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Database: UniProt
Entry: A0A060JE83_9MICO
LinkDB: A0A060JE83_9MICO
Original site: A0A060JE83_9MICO 
ID   A0A060JE83_9MICO        Unreviewed;       317 AA.
AC   A0A060JE83;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   11-DEC-2019, entry version 26.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=Rhola_00000660 {ECO:0000313|EMBL:AIC46897.1};
OS   Rhodoluna lacicola.
OC   Bacteria; Actinobacteria; Micrococcales; Microbacteriaceae; Luna cluster;
OC   Luna-1 subcluster; Rhodoluna.
OX   NCBI_TaxID=529884 {ECO:0000313|EMBL:AIC46897.1, ECO:0000313|Proteomes:UP000067708};
RN   [1] {ECO:0000313|EMBL:AIC46897.1, ECO:0000313|Proteomes:UP000067708}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MWH-Ta8 {ECO:0000313|EMBL:AIC46897.1,
RC   ECO:0000313|Proteomes:UP000067708};
RX   PubMed=24984700; DOI=10.1099/ijs.0.065292-0;
RA   Hahn M., Schmidt J., Taipale S.J., Doolittle W.F., Koll U.;
RT   "Rhodoluna lacicola gen. nov., sp. nov., a planktonic freshwater bacterium
RT   with stream-lined genome.";
RL   Int. J. Syst. Evol. Microbiol. 64:3254-3263(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934; EC=4.2.1.51;
CC         Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
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DR   EMBL; CP007490; AIC46897.1; -; Genomic_DNA.
DR   RefSeq; WP_038501559.1; NZ_CP007490.1.
DR   STRING; 529884.Rhola_00000660; -.
DR   EnsemblBacteria; AIC46897; AIC46897; Rhola_00000660.
DR   KEGG; rla:Rhola_00000660; -.
DR   PATRIC; fig|529884.3.peg.62; -.
DR   KO; K04518; -.
DR   OrthoDB; 1280729at2; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000067708; Chromosome.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00857; PREPHENATE_DEHYDR_1; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Lyase {ECO:0000256|RuleBase:RU361254, ECO:0000313|EMBL:AIC46897.1};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000067708}.
FT   DOMAIN          13..196
FT                   /note="Prephenate dehydratase"
FT                   /evidence="ECO:0000259|PROSITE:PS51171"
FT   DOMAIN          212..290
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
FT   SITE            189
FT                   /note="Essential for prephenate dehydratase activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001500-2"
SQ   SEQUENCE   317 AA;  33744 MW;  5945F8FA48A5AD00 CRC64;
     MSSASRNGST KKTYSFLGPI GTFTELALAQ VAEAKGAIAH PVSHVQDAID DVIAGRAFRA
     IIPVENSVEG GVTATSDALA ANPNIRIYGE YLVPVKFDLV ARPGVALTDV RVVATHPVAY
     AQTRAWLSAN IKKHTYLQST STAAAAADLL DTDGDHSIAD AAVAASTITK HYKLKVLAKN
     IGDNKNAQTR FLQIGLAKGA APKATGKDKT SVIVELPNDR PGALLEMLEQ FAARGVNLSR
     IESRPIGDQL GRYRFNIDIE GHVEDAAVAE ALKGLHRFSP KVIFLGSYPR ADKKKSVHQG
     NNTNAAFAAA EKWIAKL
//
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