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Database: UniProt
Entry: A0A060NTI5_9BURK
LinkDB: A0A060NTI5_9BURK
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ID   A0A060NTI5_9BURK        Unreviewed;       366 AA.
AC   A0A060NTI5;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   08-MAY-2019, entry version 22.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   Name=aroF {ECO:0000313|EMBL:BAO82224.1};
GN   ORFNames=SRAA_2370 {ECO:0000313|EMBL:BAO82224.1};
OS   Serpentinomonas raichei.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Serpentinomonas.
OX   NCBI_TaxID=1458425 {ECO:0000313|EMBL:BAO82224.1, ECO:0000313|Proteomes:UP000067461};
RN   [1] {ECO:0000313|EMBL:BAO82224.1, ECO:0000313|Proteomes:UP000067461}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A1 {ECO:0000313|EMBL:BAO82224.1,
RC   ECO:0000313|Proteomes:UP000067461};
RX   PubMed=24845058; DOI=10.1038/ncomms4900;
RA   Suzuki S., Kuenen J.G., Schipper K., van der Velde S., Ishii S.,
RA   Wu A., Sorokin D.Y., Tenney A., Meng X.Y., Morrill P.L., Kamagata Y.,
RA   Muyzer G., Nealson K.H.;
RT   "Physiological and genomic features of highly alkaliphilic hydrogen-
RT   utilizing Betaproteobacteria from a continental serpentinizing site.";
RL   Nat. Commun. 5:3900-3900(2014).
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; AP014568; BAO82224.1; -; Genomic_DNA.
DR   RefSeq; WP_045532950.1; NZ_AP014568.1.
DR   EnsemblBacteria; BAO82224; BAO82224; SRAA_2370.
DR   KEGG; cbaa:SRAA_2370; -.
DR   KO; K01626; -.
DR   OrthoDB; 853329at2; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000067461; Chromosome.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000067461};
KW   Reference proteome {ECO:0000313|Proteomes:UP000067461};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       59    350       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   366 AA;  39484 MW;  2BFAC2BB68765676 CRC64;
     MQHVPPHPPA PGTLDHTRID DLRIAAVRPL LTPALLQEWL PLPEAGAALV ERSRAAITRL
     LQGQDDRLLV VVGPCSIHDH DQALEYARLL QTQAAALAPE LLLVMRVYFE KPRTTVGWKG
     YINDPHLDGS FAINEGLERA RQLLLDILAL GLPVGTEFLD LLSPQFISDL VTWGAIGART
     TESQSHRQLA SGLSCPVGFK NGTDGGVQVA VDALQAAAAA HAFMGMTKMG QAAIFETRGN
     ADCHLILRGG PQPNYAAADV QASCARLRAA GLRQQLMIDF SHANSRKQPL RQLEVGADVA
     AQIAAGERRI LGVMIESHLH EGRQDLVAGQ PLRHGVSLTD ACLGFEQTVP LLQQLAAAVR
     QRRLAL
//
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