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Database: UniProt
Entry: A0A059D3P7_EUCGR
LinkDB: A0A059D3P7_EUCGR
Original site: A0A059D3P7_EUCGR 
ID   A0A059D3P7_EUCGR        Unreviewed;      1841 AA.
AC   A0A059D3P7;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   05-JUN-2019, entry version 26.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=EUGRSUZ_B01945 {ECO:0000313|EMBL:KCW85109.1};
OS   Eucalyptus grandis (Flooded gum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Myrtales; Myrtaceae; Myrtoideae;
OC   Eucalypteae; Eucalyptus.
OX   NCBI_TaxID=71139 {ECO:0000313|EMBL:KCW85109.1, ECO:0000313|Proteomes:UP000030711};
RN   [1] {ECO:0000313|Proteomes:UP000030711}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. BRASUZ1 {ECO:0000313|Proteomes:UP000030711};
RX   PubMed=24919147; DOI=10.1038/nature13308;
RA   Myburg A.A., Grattapaglia D., Tuskan G.A., Hellsten U., Hayes R.D.,
RA   Grimwood J., Jenkins J., Lindquist E., Tice H., Bauer D.,
RA   Goodstein D.M., Dubchak I., Poliakov A., Mizrachi E., Kullan A.R.,
RA   Hussey S.G., Pinard D., van der Merwe K., Singh P., van Jaarsveld I.,
RA   Silva-Junior O.B., Togawa R.C., Pappas M.R., Faria D.A.,
RA   Sansaloni C.P., Petroli C.D., Yang X., Ranjan P., Tschaplinski T.J.,
RA   Ye C.Y., Li T., Sterck L., Vanneste K., Murat F., Soler M.,
RA   Clemente H.S., Saidi N., Cassan-Wang H., Dunand C., Hefer C.A.,
RA   Bornberg-Bauer E., Kersting A.R., Vining K., Amarasinghe V., Ranik M.,
RA   Naithani S., Elser J., Boyd A.E., Liston A., Spatafora J.W.,
RA   Dharmwardhana P., Raja R., Sullivan C., Romanel E., Alves-Ferreira M.,
RA   Kulheim C., Foley W., Carocha V., Paiva J., Kudrna D.,
RA   Brommonschenkel S.H., Pasquali G., Byrne M., Rigault P., Tibbits J.,
RA   Spokevicius A., Jones R.C., Steane D.A., Vaillancourt R.E.,
RA   Potts B.M., Joubert F., Barry K., Pappas G.J., Strauss S.H.,
RA   Jaiswal P., Grima-Pettenati J., Salse J., Van de Peer Y.,
RA   Rokhsar D.S., Schmutz J.;
RT   "The genome of Eucalyptus grandis.";
RL   Nature 510:356-362(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; KK198754; KCW85109.1; -; Genomic_DNA.
DR   STRING; 71139.XP_010046232.1; -.
DR   Proteomes; UP000030711; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR030559; PolZ_Rev3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   PANTHER; PTHR45812; PTHR45812; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030711};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030711};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      978   1105       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN     1246   1694       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1740   1813       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION      337    372       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A059D3P7}.
FT   REGION      865    926       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A059D3P7}.
FT   REGION      942    977       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A059D3P7}.
FT   COMPBIAS    337    370       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A059D3P7}.
FT   COMPBIAS    872    890       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A059D3P7}.
FT   COMPBIAS    905    924       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A059D3P7}.
SQ   SEQUENCE   1841 AA;  203995 MW;  A78290F5E14A5E78 CRC64;
     MGLLHLMRIR FRHPIPDTFA PKICIDNDQG RQVDLGRDAH LETPVWISST IPGSWRWQPL
     GSLDASSGDV AKRQSTCELE GDAGVDDIVN QQFKTYTSLS QARTDVKMVQ SLVPIWEEEF
     ERSGMHEAAL PPDHGKPPLE DVLKDLSHGL DLEHKLLELC SGVVSSGTPE QSMRPLSLIT
     APLDGGNSTE LALAGSSCDG RDLLLHLEEH ALNCSPSPPD LFCGDRMVAT PVKEKDACYK
     LSNKNKSSQL TQPSGVKAVD EEVLGLLKWL ATSQAAEDIN SDDELVRDII LTPLLPATTI
     EKVLEKANIE YESESQKECQ DILDSIDDMN DFGCSKERGT SSANFSSHSQ ASSEKSIPQV
     DGSSDGCCHS PSTGLEEGLL KMEKKVELKK FSQQQALDNN SKSSSNKKRK YSSLWGSLPF
     AMIPKVTSHP ELNSLNTNDG SAGGCENQNL ECSSSHSQRR LDYLSDIPTE KAESDAHLQE
     ASVFERCSVR DLMRKKRCHL FNPLDCTPHS EKRVNEFACP EEIDLLEHGN EYDTRQVGSC
     PDFQRESKEA CQENFTGSGM AITEGFLPVG IVKGPQQSPF EMHDPSLPLL FNEIDKTEGP
     VLKSKSVSDV PSSRGNKLLN TMESHSQDKF FKEKLHSVHV SSSVCETASA IKSETYHRNV
     HFNKSDHETG NLIERKALSH KNLEANEDTS LTLLRESLDC SDSELGPDVG FSGAATLMQT
     TVEAVEKPSP LIAMTIREKP PVADCGDEAP EHPILLNGKI KHSHSVVVEH DGHEGTSGRA
     LDEIPPFFVQ GFREDKEVQT DGITDGGSNY NKEAHMGVPT HYQNDGSCLY LLTPVISPPS
     ADIVNDWLRC SEKGTSGKNC IELMDSSPLK GSPVTPIHSQ ETSQDDVNGI MPESGSLPHA
     KPSIKQINQD KRGKLEKEED SSHNKAATMF INEKSIGRVK SHNCSQDISQ ISGPDGKSGS
     TPFSQLGYRD PASTGGGQQL TLLSIEVQAE SRGELRPDPR FDAINIVALA VMNDQDSVID
     VHVLVHCKTE SCQRSHDGVS SCEVLVFPQE NQLLIHFAKI VSKFDPDILV GWDVQSGSLG
     YLAERASYLG IGLLNMISRV PSDSKAFSGE SGLTDEGIAE NVLTEPLMFD SVRTGDAIIE
     DEWGRTHASG LHVGGRIVLN VWRLVRGEVK HNMYTVEAVA GVVLRRKIPS FQHSILTKWF
     SSGPGRARYR CLEYMIERAK LNVEIINQLD LVNRTAELAR VFGIDFFSVL SRGSQYRVES
     MFLRLAHTQN YIAISPGNQQ VASQPAMECL PLVMEPESGF YADPVIVLDF QSLYPSMIIA
     YNLCFCTCLG KVVPSKANTL GVTSFTADQY VLRDLKDQIL LTPNGVMYVP PKVRKGILPR
     LLEEILSTRI MVKQAMKRLT SPQQIIYRIF NSRQLALKLI ANVTYGYTAA GFSGRMPCAE
     LADSIVQCGR RTLENAISLV NAHDKWNAKV VYGDTDSMFV LLKGRTVKDA FRIGQEIVSA
     VNEMNPNPVA LKMEKVYHPC FLLTKKRYVG YSYESPDQIE PLFDAKGIET VRRDTCGAVA
     KTMEQSLRIY FEQQDISKVK AYLYRQWTRI LSGRVCLQDF VFAKEVRLGT YSTRPSSSLP
     PAAIVATKAM RIDSRAEPRY AERIPYVVVH GEPGARLVDM VVDPMEVLAI DSPFRLNELY
     YLKKQIIPTL QRVFGLVGAD LNQWFSEMPR PIRENFAKRP ISSPNPQRKR IDFYYLSKHC
     VLCGELVPTS AYLCNKCSHK RPAAATALVG RTSRVERDMQ HLAAICRQCG GGDWILESGV
     KCTSLACPVF YERRKVQKEL RGLSTVTTEA GLYPKCMVEW F
//
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