ID A0A060M1I6_9BACI Unreviewed; 301 AA.
AC A0A060M1I6;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:AIC95885.1};
GN ORFNames=BleG1_3338 {ECO:0000313|EMBL:AIC95885.1};
OS Shouchella lehensis G1.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Shouchella.
OX NCBI_TaxID=1246626 {ECO:0000313|EMBL:AIC95885.1, ECO:0000313|Proteomes:UP000027142};
RN [1] {ECO:0000313|EMBL:AIC95885.1, ECO:0000313|Proteomes:UP000027142}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G1 {ECO:0000313|EMBL:AIC95885.1,
RC ECO:0000313|Proteomes:UP000027142};
RX PubMed=24811681; DOI=10.1016/j.gene.2014.05.012;
RA Noor Y.M., Samsulrizal N.H., Jema'on N.A., Low K.O., Ramli A.N.,
RA Alias N.I., Damis S.I., Fuzi S.F., Isa M.N., Murad A.M., Raih M.F.,
RA Bakar F.D., Najimudin N., Mahadi N.M., Illias R.M.;
RT "A comparative genomic analysis of the alkalitolerant soil bacterium
RT Bacillus lehensis G1.";
RL Gene 545:253-261(2014).
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DR EMBL; CP003923; AIC95885.1; -; Genomic_DNA.
DR RefSeq; WP_038483317.1; NZ_CP003923.1.
DR AlphaFoldDB; A0A060M1I6; -.
DR STRING; 1246626.BleG1_3338; -.
DR KEGG; ble:BleG1_3338; -.
DR PATRIC; fig|1246626.3.peg.3315; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_1_0_9; -.
DR OrthoDB; 9786703at2; -.
DR Proteomes; UP000027142; Chromosome.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0046487; P:glyoxylate metabolic process; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006398; Tartro_sem_red.
DR NCBIfam; TIGR01505; tartro_sem_red; 1.
DR PANTHER; PTHR43060:SF3; 2-HYDROXY-3-OXOPROPIONATE REDUCTASE; 1.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000027142}.
FT DOMAIN 4..163
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 166..285
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 172
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 301 AA; 31506 MW; BA57EC4B35DCA86B CRC64;
MNKRVGFIGL GIMGMPMTRN LLKAGFSVTA FDLNQEAVKA IAAEGAVAAS SGKEVAQNSD
VIITMLPKGE HVRAAVFGVN GVMEGAEQGL IIVDMSSVSP VDSKQMAAHA AEKGVHFLDA
PVSGGEPKAI DGTLAIMVGG EEDVFAQAKP VLEAMGTDIV LVGDAGCGTT AKLANQIIVN
LNIAAVSEAL VLASKAGIDI EKMYQAIRGG LAGSTVMDAK IPMILDRNFV AGGRIDINMK
DLTNVMNTAH EMHVPLPLSS QLLEIFHSLS ADGKQAIDHG GIVQHYEKLA NVIVQRKEDK
E
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