ID A0A060VS40_ONCMY Unreviewed; 1311 AA.
AC A0A060VS40;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN ORFNames=GSONMT00074542001 {ECO:0000313|EMBL:CDQ57748.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ57748.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ57748.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ57748.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR EMBL; FR904291; CDQ57748.1; -; Genomic_DNA.
DR STRING; 8022.A0A060VS40; -.
DR PaxDb; 8022-A0A060VS40; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF32; SODIUM-DRIVEN CHLORIDE BICARBONATE EXCHANGER; 1.
DR Pfam; PF07565; Band_3_cyto; 2.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT SIGNAL 1..36
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 37..1311
FT /note="Anion exchange protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001588777"
FT TRANSMEM 681..703
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 715..738
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 758..780
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 787..809
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 897..917
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 929..950
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 982..1001
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1022..1046
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1082..1104
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1177..1194
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 217..319
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 484..607
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 652..1160
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 131..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..146
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1311 AA; 147312 MW; D9CDDF74B2894B09 CRC64;
MQDWWINGCS VVKINRGSEC AFVRLFLSSL LCRVCACPGS RGTQVLRSSA QPPDLGSAAL
LSTRGHLKDM FMHSAGGLGP KSRFYSLKRN DEEAVVDRGG YRSMVKTNFE KEELEGHRTL
YIGVHVPIGK KSHRRHRHHG HRHRKRSREL DSGVDNGRES PTYYTPSQRV QFLLGTEDDD
EEHIPHDLFT ELDEICLKDG EDAEWRETAR WLKFEEDVED GGERWSKPYV ATLSLHSLFE
LRSCILTGIV LLDMRASSVE EVADMVLDQQ ETVGPLGDEV RRKVRESLLK QHHHQNQKKL
ANRIPIVRSF ADKKQSEPQS MDKNVCLSSL VSLCVSVYVD ECVYVCLAGG PSLCSTLKSS
FWCSFMAAGS CSCGVSSWAA SLVNCLRLLS LSSCGTMSQN ESLQGMLLFL IISICYASDS
FCWLVNGSNT EISQVIPPQT SLPIPNDGKA DVSRENSAVD FSKADRITAE QRQEDQFFII
THVHMYVMMI DLHFMKKIPP GAEASNVLVG EAEFLDKPVV AFVRLSPAVM LNGLAEVPIV
TRFLFILLGP LGKGPQYHEI GRSIATLMTD EVFHDVAYKA KDRNDLIAGI DEFLDQVTVL
PPGEWDPSIR IEPPKNVPSQ EKRKIAAQTG IDLGDEEEHE GHGGPELQRT GRLFGGLLMD
IKRKAPHYLS DYTDGLSLQC LASFLFLYCA CMSPVITFGG LLGEATEGRI SAIESLFGAS
MTGIAYSLFA GQPLTILGST GPVLVFEKIL YKFCKEYGLS YLSLRTCIGL WTAFLCLLLV
ATDASSLVCY ITRFTEEAFA SLICIIFIYE ALEKLIHLGE HYPINMNNNL DKLTRYSCSC
VEPPDPSNAT LRYWEQNNIT ASEIYWEALE VKDCIKRRGE FVGTACGPHG PYIPDVLFWS
VVLFFSTVFM SAFLKEFKFS RYFPTKLRAV ISDFAVFITI FTMVLVDYVL GVPSPKLKVP
SVFKPTRDDR GWLISPLGGN PWWTTLVTVI PALLCTILIF MDQQITAVII NRKEHKLKKG
CGYHLDLFVV GIMLGVCSIM GLPWFVAATV LSISHVNSLK LESECSAPGE QPKFLGIREQ
RFTGLMIFLL MGCSVFMTSV LKYIPMPVLY GVFLYMGASS LRGIQFFDRL KLFGMPAKHQ
PDFIYLRYVP LRKVHLFTII QLSCLVMLWV IKTSNYAIVF PMMVLALVFI RKLMDCFFTK
REMSWLDDLM PESKKKKLEE AEEEEEEQSM LGEEEGVVQL PLEGYQKSES VLNITDEMSK
GSFGNTWNVN SDNSKWYCIA SSMFPQNQHI GVFHLKRIFV SLLSVCIKNV S
//
