ID   A0A059DCZ8_EUCGR        Unreviewed;       615 AA.
AC   A0A059DCZ8;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=MGS-like domain-containing protein {ECO:0000259|PROSITE:PS51855};
GN   ORFNames=EUGRSUZ_A00733 {ECO:0000313|EMBL:KCW88344.1};
OS   Eucalyptus grandis (Flooded gum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Myrtales; Myrtaceae; Myrtoideae; Eucalypteae; Eucalyptus.
OX   NCBI_TaxID=71139 {ECO:0000313|EMBL:KCW88344.1};
RN   [1] {ECO:0000313|EMBL:KCW88344.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Leaf extractions {ECO:0000313|EMBL:KCW88344.1};
RA   Schmutz J., Hayes R., Myburg A., Tuskan G., Grattapaglia D., Rokhsar D.S.;
RT   "The genome of Eucalyptus grandis.";
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC       formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-
CC       1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route):
CC       step 1/1. {ECO:0000256|ARBA:ARBA00004954}.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; IMP
CC       from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step
CC       1/1. {ECO:0000256|ARBA:ARBA00004844}.
CC   -!- SIMILARITY: Belongs to the PurH family.
CC       {ECO:0000256|ARBA:ARBA00007667}.
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DR   EMBL; KK198753; KCW88344.1; -; Genomic_DNA.
DR   RefSeq; XP_010043217.1; XM_010044915.2.
DR   AlphaFoldDB; A0A059DCZ8; -.
DR   STRING; 71139.A0A059DCZ8; -.
DR   EnsemblPlants; KCW88344; KCW88344; EUGRSUZ_A00733.
DR   GeneID; 104432451; -.
DR   Gramene; KCW88344; KCW88344; EUGRSUZ_A00733.
DR   KEGG; egr:104432451; -.
DR   eggNOG; KOG2555; Eukaryota.
DR   InParanoid; A0A059DCZ8; -.
DR   OMA; SIVCGRF; -.
DR   OrthoDB; 3486892at2759; -.
DR   UniPathway; UPA00074; UER00133.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003937; F:IMP cyclohydrolase activity; IBA:GO_Central.
DR   GO; GO:0004643; F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity; IBA:GO_Central.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IBA:GO_Central.
DR   CDD; cd01421; IMPCH; 1.
DR   Gene3D; 3.40.140.20; -; 2.
DR   Gene3D; 3.40.50.1380; Methylglyoxal synthase-like domain; 1.
DR   HAMAP; MF_00139; PurH; 1.
DR   InterPro; IPR024051; AICAR_Tfase_dup_dom_sf.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   InterPro; IPR011607; MGS-like_dom.
DR   InterPro; IPR036914; MGS-like_dom_sf.
DR   InterPro; IPR002695; PurH-like.
DR   NCBIfam; TIGR00355; purH; 1.
DR   PANTHER; PTHR11692:SF0; BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC; 1.
DR   PANTHER; PTHR11692; BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH; 1.
DR   Pfam; PF01808; AICARFT_IMPCHas; 1.
DR   Pfam; PF02142; MGS; 1.
DR   PIRSF; PIRSF000414; AICARFT_IMPCHas; 1.
DR   SMART; SM00798; AICARFT_IMPCHas; 1.
DR   SMART; SM00851; MGS; 1.
DR   SUPFAM; SSF53927; Cytidine deaminase-like; 1.
DR   SUPFAM; SSF52335; Methylglyoxal synthase-like; 1.
DR   PROSITE; PS51855; MGS; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          86..235
FT                   /note="MGS-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51855"
SQ   SEQUENCE   615 AA;  66564 MW;  E07C6385567C8455 CRC64;
     MLGSPTAPTS SSAAAAAAAA VAAAFRSSLL HSTTTHRTRT CPSTSHQVPV ACVRLQSCSS
     SRAAPPIKAM AAEAEILSAP DKELRPSAPR SKQALISLSD KTDLAFLGKG LQELGYTVVS
     TGGTASALEN AGLSVSKVEQ LTCFPEMLDG RVKTLHPHIH GGILARRDQQ HHMEALDKHG
     IGTFDVVVVN LYPFYDKVTS AADIEFEDGI ENVDIGGPAM IRAAAKNHKD VLVVVDSHDY
     PALLEFLKSN GDDQQFRRKL AWKAFQHVAS YDSAVSEWLW RQTTGEKFPP SLTVPLSLKS
     SLRYGENPHQ KAAFYVDKSL AEVNGGGIAT AIQHHGKEMS YNNYLDADAA WNCVSEFSDP
     TCVVVKHTNP CGVASRGDIL EAYRLAVKAD PVSAFGGIVA FNVEIDENLA REIREFRSPT
     DGETRMFYEI VVAPKYSKKG LEVLRGKSKT LRILEAKKNE KGKLSLRQVG GGWLAQDSDD
     LTPADIQFNA VSGTTPQESE LEDAKLAWLC VKHVKSNAIV IVKNKCMLGM GSGQPNRLES
     LRIAMRKSGE EVKGAALASD AFFPFAWNDA VEEACQSGIA VIAEPGGSIR DQDAIECCNK
     YGISLVFTNV RHFRH
//