ID A0A059AGJ5_EUCGR Unreviewed; 472 AA.
AC A0A059AGJ5;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=HD domain-containing protein {ECO:0000259|PROSITE:PS51831};
GN ORFNames=EUGRSUZ_J02205 {ECO:0000313|EMBL:KCW52874.1};
OS Eucalyptus grandis (Flooded gum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Myrtales; Myrtaceae; Myrtoideae; Eucalypteae; Eucalyptus.
OX NCBI_TaxID=71139 {ECO:0000313|EMBL:KCW52874.1};
RN [1] {ECO:0000313|EMBL:KCW52874.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf extractions {ECO:0000313|EMBL:KCW52874.1};
RA Schmutz J., Hayes R., Myburg A., Tuskan G., Grattapaglia D., Rokhsar D.S.;
RT "The genome of Eucalyptus grandis.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-
CC deoxyribonucleoside + H(+) + triphosphate; Xref=Rhea:RHEA:46148,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18036,
CC ChEBI:CHEBI:18274, ChEBI:CHEBI:61560;
CC Evidence={ECO:0000256|ARBA:ARBA00001432};
CC -!- SIMILARITY: Belongs to the SAMHD1 family.
CC {ECO:0000256|ARBA:ARBA00005776}.
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DR EMBL; KK198762; KCW52874.1; -; Genomic_DNA.
DR RefSeq; XP_010033271.1; XM_010034969.2.
DR AlphaFoldDB; A0A059AGJ5; -.
DR STRING; 71139.A0A059AGJ5; -.
DR EnsemblPlants; KCW52874; KCW52874; EUGRSUZ_J02205.
DR GeneID; 104422602; -.
DR Gramene; KCW52874; KCW52874; EUGRSUZ_J02205.
DR KEGG; egr:104422602; -.
DR eggNOG; KOG2681; Eukaryota.
DR InParanoid; A0A059AGJ5; -.
DR OMA; DYIARDC; -.
DR OrthoDB; 5474479at2759; -.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008832; F:dGTPase activity; IBA:GO_Central.
DR GO; GO:0006203; P:dGTP catabolic process; IBA:GO_Central.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 3.30.70.2760; -; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR PANTHER; PTHR11373; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE; 1.
DR PANTHER; PTHR11373:SF4; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1; 1.
DR Pfam; PF01966; HD; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 75..213
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
SQ SEQUENCE 472 AA; 54419 MW; 0D3314709FEDE340 CRC64;
MGAYCNDDLS LSPAYSFASA RDLRLSKHVH DNVHGNIFLD PLALKFIDTE QFQRLRDLKQ
LGMTNMVYPG AVHSRFEHSL GVYWLAGEAV QKLKDYQGLE LGIDRFDIQT VKIAGLLHDV
GHGPFSHLFE REFLPLVLGG SNWHHEEMSV KIVDHIVDEH NIDIDPEMVK KVKEMILASS
EHSLPKGKKE KLFLYDIVAN GRNGIDVDKF DYIARDCRAC GLGCNFQFER LMETMRVLGD
EICYRAKEYL TIHKMFATRA DLYRTVYTHP KVKAVELMLV DALVKANDYL HISSYIHDPC
EYWKLDDSII KTIETAPDPE LKESRDLMLR IRRRNLYQFC NEYAVPKDKL EHFKAVTTQD
IVCSQKNTGV TLKEEDVAVT NVRIDLTRGR HNPLESINFF KDYESDEKFT IPDDRVSHLL
PTSYQDMIVR VYAKKPELVG AISDAFENFQ LKTYGIKAQV HSTPEKKKQR IS
//
