ID   A0A059D663_EUCGR        Unreviewed;       274 AA.
AC   A0A059D663;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=NADP-dependent oxidoreductase domain-containing protein {ECO:0000259|Pfam:PF00248};
GN   ORFNames=EUGRSUZ_B02640 {ECO:0000313|EMBL:KCW85934.1};
OS   Eucalyptus grandis (Flooded gum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Myrtales; Myrtaceae; Myrtoideae; Eucalypteae; Eucalyptus.
OX   NCBI_TaxID=71139 {ECO:0000313|EMBL:KCW85934.1};
RN   [1] {ECO:0000313|EMBL:KCW85934.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Leaf extractions {ECO:0000313|EMBL:KCW85934.1};
RA   Schmutz J., Hayes R., Myburg A., Tuskan G., Grattapaglia D., Rokhsar D.S.;
RT   "The genome of Eucalyptus grandis.";
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KK198754; KCW85934.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A059D663; -.
DR   EnsemblPlants; KCW85934; KCW85934; EUGRSUZ_B02640.
DR   Gramene; KCW85934; KCW85934; EUGRSUZ_B02640.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR   PANTHER; PTHR11732:SF543; ALDO_KETO REDUCTASE-RELATED; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   4: Predicted;
FT   DOMAIN          33..261
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        69
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         132
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            99
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   274 AA;  30397 MW;  17BC91DE83468891 CRC64;
     MRSGLAETIQ RSMANITVPN TRLNTNSKAI PLLGFGTAEY PFGSSDNVRE CLLDAIRLGY
     RHFDSAALYQ SEQPLGEAVA EALELGLVNS REELFITTKL WCSDAHGDRV VPALQTSLKN
     LGLEYVDLYL VHWPVCVKAG EYELPVKKED LLPFDYEGVW KAMEECQQLG LAKSIGVSNF
     SCKKLEKLLS ISEIPPAVNQ VEVNPLWQQQ KLRQFCNEKG IHITAYSPLG AKGTLWGSDR
     VMESEVLQEI AKAIGKTLAQ VVINVHAPSP SRIR
//