ID   A0A059LHK7_9CHLO        Unreviewed;       529 AA.
AC   A0A059LHK7;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Pseudouridine synthase RsuA/RluA-like domain-containing protein {ECO:0000259|Pfam:PF00849};
GN   ORFNames=H632_c1818p1 {ECO:0000313|EMBL:KDD73813.1};
OS   Helicosporidium sp. ATCC 50920.
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Trebouxiophyceae;
OC   Chlorellales; Chlorellaceae; Helicosporidium.
OX   NCBI_TaxID=1291522 {ECO:0000313|EMBL:KDD73813.1, ECO:0000313|Proteomes:UP000026042};
RN   [1] {ECO:0000313|EMBL:KDD73813.1, ECO:0000313|Proteomes:UP000026042}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50920 {ECO:0000313|EMBL:KDD73813.1,
RC   ECO:0000313|Proteomes:UP000026042};
RX   PubMed=24809511;
RA   Pombert J.F., Blouin N.A., Lane C., Boucias D., Keeling P.J.;
RT   "A lack of parasitic reduction in the obligate parasitic green alga
RT   helicosporidium.";
RL   PLoS Genet. 10:E1004355-E1004355(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in RNA = a pseudouridine in RNA;
CC         Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC         Evidence={ECO:0000256|ARBA:ARBA00000073};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KDD73813.1}.
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DR   EMBL; AYPS01001818; KDD73813.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A059LHK7; -.
DR   STRING; 1291522.A0A059LHK7; -.
DR   OrthoDB; 5479603at2759; -.
DR   Proteomes; UP000026042; Unassembled WGS sequence.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR   PANTHER; PTHR21600:SF40; PSEUDOURIDYLATE SYNTHASE RPUSD2; 1.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000026042}.
FT   DOMAIN          123..356
FT                   /note="Pseudouridine synthase RsuA/RluA-like"
FT                   /evidence="ECO:0000259|Pfam:PF00849"
FT   REGION          240..279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          403..452
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        241..266
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   529 AA;  57896 MW;  733C3B46F7D16593 CRC64;
     MTGLAVRAAA AVEDGPPAPQ PGDYVYKDGL CLVRPYHFNF RCSVKARWEG STLAEAFARE
     FPGRPPAYYT WAIAHGKLHI EGELLSDPQA RIRAGQRLRH LVHRHEPPVL ACDPAVLGQT
     PDIVAVFKPA GLPVHETGPY RKNTLLARLR MLCPDLGPLY PVHRLDKPVG GVLLLARSPE
     AAEKMRVALE SRRDVRKRYV ARVQGEFLGG RRETLRVEVP LAWDRRGHHV YAAPGALAES
     EQSNFRANDG PAAGSEGAST STDAPAEEPL SLRGERRARA MAKKALKARR AASKEPCSDG
     IARSPTLAHV PACAEAPRAA VSEFRLLSVA PDRRTSLVEC VPLTGRTHQL RVHLQHLGHP
     IANDGQYGGR FEGPRNARLL AREMGIAWDA MRRQHGLEVW EHEAEAGQGS EEAEAGQGSD
     KAGKGTVPAQ KKARVDSLGA KASDSAPPRD EAHALHDKLI SDERFRIEEA EADPICPHCP
     LLSPRDYPLD LRPLWLFAVS YACGDWEFEA PLPGWAEESW VPEDPASST
//