ID A0A060HPI6_9ARCH Unreviewed; 288 AA.
AC A0A060HPI6;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Uroporphyrinogen-III synthase {ECO:0000313|EMBL:AIC17050.1};
DE EC=4.2.1.75 {ECO:0000313|EMBL:AIC17050.1};
GN Name=hemD {ECO:0000313|EMBL:AIC17050.1};
GN ORFNames=NVIE_027740 {ECO:0000313|EMBL:AIC17050.1};
OS Nitrososphaera viennensis EN76.
OC Archaea; Nitrososphaerota; Nitrososphaeria; Nitrososphaerales;
OC Nitrososphaeraceae; Nitrososphaera.
OX NCBI_TaxID=926571 {ECO:0000313|EMBL:AIC17050.1, ECO:0000313|Proteomes:UP000027093};
RN [1] {ECO:0000313|EMBL:AIC17050.1, ECO:0000313|Proteomes:UP000027093}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EN76 {ECO:0000313|EMBL:AIC17050.1};
RX PubMed=24907263; DOI=10.1099/ijs.0.063172-0;
RA Stieglmeier M., Klingl A., Alves R.J., Rittmann S.K., Melcher M.,
RA Leisch N., Schleper C.;
RT "Nitrososphaera viennensis gen. nov., sp. nov., an aerobic and mesophilic,
RT ammonia-oxidizing archaeon from soil and a member of the archaeal phylum
RT Thaumarchaeota.";
RL Int. J. Syst. Evol. Microbiol. 64:2738-2752(2014).
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DR EMBL; CP007536; AIC17050.1; -; Genomic_DNA.
DR RefSeq; WP_075055685.1; NZ_CP007536.1.
DR AlphaFoldDB; A0A060HPI6; -.
DR STRING; 926571.NVIE_027740; -.
DR GeneID; 74948010; -.
DR KEGG; nvn:NVIE_027740; -.
DR HOGENOM; CLU_011276_9_5_2; -.
DR OrthoDB; 15395at2157; -.
DR Proteomes; UP000027093; Chromosome.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR40082; BLR5956 PROTEIN; 1.
DR PANTHER; PTHR40082:SF1; BLR5956 PROTEIN; 1.
DR Pfam; PF02602; HEM4; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
PE 4: Predicted;
KW Lyase {ECO:0000313|EMBL:AIC17050.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000027093}.
FT DOMAIN 31..271
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 288 AA; 31541 MW; 19BBB2513129389F CRC64;
MEEEKEEAVA RVPGLEGKVL AITRGRKEAA EFSRLVKKEG GKAVPIQAIE IVPEGRKAAR
QFLKLLEEKK HDYCAFMSAQ AVAVLFELGG KERIASALES TEVIAVGPKT KQELEKRGVR
VAMMPKAFSS IGLVELLSSS SSSSSKDSHR GKKIIIPRSA EAGDYAAKAL LDLGMAAVDE
VFLYSVRTAS ITPAWKKFYR MLLDREIDAI VFTSASNVRS FFEIVDRLGG VRVDRLVQAV
VSIGPFTSAE LKRRKVRHRE AKHHTVEGTV QAAKKLLVNT TSTTSRSG
//
