ID A0A059J356_TRIIM Unreviewed; 1522 AA.
AC A0A059J356;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Guanine nucleotide exchange factor {ECO:0008006|Google:ProtNLM};
GN ORFNames=H109_05789 {ECO:0000313|EMBL:KDB22311.1};
OS Trichophyton interdigitale (strain MR816).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=1215338 {ECO:0000313|EMBL:KDB22311.1, ECO:0000313|Proteomes:UP000024533};
RN [1] {ECO:0000313|EMBL:KDB22311.1, ECO:0000313|Proteomes:UP000024533}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MR816 {ECO:0000313|EMBL:KDB22311.1,
RC ECO:0000313|Proteomes:UP000024533};
RG The Broad Institute Genomics Platform;
RA Cuomo C.A., White T.C., Graser Y., Martinez-Rossi N., Heitman J.,
RA Young S.K., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., Martinez D., Murphy C., Pearson M.D.,
RA Persinoti G., Poon T., Priest M., Roberts A.D., Saif S., Shea T.D.,
RA Sykes S.N., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Trichophyton interdigitale MR816.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KDB22311.1}.
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DR EMBL; AOKY01000361; KDB22311.1; -; Genomic_DNA.
DR STRING; 1215338.A0A059J356; -.
DR HOGENOM; CLU_001471_0_0_1; -.
DR OMA; ICNYATM; -.
DR Proteomes; UP000024533; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF364; GUANINE NUCLEOTIDE EXCHANGE FACTOR LTE1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 2.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000024533}.
FT DOMAIN 250..375
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1275..1519
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 896..932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1161..1259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..507
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..606
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..979
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..1002
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1211..1233
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1234..1259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1522 AA; 166869 MW; B7A0DBB8D6533114 CRC64;
MNSNSPSYSV PGPRRHSVAK SQNINSQGPS LREVKSSDEV LAQCRRGPSH GRQFTVANVG
NNGRLYLRPI TNRSYTPHTL SPAPSIPEIT AAGHRASVWS NSQFSYLVDP PDTTSRGPAQ
TYHPLRRWKS LPTIDDVPPS PTRGALKVVI EGSEPVEKTP PKLPGPARKL EDFKFPEKHA
SAYRPAHRPP RLSSPISMGK MAGSSVHKTV VDKGAGQSVF YKLQEPIEPS IFDDLLPIMH
DASVVRYSKQ TKQLSAATPA RIVAQISSES FMDYELVSDF FLTFRSYLSP SNLLSLLLAR
LEWAINRRED DGRIIRIRVF AALRHWILNY FIDDFVASDS LRAQFCSRIN FLYENLKCRN
SRDVSDTKII LDLKRCWNGR CAQCWDDPEF VNDPRPEEPI VPGTNKPSSR PNGDGLCFSY
SELVTQDTSA SQTRKGSLVS VNDFNKSPLP AQTAFNQAIF NTPYSRLSLR DNSVSNQGRG
VHVVPDPIPK LNGPFRPPAP PSPRSPIWRW PLHSHTQSSH SHKRSGSFSD SFRDDRAPLP
QTQSNLNIES GAAGLGSLSQ FPIEATTSPG GINISIIRGS MLTPLEPDVP TTRPLSPPPD
PSMPRLRPPS SSSFLPSASA AASFSRMESP TKAAPGVKTF ISSLRRVLYS SASSAGTASS
STVFNKPEPR PIVSAHGKTS LLPPNVVFGS DRYREKRPGI KSPSRIDVLC DRTYQSYGTL
VNQMPLATSA APRSPSPKTQ PRAEISASLP VPNFSRGASS QITTGSQSIL IVDDTGARVG
TSGGLSLLPE EFQMYYPGSG QADPEPEIDP LTPIPLSMPG KDKLEVTPMS THHENVPIRK
PASRLRKYAS YQSVLGGRGG QRPASDMPRT DNTDMGACRG SFLPVHMPVA RGIQLPEKRL
RRRPGGDLRK MQTTMGSEEP GLSTGPDRDL NKFRFASGTT ATDSTSSALY ITHASNMDSI
SQSEDYDDDD YDDDDIDFST SSSALDSFSR SGTRSHSSPQ PPPTRHIFED AVAGFRKIPD
LPDGGIESAL LKLEGRWKGD TVARPNNGPS AGFSDTARRG SRQAHPDESA NNPDVNAGSE
APAYPEHQAV SNPNGTESYL GSDYSYSSIP LLERGLGDES MKTPTVPNFE NPSPLGQNVV
SNHPSIEVVE KTDSINRIVH GATTPEPIGD KHIDDSVSEL SSELSIDEGP TRKPSDPTHP
LAEPSTIAPS FLQPTPLPPY HQYLDPPFPN QHPDFPQNFS RPRNNSHPSI APTTPTHASH
ALPSSGHIAF ILAHDSPTLA KQFTIVEQAA LSEVDWKDLV DMRWTHSCPS PLNWVDYLSA
GVDRKGIDMV VARFNLMVKW AVSEVVLTKN ITERALVITK LIHIAVNARK LRNYATMLQM
VIALSSVDCT RLVKTWERVS ETEKEILAEM ELLIQPIRNF HKLRSEMESS VQDGCIPFVG
LYVQDLTYNA QKPAQIASTR DGEPLVNFER YHTAAAIVKS LLRLIDASTK YVFEPVPGVL
ERCLWIAALA DDDIKAFSKA IE
//
