ID A0A059J768_TRIIM Unreviewed; 1408 AA.
AC A0A059J768;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Vacuolar import and degradation protein 21 {ECO:0000256|ARBA:ARBA00029670};
GN ORFNames=H109_04424 {ECO:0000313|EMBL:KDB23670.1};
OS Trichophyton interdigitale (strain MR816).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=1215338 {ECO:0000313|EMBL:KDB23670.1, ECO:0000313|Proteomes:UP000024533};
RN [1] {ECO:0000313|EMBL:KDB23670.1, ECO:0000313|Proteomes:UP000024533}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MR816 {ECO:0000313|EMBL:KDB23670.1,
RC ECO:0000313|Proteomes:UP000024533};
RG The Broad Institute Genomics Platform;
RA Cuomo C.A., White T.C., Graser Y., Martinez-Rossi N., Heitman J.,
RA Young S.K., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., Martinez D., Murphy C., Pearson M.D.,
RA Persinoti G., Poon T., Priest M., Roberts A.D., Saif S., Shea T.D.,
RA Sykes S.N., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Trichophyton interdigitale MR816.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. {ECO:0000256|ARBA:ARBA00025178}.
CC -!- SIMILARITY: Belongs to the EAF1 family.
CC {ECO:0000256|ARBA:ARBA00008913}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KDB23670.1}.
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DR EMBL; AOKY01000297; KDB23670.1; -; Genomic_DNA.
DR STRING; 1215338.A0A059J768; -.
DR HOGENOM; CLU_001331_1_0_1; -.
DR OMA; KQQHASH; -.
DR Proteomes; UP000024533; Unassembled WGS sequence.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:UniProt.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR014012; HSA_dom.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR46459:SF1; E1A-BINDING PROTEIN P400; 1.
DR PANTHER; PTHR46459; E1A-BINDING PROTEIN P400-RELATED; 1.
DR Pfam; PF07529; HSA; 1.
DR Pfam; PF13921; Myb_DNA-bind_6; 1.
DR SMART; SM00573; HSA; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51204; HSA; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Reference proteome {ECO:0000313|Proteomes:UP000024533}.
FT DOMAIN 555..630
FT /note="HSA"
FT /evidence="ECO:0000259|PROSITE:PS51204"
FT DOMAIN 820..880
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT REGION 67..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1151..1190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1220..1239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1359..1408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 892..919
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 67..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..486
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1359..1386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1408 AA; 155190 MW; 3EAEDE6E6994AA8D CRC64;
MLSDRPLASR HDEIARCLWS RKRKLSELYY ATATFPHPSD TSGHREPLAR QKEAAFLDAN
DLSKGRLYDE NTLPERPRLE TVLAEYESKY GPPRPDKLDR PQTPVPQPAA GIASHEQPTQ
GGLAAGNDQP QLTVSSAGVQ TTEPPETVQS VPSVQHQPNG IDTSHPQHAA EAPAKPASSP
ETAVQATTQA TAHPLSPPET NRTSSFNDRL GVAPIIVPPK STEAASSPMS TGPSSSHTSA
TERSPASSST ESVASITESP SMGKHSTDES PSNVQSQPIS TAVPSTPDEQ LQLEAAMSIR
NSTTPKQPII AQDKDGDQHM AEAPSELKEP QLKREPTESV TNSRPSSSSG PQTAPDGKTA
TKPVEIQRQP AEQQHSRPER MTTRVASGAI RHKSVSEILG ESPKPGATPE TEQHSRDSRR
SSVFDRQTGT SHTSPASPSK LRLSERPDKE RSRLSTVVFP KTSSQEKEKA MQLASRRDEE
TRKSPNEEQD YLYTLFQAKA HYPPRTMSLN TLLSTAHKTL STSNHFLEYH EQMDCRTLKR
IYQLQHSNRW ALRQLQRSPE PPRQATHWDI MLDHVKWMRM DFREERKWKL TAAKRCAEWC
ADYVASDEDC RRSLRIPAKI PPPPATEAPE TDKLMDGHPD EVLPNNHPTP DLIHSADDDS
VSDGFNDEHP DFDDGNVPAA IFSSGSDEFT FRMERTIASE KILGELPFYC PVQIAPETNK
PAFKIQPDDV WKTQLLPVSK YAQGTIQFKE DGPPRKRSRY DYEQDTYYDG EEENGYRSLS
PEQVDVALFS PDYKALRDRI HPGNAFRPPT EYIMPPLGFY ESRQSSHWTL AEDDELRKLV
QEYSFNWSLI ASCLAPRSSF VSTSERRTPW ECFERWISLE GLPPDMAKTP YFRTYNARLE
AAQRTIMNAQ QQAVQQQQQQ QQNGGQVNPS AQALIRRRTA QPLRVERKRS SRHLALLAGM
RKLSQKRETN LQKQQHATQL ASMRKVNEAT QPRPPISTPQ EFSQLKHERE LKFLEKQEQY
RQQMIAHQRA AMAQRAAQLN PSGQFNGMPV RPPAAVPNGA GGVQVPIANG LANGIPNGAA
VSQSRPHPGM AAMPNGLPAT GPIPVPSGMS MKMMPQQGLQ QPINGRPGLP IQTSPDNSRI
IREANRLQEQ QRLLQSRQQQ HQFHGGQQGF APQQGPHSSP NMNATPATTS SNPALMAAFQ
AATNGGSPSF AASSLTPGVM PASSPRMNHP STSLNNAPSL PNVNNIQASL QRLHPTMSQE
QVSKLATERL QQYQQQRLSQ AALNAAAGNL GVGNLPSNYQ AGNSGQQIPQ QGTVNGVSSV
PMQNQTQGYM NRLGVSQAGG QQNRPGVGIA SPAMTNMLMH QSRSATPQSQ RPSSQGGPQQ
QQQPQQQQAQ PPPPGKSPKP AQAQTASS
//
