ID A0A060S607_PYCCI Unreviewed; 5011 AA.
AC A0A060S607;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=BN946_scf184884.g61 {ECO:0000313|EMBL:CDO69902.1};
OS Pycnoporus cinnabarinus (Cinnabar-red polypore) (Trametes cinnabarina).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Polyporaceae; Trametes.
OX NCBI_TaxID=5643 {ECO:0000313|EMBL:CDO69902.1, ECO:0000313|Proteomes:UP000029665};
RN [1] {ECO:0000313|EMBL:CDO69902.1, ECO:0000313|Proteomes:UP000029665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BRFM137 {ECO:0000313|EMBL:CDO69902.1,
RC ECO:0000313|Proteomes:UP000029665};
RA Levasseur A., Lomascolo A., Ruiz-Duenas F.J., Uzan E., Piumi F., Kues U.,
RA Ram A.F.J., Murat C., Haon M., Benoit I., Arfi Y., Chevret D., Drula E.,
RA Kwon M.J., Gouret P., Lesage-Meessen L., Lombard V., Mariette J.,
RA Noirot C., Park J., Patyshakuliyeva A., Wieneger R.A.B., Wosten H.A.B.,
RA Martin F., Coutinho P.M., de Vries R., Martinez A.T., Klopp C.,
RA Pontarotti P., Henrissat B., Record E.;
RT "The genome of the white-rot fungus Pycnoporus cinnabarinus: a
RT basidiomycete model with a versatile arsenal for lignocellulosic biomass
RT breakdown.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDO69902.1}.
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DR EMBL; CCBP010000057; CDO69902.1; -; Genomic_DNA.
DR STRING; 5643.A0A060S607; -.
DR HOGENOM; CLU_000050_0_2_1; -.
DR OMA; ILEQWHR; -.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000029665; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 8.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 2.
DR SMART; SM00382; AAA; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000029665}.
FT DOMAIN 4790..5008
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 4130..4644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4659..4693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4174..4191
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4206..4234
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4244..4306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4307..4327
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4362..4404
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4445..4460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4471..4485
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4517..4536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4544..4562
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4659..4674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5011 AA; 554992 MW; 57EB4670DD44060E CRC64;
MADSAESFED PLRLNLHGQT QKLLGQLPPE STYAAVLKNA ASRAALLETL SELMLKPPLT
MLIAKLFRPL LMDLCARWLY RDPDDVHIFE ALCLLLDIHP EIYPILSKFL RTPELAHGPL
ALILQSQTLS DREPRSFHAT LLAYYRLLQA HRTLPLSLGW SLSPLSQLLK DPHSDNGTKL
LAARCFALHS SMLEGERVKL EKELVGDVQE VDCPVQYAYS LDGTVREVDG WVLPILEMER
VSRARDAILD DQGFYVCKDS DSSEPIHPAE LSPLLVNVHG VLMLRSSAST DMAPQLIDTP
TAVQALRQVA LHLSTQLPIL LTSAPSAGKS LLISHLAQLL YPQVQNCIVP IHLADTSLDP
RSLLGSYVSS PTRPGTFEWK EGVLVRAMRE GKWVVLEDID RATMEVLGIV KPLIESLGAD
KWIGGRARLD IPGRGTVEAQ DSFAVFATRS IQPSRKGSFP APTFYGAHKL YEVILNSPSA
TDLRMIIDAK FPRLAGAPAQ GLINLWEGVR ALGTPASTRD VGLRELERFC TRISALLPST
TQSMDIDHDP TQQTDLVQLF PNPTVREDMF LEARDVFFGA GATTTAGRAH LAAVADVAAR
HLGISEERKE WILHNRTPEF DVEKDVNGRI TAMRAGRARL PARTSKMDIA PPITRPFAMH
KPATSLMARL ATAISLAEPI LLTGETGTGK TSVVTHLASL LRRPLISLNL SNQTESSDIL
GGFKPVDARI PGAELQQRFL DLFGGTFSRK KNAHFEESVR KAVQERKWKR AAGLWLEATK
MAKNRIQAKQ AEEDAKELEG GTPRKRRKVE SAGLKISMDA WDAFERDVQA FEVQHVQGKS
KFAFAFVEGP LVKALRNGDW ILLDELNLAT PETLESISGL LQGPTASITL TEQGSLEPVP
RHPDFRLFAC MNPATDVGKK DLPPNIRSRF TEIDVPPPDS DRETLLTIVA QYIGACAVGD
KGAIMDVAEF YSAVKRLAEE RQIADGSNHR PHFSMRTLAR ALTFAADMAP KYSLRRALWE
GCLMAFTMVL DGPSAAAVTA LAQKHILAGV RNSRSLLAKE TLPPSDPSAF VKFGPFYLER
GPVPEDPAED YIMTPSVEAK LIDLARIISA KRFPVLIEGP TSSGKTSSIE YLAQRTGHRF
VRINNHEHTD IQEYIGTYVS DPLTGKLVFK EGLLVRALRQ GDWIVLDELN LAPTDVLEAL
NRLLDDNREL VIPETQEVVR PHPHFMLFAT QNPPGLYAGR KVLSRAFRNR FLEVHFEDVP
QAELETILCR RCRIAPSYGQ RIVAVFRELQ KRRQSSRVFE SKQGFATLRD LFRWAGRDAI
SYEELAANGY MLLAERARRD DDKLVVKEVI ESIMKVRIDE SSLYDLKNPK FDPAAFLGCP
LPSYSQVVWT SAMQRLFVLT ARALRFNEPV LLVGETGCGK TSVCQLYAEV LGRTLKAVNC
HQNTETADLI GGLRPIRNKA AIEAETIRDA VALLAQCGVS DIAEDTSALT TAIDGLLKSG
SMATAQEASL RDMRARLQRL SAMFEWRDGP LVEAMRNGDV FLLDEISLAD DSVLERLNSV
LEPGRTIVLA ERGGADEEIP AIKASDDFKF VATMNPGGDY GKKELSPALR NRFTEIWVPP
ITDRRDLECI VETLWQHEVL KAYTKHLLDF VEWLCAAVND RAFANLRDIL AWIAFSNAAI
IRNADTLSPN AVFHHAAEMT FLDGLASMPQ LSAYSKEALL RLKAEASAKL HELVPLPSGS
NEVHTLSYDP SGARFGPFTI PRGPLEPSAQ SFSLEAPTTR DNVMRVVRAC QLQKPVMLEG
SPGVGKTSLV AALANMCGHH LCRINLSDQT DLVDLFGSDL PVEGGEPGQF AWKDAEFLRA
LQEGHWVLLD EMNLAPQSVL EGLNAVLDHR GTVYIPELGR SFVRHPSFRI FAAQNPLHQG
GGRKGLPKSF LNRFTKVYVQ EMSSTDLLLI CRNLFPNYPS HLLEKMIHYM AVLNEETMIK
RTFASEGAPW EFNLRDVIRW TTLLCQCDPP AHPSVFLSSI ILQRFRTSQD RDRARLLFTD
IFGPCELGEP EFILTASHLQ VGNHRSRRSG RLSALRGGRI LRTSASALES LGTCVSNGWL
AIVNGPKNCG KTTLIRTLAN LLGKTLQEVS INNATDATDI LGSFEETDLG YRVSVVLEGL
LGVLDDLLCS GTGWQLPMVS DHIALLRSSS RAVSDTSPQA VLRRLSQILA ELSGLPEPYA
SRCSSIRRDI QEIAEQGSKA GRLEWVDGPL VRALRDGHWL LLDGANLCNA SVLDRLNSLC
EMGGALTLNE RGAVNGEVQI LYPHPEFRLF MCADPQYGEL SRAMRNRGIE IALSAEPDVE
DWRRLLDHLR CSSRLASPSS DLRTSYTVYS GLRRGLQPLP ATSQISISWP SDQLLMEDSA
VAHAADIGPV IASSLAPASS NRAIFYYTAV NVVPDALAHL SRFLPYFGDG PATVMSTLEA
LLGVIACSDV YRNIVQMRRQ FSRSSQVPCD ILLAQPLYMD VANAVQKTTS ESLEEAPTLS
LRFLRLLAAV TADYDSAAKP RHGHSRVTAK RIDYSSPEAR AVDAAHRLIE TIKDASTTFL
SRSPFYASHS DVDALLAFAA YGRFLQGASP SAESFDFSLA LAVVEWMEQV FSIHDRSSTL
VDISRAASNL KAVVSLSTGT GLFDMWRKLS PEQTCSTQGD MLLRLEDAAR GLADVQRGIR
IRAQLLDLMS LWVVANASPE KNQSQITELN VEVAKIIQNL VDISCSDPGV PLSGLIPFKR
ISWTRDAGEW PIYIQLVGEW LSQIWTAAPI GELSGGSALC HPIELSDTVL ACNDELRSFS
GFAQYDFALR RRLAMRSGPL STNASRWSQM LALLMHTALL VVSSLSSSIM DQVGKSQGRS
LSMPMIMNIF DEVQDSRIAP VYETHLRSPF QALRDSLDES YLLLGHGWIG LSRFLLELYV
PNIPIDPSAI ERYSREYWDE QRILLEEELH LYREHEQRTS GRPDTLVTRY LSKELRRASE
RAAKGSKQVS PRSDTMKLHA YWTEVAQFLS HAASPANIDS IASSLRDRKI SSLMREQVFQ
ESTAAFSQRL DSAYPDFADV SGLLHLALLQ QRLGLRFIAD ANASPESSDV EGGRVAAALV
AFPSVCGSEA LRIVCQPAEP SFSLVLARLA AVASDVSSGV DLQTCLHSVE EIYEQSLGLW
LIDKARAEEA EREAQSLYRH KTDSNAPATD AELEEQEFLA LFPEFEDLLE ANTAPTAAQS
RKKPNTLVEA ADIRKLCVLH QHLFGNQRST LAIIDSDADF GALRKALTRD LLASEASHLP
ERLDQLSRPY QISLLLGRLS VLHGAASISS RPYNFYSDPS VPEIRKGLEV LQRMVDRLLT
LIEEWPEQMV LQHLKARCDA ILNLDIFSPV AKVLSAIEQL LLHMEDWEMY ANRENTLNAY
QHDLASLIVS WRRLELTSWQ GLLRTQAQEF AHGASEYWFR LYEATVRGVA SAVQEEDRGD
EGALAKYLDG LVPLLDTFMS STPLGQYSQR LAYLRAFEVY CKYYSGTLVG KRAAAFQSAH
RVLRFTCMYY AQFVPRVTSS LASQQEALEK EIRGFIKLAS WKDINVHALK QSAQRTHRQL
YKCVRKFREI LRQPVTPLLI PPAAGAEESA TSAARPTLHL IEGPLTFPAF PHHASHSEHL
LNLERTFKNF QSVVRGRIGA LIDTLSPTDV EDLSAEIITT MQSLASASVP NDVTGEQRDK
AQKALLVRKR KAWSDLLKEL KRIGLAMNVK PEVLEQQSNA RWLREQPIVV DPQTAVGPFE
KSETYLLRLS RLLPDLRSSL SNHNPDIGTR DLQRGINLVE SAFSLAVEAR ACFVDAVEQH
SRLQELSKRL HMIVEHPRIV ASGSAAQDRT VRIKEDLGRL VNALEETHGI WKQYLDELPD
TEVLPSAVQE LQSVIDSSKV FFSQVAEVST KVKLTPVPVL LENESEVIEQ ALDHVRSVCH
LLRGWTEGPN VVSIFASSVL EWLEKRDAFS NVQFEHNRRD IATDNTADLI DRLLLSAQGI
LAIPPPPAKS ESDMEETPDR FVRDYNRSIM QVTRALKLDG VASLLTSVVN EAVCTSPEEL
EKRLARALPF LDIYLELARV QLTNHCAWTK ALFKLDYVVC TVMRTIAQDG FCKPPDTGEA
EAGEGAMEDA GGVGLGEGTG KENVSKEIED ESQVEGLQGE AEEDEDVERA EEGNALEMSE
DFGGKMQDVE EEEGEEGEED DEEGSEEEPE EQLGNLDAAD PSAVDEKLWG DESGPDDTKQ
DQNQAAEDHS TKQQQDSETV AKEDEGRKES KEKQKEQPRE EGKEGEEGEE PAPEDAMQEE
EVQEEGEQDQ QGGAPLDEFV PEANTLDLPE DLDLGKDDGK EPELDDDIDM GGEEEEGEGL
EEEKPGEGID EGAEEDDAMD VEENPQALPE DGAQPENISE DVVDGATAQA DLHAGTGQDS
GEAGDQAMAD SNQGQGGQGP SSAGEAGGPE EETQEGEKLT QDSAAQEERP QEQSADATID
AADAVDEGKD HNGSARSHQG AVPSQMKSQP LQNNPLRSLG DALREISQRF DEILESEGPQ
ERTEQMDTSG APQLEYIRPE EDTGAEEMQA LGPAQQEDVA KLNELKFLDE ETQPTEDLQP
MEEDAPESAP EPSSRPPTST LHAEPTAQAI RDDVKSALTQ TEVRSQQSGQ AVTDLPEPHP
SDHLVPSEEE ELDAQKAVEL ALRQWQAEGQ PAAQAEEMWR KYESLTHDLS YALCEQLRLI
LEPTMATRLK GDYRTGKRLN MKKIIPYIAS EFTKDKIWLR RTRPSQREYQ VLIALDDSRS
MAESHSVHLA FQTLALVAKA LGRLEVGDVA IAKFGEGVDV LHGFDGGPFT DQAGTRVMGA
FHFDQKATQV LSLLETSLKM LEEARERRAM SSSSAADLWQ LEIIISDGIC QDHERLRTVL
RRAEEQRVMV VFIVLDSLHS KRTGGAGANE NSILSMNQVA YKMVDGRMDL QVKRYLDTFP
FDYYVVLRSV EALPDVLSGT LKQFFERVAE A
//
