genome of Eucalyptus grandis.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KK198763; KCW49283.1; -; Genomic_DNA.
DR EnsemblPlants; KCW49283; KCW49283; EUGRSUZ_K02842.
DR Gramene; KCW49283; KCW49283; EUGRSUZ_K02842.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1874..2539
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2645..2957
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2970..3002
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT COILED 2394..2428
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2925..2969
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3002 AA; 341537 MW; 275D25D1AEE351C2 CRC64;
MAATVASRDV QEIISKLSSD KAKAREEGIK LLNIWLDGER SFGFCKYLGQ NTLKLSSNEV
PHSETWPFLV KLLIQCVSLE VSSSKKRLPK STYAKSLRIV VQRAHDTKFS GNDLPLISVA
KMLFNHIWDV LSNVPSFQSE YGLILRHLLV VRDYQFHMRK KIYGNMVLLF MEKVKTSLSG
YNQSNVKEEV FRCILLLQCM LENPPGDFPD NIREEIIHGF VRIFSFVREE GKIARKLLEC
FNMFLLKDGP NLGCQVLNIH ETVQQFVLRN WLTSRERGLK DALILYARSQ LNLTKEDAGR
GLVEQLLDVV CKDLDQSTIS TSGVPWSEVV KDDKFGILSG SYCGLVELAA LLFYKSCIST
SKAPSPGKRI KREHAAILLK EALMEGKWSW HAAFCCLLFR YQSCISTDLF TYWFEGICAN
FERIMNDANT EHSYGGFLWT LSLQKLSSLL SLSDSLNEFD SGWQLIWNSL MHGFPLFSNI
TMVADAALML LGNLISRDLV FSYLIPEDIW DLRLFKRTMS ESVLYFISSY FSRKGSQVEP
QDMLHLRKKL LRTVLDGLRW KDSTLFDEKI VLLLPASISA LCSGYDPFKC CHKGTPSSNC
PLSDADAVAG GTKREDQCDN LPHIFDCSVE ALTKIDSCCN REVSLVHLHQ EVHLPPRQLR
ELLLRDLGIH VEGALVLEDP KSKPLSDIFF VCAHLANLIY ALNFIRQRKE EVVVLSNMAK
FLAELLNNAA AVIEEVQNDV HSQGCLGSSV LRDGTSAILV SFRSFVSSPI FKEWRNGNAL
DAVSNRAISQ SIQRLLRALV GLYESRRYER SPQSDVGSSA VDVMLDQYSC QSGGDKSRIV
DMELDAGKDS KNVDISPDGG EMTYGISFSV KCWKLGMISL ISCFFSVEPE MTWEILCGLL
KIECDRKVSE NILHNVFSYP YWSSAVNVLD MVNLLNGMME TQVNLKLDCG NIVAAICTFT
GTLLRLERVR KDGDSLVFFG DEEFDQSLAR LRDMVSAIAE VELLDWSGRL KLVDSICNLV
LISPKVGQML IERLLTMLRD SDYRVRLFLA RRIGVLFQTW EGHEELFEDI CSNFDVPLVF
YLKGKIVPAR DVLAAGPQPR PMMETIILTL CHLALHSEKI ELQAVFMICV ISAIDPCHRV
LANAVLDNLS RMLQYTTRLK YLEELMGPII FCWVTCGVSL AALVEVRHFF VSEVEPRYFV
QYCCDWLLPA LILHEDNKSD LSWLAQISGQ PLAVLVQNHF VPIFAVCMAL HCSKISGWEK
GAMVLQRYIL QIAEISETAR DNLIKKHMVS IVSHLLSLAY DGSDPPLPFF SKDNISCAIR
MVVDGFLDQG DCPSAVGVMD KINIFRPDRV FMFIVEIHHK VASASHHRHR CHRLAEIEVL
VDVLGHRVAS ASTSNYLFNL VGQYIGCHAL QDQCCCIIGT LRKAFENDPS KEITSVLGEQ
LQFLVSKLVT CCIPSDANGE NSPSGSSQVL SLLHQLVLHS APLLHDYIRE LEPFPDIKIF
DELREFHEDL CRVYSPRDHL LKTDGPEFIL KSYTAGAVLL FPARCSQFDY LCSLQALHKK
LLMGESSVNE LHFDARSTQW HDDPEIVDAV WTLVRMCGSE DANSVRALVS DLLSRVGIGD
SHCVVFHRPG YSSHVHICQP IYSGDASEMK FKLQTGMPEE LLLAVLRLLK KYLMDDSVVI
VEVTSQALRG ILSTERGQSA LSTFDSYERS LVEIHSRGVN MELVEKLLLG LERKFNVEAI
PLEKSEVWET SGKTFDKWIC PLVFSLIGHC DDVILRLCQD VVLLKVEVAE LLLPYIVVNL
GRKGLDNDFS KMISSQVQEL IFAETNRLTK SIQVFLGVLN ELRLCYIMEG SASASVLSKR
ECSKVYWMSI DYLTVARSAA SCGSYFTSIM YVEHWCEENF NSLTLGRPDF SYSEKLPCHI
EILVSAITQV NEPDSLYGII QSHKLSSQII TFEHEGNWSK ALEYYDLQVR SKTMVPDDIC
SRTVLAESLP STAHPSSSAF DNVTRLGKPY KGIIRSLQKT GCSHVLDLYY QGLTSRRGQF
QCDEELYELQ YEAAWRARNW DFSSLSRSTS LSSGQQIRCD HFNESLHCCL RALQEGDLEE
FHGKLKDSKQ ELLWSVSHAS EESTEHLYST IIKLQILYHL GKAWDMRWRT FSSNEMKLYP
WKQKVFSEPS IPTMDQMVWL NSDWEWIVKR TELHMNLLEP FIAFRGVLLN ILSCKDSMVQ
HLLQSASTLR KGSRFSQAAA SLHEFKYLVV ERREPGSSLY WTGRLEEAKL LRAQGQNEMA
ISLAKYISEN FPLDEKASDV YRLIGKWLAE TRSSNSRTIL EKYLKHAVSL AADHKSTDKK
SIERQGQTHF HLAHYADALF RSYEERLTSN EWQAAMRLRK HKDLELEALV RRFKSSAKGE
KTDYSVKIQE LQKQLAMDKE EAKKLQDDRD NFLNLALEGY KRCLVIADKY DVRVVFRLVS
LWFSLSSRKN IVNSMLSTID EVQSYKFVPL VYQIASRMGS SKDSPGPQSF QFALISLVKK
MAMDHPYHTV FQLLALANGD RIKDKQRSRN SFVVDMDKKL AAENLLEELS SYHGAIIRQM
KQMVEIYIKL AELETRREDT SKKISLPREI RSLKELELVP VVTATFPIDR SCQYKEGSFP
YFKGLEDSIT VMIGINAPKV IECFGSDGHK YRQLAKSGND DLRQDAVMEQ FFGLVNTFLH
NHRDTRKRRL GVRTYKVIPF TPSAGVLEWV NGTLPLGDYL IGSMRNGGAH GRYGRGDWLY
LKCREYMNNE KDKRKAFQEV CKNFRPVMHH FFLERYSLPA DWFERRLAYT RSVATSSMVG
YIVGLGDRHS MNILIDQATA EVVHIDLGVA FEQGLMLKTP ERVPFRLTRD IIDGMGVTGV
EGVFRRCCEE TLSVMRTNKE ALLTIIEVFI HDPLYKWALS PLKALQRQKE TYDDLETSFE
DSQDEYEGNK DATRALMRVK QKLDGYEEGE MRSVHGQVQQ LIQDAIDPDR LCQLYPGWGA
WL
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