ID A0A060PZB9_9RICK Unreviewed; 572 AA.
AC A0A060PZB9;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000256|ARBA:ARBA00015325, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000256|ARBA:ARBA00033342, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000256|ARBA:ARBA00033245, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000256|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000256|HAMAP-Rule:MF_01810,
GN ECO:0000313|EMBL:BAP00094.1};
GN ORFNames=WCLE_008010 {ECO:0000313|EMBL:BAP00094.1};
OS Wolbachia endosymbiont of Cimex lectularius.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Wolbachieae; Wolbachia.
OX NCBI_TaxID=246273 {ECO:0000313|EMBL:BAP00094.1, ECO:0000313|Proteomes:UP000031663};
RN [1] {ECO:0000313|EMBL:BAP00094.1, ECO:0000313|Proteomes:UP000031663}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=wCle {ECO:0000313|Proteomes:UP000031663};
RX PubMed=24982177; DOI=10.1073/pnas.1409284111;
RA Nikoh N., Hosokawa T., Moriyama M., Oshima K., Hattori M., Fukatsu T.;
RT "Evolutionary origin of insect-Wolbachia nutritional mutualism.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:10257-10262(2014).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000256|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000256|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01810};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01810}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000256|ARBA:ARBA00010527, ECO:0000256|HAMAP-Rule:MF_01810}.
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DR EMBL; AP013028; BAP00094.1; -; Genomic_DNA.
DR RefSeq; WP_041045947.1; NZ_AP013028.1.
DR AlphaFoldDB; A0A060PZB9; -.
DR STRING; 246273.WCLE_008010; -.
DR KEGG; wcl:WCLE_008010; -.
DR HOGENOM; CLU_016535_1_0_5; -.
DR OrthoDB; 9780552at2; -.
DR Proteomes; UP000031663; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd20070; 5TM_YidC_Alb3; 1.
DR CDD; cd19961; EcYidC-like_peri; 1.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR InterPro; IPR047196; YidC_ALB_C.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR NCBIfam; TIGR03593; yidC_nterm; 1.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PRINTS; PR01900; YIDCPROTEIN.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|HAMAP-Rule:MF_01810};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01810};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01810}.
FT TRANSMEM 359..378
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 428..451
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 471..500
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 521..543
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT DOMAIN 69..347
FT /note="Membrane insertase YidC N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14849"
FT DOMAIN 359..556
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
SQ SEQUENCE 572 AA; 66020 MW; E082BD8177D8061D CRC64;
MSEARNLILA VVLSVLIMVS WRVIYDNFLN TDQDHPSIEN IEHIESFNDL APIIHQNRSE
IINSTQEQRI SLTNSMVKGS ISLKGARFDD LILTNYHLEP NYSSPQVMLL SPAESEDVYF
AEFGWLDPSD KIKVPDSKMV WQADKTELTN QKAINLFWDN ENGILFKMKI SLDNNYMFKV
EQIIENNTKD NVILVPYGKI NRKRGDINES YWISHEGVIG AFDNKLEEWT YKDVAKKHLI
KASTSEKNWF GFADKYWLTA IIPEKSDKIN VSIKHTNVNN IDKFQVDFVK PYKSILPGTS
VSNVNYFFAG AKKLNLLDSY KSTLGIPLFD KAVDFGVLYF ITKPVFLLLE YFNFVLKNFG
LAILLLTLVI KLLMLPLSNR SYVSMFKMKN LQPEVVRIRE LYKDDSLRQH KEIIALYKKN
NVNPMSSILP MVVQVPVFFA LYKVLFVTIE MRHAPFYLWI KDLSAPDPTN IFTLFGLFSY
NFPISIGILP IILGVTMIIQ QKISEKDQIN RDDVQMNVMR FLPYISIFIF SSFPSGLVIY
WIFSNVMTLI QQSLIKLFLT RKGGINVENT NS
//
