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Database: UniProt
Entry: A0A059KKH4_9BURK
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ID   A0A059KKH4_9BURK        Unreviewed;       372 AA.
AC   A0A059KKH4;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   31-JUL-2019, entry version 24.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=X805_26490 {ECO:0000313|EMBL:KDB51719.1};
OS   Sphaerotilus natans subsp. natans DSM 6575.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Sphaerotilus.
OX   NCBI_TaxID=1286631 {ECO:0000313|EMBL:KDB51719.1, ECO:0000313|Proteomes:UP000026714};
RN   [1] {ECO:0000313|EMBL:KDB51719.1, ECO:0000313|Proteomes:UP000026714}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6575 {ECO:0000313|EMBL:KDB51719.1,
RC   ECO:0000313|Proteomes:UP000026714};
RX   PubMed=24965827; DOI=10.1111/1574-6941.12372;
RA   Park S., Kim D.H., Lee J.H., Hur H.G.;
RT   "Sphaerotilus natans encrusted with nanoball-shaped Fe(III) oxide
RT   minerals formed by nitrate-reducing mixotrophic Fe(II) oxidation.";
RL   FEMS Microbiol. Ecol. 90:68-77(2014).
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KDB51719.1}.
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DR   EMBL; AZRA01000068; KDB51719.1; -; Genomic_DNA.
DR   RefSeq; WP_037482813.1; NZ_AZRA01000068.1.
DR   STRING; 1286631.X805_26490; -.
DR   EnsemblBacteria; KDB51719; KDB51719; X805_26490.
DR   PATRIC; fig|1286631.3.peg.2597; -.
DR   OrthoDB; 853329at2; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000026714; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000026714};
KW   Reference proteome {ECO:0000313|Proteomes:UP000026714};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       62    360       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
FT   REGION        1     31       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   372 AA;  40847 MW;  E28EDE09B1711DCA CRC64;
     MNAKTASGTD AWYPPVDKTS QTDDERIQDV TPLPPPEHLI RFFPIRGTAI ENLIGETRQS
     IRNIMQGKDD RLLVIIGPCS IHDPAAALEY ARRLKPLREK YKDTLEVVMR VYFEKPRTTV
     GWKGLINDPY LDESYRIDEG LRIARQLLID INRLGMPAGS EFLDVISPQY IGDLIAWGAI
     GARTTESQVH RELASGLSAP IGFKNGTDGN IRIATDAIQA AARPHHFLSV HKNGQVAIVE
     TRGNTDCHVI LRGGKAPNYD AASVAAACKD LEAAKLPATL MVDCSHANSS KQHERQIDVA
     RDIADQIAAG GRSVFGVMIE SHLKAGAQKF SPGKDDASKL EYGRSITDAC IGWDDSEQVL
     EILHRSILAR RG
//
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