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Database: UniProt
Entry: A0A059ABI7_EUCGR
LinkDB: A0A059ABI7_EUCGR
Original site: A0A059ABI7_EUCGR 
ID   A0A059ABI7_EUCGR        Unreviewed;       373 AA.
AC   A0A059ABI7;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   05-JUN-2019, entry version 26.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|PIRNR:PIRNR036497, ECO:0000256|RuleBase:RU000579};
DE            Short=HDH {ECO:0000256|PIRNR:PIRNR036497};
DE            EC=1.1.1.3 {ECO:0000256|PIRNR:PIRNR036497, ECO:0000256|RuleBase:RU000579};
GN   ORFNames=EUGRSUZ_J00623 {ECO:0000313|EMBL:KCW50996.1};
OS   Eucalyptus grandis (Flooded gum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Myrtales; Myrtaceae; Myrtoideae;
OC   Eucalypteae; Eucalyptus.
OX   NCBI_TaxID=71139 {ECO:0000313|EMBL:KCW50996.1, ECO:0000313|Proteomes:UP000030711};
RN   [1] {ECO:0000313|Proteomes:UP000030711}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. BRASUZ1 {ECO:0000313|Proteomes:UP000030711};
RX   PubMed=24919147; DOI=10.1038/nature13308;
RA   Myburg A.A., Grattapaglia D., Tuskan G.A., Hellsten U., Hayes R.D.,
RA   Grimwood J., Jenkins J., Lindquist E., Tice H., Bauer D.,
RA   Goodstein D.M., Dubchak I., Poliakov A., Mizrachi E., Kullan A.R.,
RA   Hussey S.G., Pinard D., van der Merwe K., Singh P., van Jaarsveld I.,
RA   Silva-Junior O.B., Togawa R.C., Pappas M.R., Faria D.A.,
RA   Sansaloni C.P., Petroli C.D., Yang X., Ranjan P., Tschaplinski T.J.,
RA   Ye C.Y., Li T., Sterck L., Vanneste K., Murat F., Soler M.,
RA   Clemente H.S., Saidi N., Cassan-Wang H., Dunand C., Hefer C.A.,
RA   Bornberg-Bauer E., Kersting A.R., Vining K., Amarasinghe V., Ranik M.,
RA   Naithani S., Elser J., Boyd A.E., Liston A., Spatafora J.W.,
RA   Dharmwardhana P., Raja R., Sullivan C., Romanel E., Alves-Ferreira M.,
RA   Kulheim C., Foley W., Carocha V., Paiva J., Kudrna D.,
RA   Brommonschenkel S.H., Pasquali G., Byrne M., Rigault P., Tibbits J.,
RA   Spokevicius A., Jones R.C., Steane D.A., Vaillancourt R.E.,
RA   Potts B.M., Joubert F., Barry K., Pappas G.J., Strauss S.H.,
RA   Jaiswal P., Grima-Pettenati J., Salse J., Van de Peer Y.,
RA   Rokhsar D.S., Schmutz J.;
RT   "The genome of Eucalyptus grandis.";
RL   Nature 510:356-362(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|PIRNR:PIRNR036497,
CC         ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|PIRNR:PIRNR036497, ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; KK198762; KCW50996.1; -; Genomic_DNA.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000030711; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR022697; HDH_short.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF036497; HDH_short; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030711};
KW   Isoleucine biosynthesis {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRNR:PIRNR036497, ECO:0000256|PIRSR:PIRSR036497-2,
KW   ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030711};
KW   Threonine biosynthesis {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN       10    156       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      168    366       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   NP_BIND      10     15       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   ACT_SITE    236    236       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR036497-1}.
FT   BINDING     137    137       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     221    221       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR036497-2}.
SQ   SEQUENCE   373 AA;  40251 MW;  55E1664700607619 CRC64;
     MKKMTLLLMG CGGVGRQLLR HIVSCRSLHA TQGVHLRVVG VCDSKSLVVV APDAHMLELD
     DKFLLEVCRV KEDGSSLSKL SGFGACRVFA HSELTAKVFN MVSHLGLAVV DCSASSETTE
     ILSRAIDLGC CIVLANKKPL TATMEYYDKL VSQPRRIRHE STVRAGLPII ASLNRILSSG
     DPVHRLVGSL SGTLGYVMSE VEDGKPLSQV VKTAKSLGYT EPDPRDDLGG MDVARKALIL
     ARLLGRRITM DSIKVESLYP DEMGPTVMSV DDFLSKGLPL LDTSICKRVA KASVSGKVLR
     YVCVIEGTRC EVGIQELPRD SPLGRLRGSD NVLEVYTRCY NKQPLVIQGA GAGNDTTAAG
     VLADILDIQD LFP
//
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