ID   A0A059AVL9_EUCGR        Unreviewed;       531 AA.
AC   A0A059AVL9;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=3-ketoacyl-CoA synthase {ECO:0000256|PIRNR:PIRNR036417};
DE            EC=2.3.1.- {ECO:0000256|PIRNR:PIRNR036417};
GN   ORFNames=EUGRSUZ_H00235 {ECO:0000313|EMBL:KCW57455.1};
OS   Eucalyptus grandis (Flooded gum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Myrtales; Myrtaceae; Myrtoideae; Eucalypteae; Eucalyptus.
OX   NCBI_TaxID=71139 {ECO:0000313|EMBL:KCW57455.1};
RN   [1] {ECO:0000313|EMBL:KCW57455.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Leaf extractions {ECO:0000313|EMBL:KCW57455.1};
RA   Schmutz J., Hayes R., Myburg A., Tuskan G., Grattapaglia D., Rokhsar D.S.;
RT   "The genome of Eucalyptus grandis.";
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-
CC         chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736;
CC         EC=2.3.1.199; Evidence={ECO:0000256|ARBA:ARBA00001906};
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005194, ECO:0000256|PIRNR:PIRNR036417}.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC       ECO:0000256|PIRNR:PIRNR036417}.
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DR   EMBL; KK198760; KCW57455.1; -; Genomic_DNA.
DR   RefSeq; XP_010069189.1; XM_010070887.2.
DR   AlphaFoldDB; A0A059AVL9; -.
DR   STRING; 71139.A0A059AVL9; -.
DR   EnsemblPlants; KCW57455; KCW57455; EUGRSUZ_H00235.
DR   GeneID; 104456150; -.
DR   Gramene; KCW57455; KCW57455; EUGRSUZ_H00235.
DR   KEGG; egr:104456150; -.
DR   eggNOG; ENOG502QPKZ; Eukaryota.
DR   InParanoid; A0A059AVL9; -.
DR   OMA; QVQRNSY; -.
DR   OrthoDB; 930987at2759; -.
DR   UniPathway; UPA00094; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009922; F:fatty acid elongase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00831; CHS_like; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR012392; 3-ktacl-CoA_syn.
DR   InterPro; IPR013747; ACP_syn_III_C.
DR   InterPro; IPR013601; FAE1_typ3_polyketide_synth.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR31561; 3-KETOACYL-COA SYNTHASE; 1.
DR   PANTHER; PTHR31561:SF208; 3-KETOACYL-COA SYNTHASE 2; 1.
DR   Pfam; PF08541; ACP_syn_III_C; 1.
DR   Pfam; PF08392; FAE1_CUT1_RppA; 1.
DR   PIRSF; PIRSF036417; 3-ktacl-CoA_syn; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|PIRNR:PIRNR036417};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transferase {ECO:0000256|PIRNR:PIRNR036417};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        67..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        100..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          119..408
FT                   /note="FAE"
FT                   /evidence="ECO:0000259|Pfam:PF08392"
FT   DOMAIN          425..505
FT                   /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08541"
SQ   SEQUENCE   531 AA;  59713 MW;  6B26D31F1A376FE4 CRC64;
     MAAEMAAEMA EQQEQISLQS LSQAFPISVE PQSQDSDRPS NPNLPSFLSS VRLKYVKLGF
     HYLISNAMYL LLVPLLGISS AHILTLTARD LAQLSDQLRF NLVTVVLFPA VMVFLGTPYF
     MTRPRKVYLV DFACYKPNPA QICTGEKFME ISELSTAFTE ENLAFQRKIF EKSGLGQRTY
     LPEAVLQVPP NLCMAEARAE AEAVMFGAID QLLPKTGVKA KDIGILVVNC SLFNPTPSLS
     SMIVNHYKLR GNVLSYNLGG MGCSAGLISI DLAKQLLQVQ RNSYALVVSI ESVTLNWYLG
     NDRSMLISNC LFRMGGAAIL LSNRSSDRRR SKYQLIHTVR THTGSDDKSY GCLFQQEDKK
     KKIGLSVSME LVAVIKEAIK TNITTLGPAV LPMSEQLWFF MTLVARKVFK MKIRPYIPDF
     KLAFKHFCIH VGGRPVLDEM EKSLELTKWH MEPSRMTLYR FGNTSSSSVW YELAYLEAKG
     RIRKGDRTWQ IAFGAGFKCN SAVWQALRTV DPAKENNPWM DDIHEFPVYV P
//