ID A0A059C6X8_EUCGR Unreviewed; 521 AA.
AC A0A059C6X8;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Granulins domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=EUGRSUZ_E02751 {ECO:0000313|EMBL:KCW74112.1};
OS Eucalyptus grandis (Flooded gum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Myrtales; Myrtaceae; Myrtoideae; Eucalypteae; Eucalyptus.
OX NCBI_TaxID=71139 {ECO:0000313|EMBL:KCW74112.1};
RN [1] {ECO:0000313|EMBL:KCW74112.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf extractions {ECO:0000313|EMBL:KCW74112.1};
RA Schmutz J., Hayes R., Myburg A., Tuskan G., Grattapaglia D., Rokhsar D.S.;
RT "The genome of Eucalyptus grandis.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; KK198757; KCW74112.1; -; Genomic_DNA.
DR RefSeq; XP_010057104.1; XM_010058802.2.
DR AlphaFoldDB; A0A059C6X8; -.
DR STRING; 71139.A0A059C6X8; -.
DR EnsemblPlants; KCW74112; KCW74112; EUGRSUZ_E02751.
DR GeneID; 104445011; -.
DR Gramene; KCW74112; KCW74112; EUGRSUZ_E02751.
DR KEGG; egr:104445011; -.
DR InParanoid; A0A059C6X8; -.
DR OMA; PNICEDG; -.
DR OrthoDB; 5472443at2759; -.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 2.10.25.160; Granulin; 1.
DR InterPro; IPR000118; Granulin.
DR InterPro; IPR037277; Granulin_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF950; PROBABLE THIOL PROTEASE-RELATED; 1.
DR Pfam; PF00396; Granulin; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00277; GRAN; 1.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR SUPFAM; SSF57277; Granulin repeat; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670}; Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..521
FT /note="Granulins domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018596501"
FT DOMAIN 57..115
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 151..371
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT DOMAIN 415..472
FT /note="Granulins"
FT /evidence="ECO:0000259|SMART:SM00277"
FT REGION 376..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 521 AA; 57561 MW; 3AE796B77A7E315A CRC64;
MGSSPRTHHQ LGLAILVFAS LARLSLSHAS LPSEYSIIGH GQDPNGAVSD ERAVELFRRW
QAQHKKVYKH AGEAERRLEN FKRNLRYVME RSRRDGGKQH GVGLNKFADL SNEEFRQLYL
SKVKKSVNQK WRAKRESLMR NKRKGAESCK APSSLDWRNY GIVTGVKDQG ECGSCWAFSS
TGAMEGINAL KSGDLISLSE QELVDCDTTN DGCDGGYMDY AFEWVINNGG IDSEEDYPYT
SVFGEGGICN VTKEEHNKAV TIDGYVDVYP SDDGLLCTVI QQPISVGMDG SAIDFQLYTG
GIYDGTCSAN PDDIDHAVLI VGYGSEGGED YWIVKNSWGT DWGVEGYFLI RRNTDLPFGV
CAINAMASYP TKESSAPSPY PSPVVPPPPP PPVTPPPPPP PKPTPPPPSP SPSECGDYSY
CPGDETCCCL YEFYNLCLVY GCCPYQNAVC CTGTDDCCPG DYPICDIEEG LCLKNAGDYL
GVASKKRKMA KRKLPWNRFE ENKNKIYQPL VWKRNRLAAI R
//
