ID A0A060VSS0_ONCMY Unreviewed; 1007 AA.
AC A0A060VSS0;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Unconventional myosin-VI {ECO:0000256|ARBA:ARBA00015382};
DE AltName: Full=Unconventional myosin-6 {ECO:0000256|ARBA:ARBA00030027};
GN ORFNames=GSONMT00076792001 {ECO:0000313|EMBL:CDQ58008.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ58008.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ58008.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ58008.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cell projection, microvillus
CC {ECO:0000256|ARBA:ARBA00004105}. Cytoplasmic vesicle, clathrin-coated
CC vesicle {ECO:0000256|ARBA:ARBA00004132}. Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004600}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; FR904295; CDQ58008.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060VSS0; -.
DR STRING; 8022.A0A060VSS0; -.
DR PaxDb; 8022-A0A060VSS0; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:InterPro.
DR GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd21759; CBD_MYO6-like; 1.
DR CDD; cd22294; MYO6_MIU_linker; 1.
DR CDD; cd21958; MyUb_Myo6; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 6.10.220.10; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR049016; MYO6_lever.
DR InterPro; IPR032412; Myosin-VI_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF745; UNCONVENTIONAL MYOSIN-VI; 1.
DR Pfam; PF21521; MYO6_lever; 1.
DR Pfam; PF16521; Myosin-VI_CBD; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hearing {ECO:0000256|ARBA:ARBA00022740};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380}.
FT DOMAIN 1..451
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 331..353
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 655..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1007 AA; 116456 MW; 8E5C809F45D494AC CRC64;
MCGAMKKIGL DDTEKLDLFR VVAGVLHLGN IDFEETGSTS GGCILMNQSS QKLAYCADLL
GLDQEDLRVS LTTRVMLTTA GGAKGTVIKV PLRVEQANNA RDAMAKAVYS CLFDHVVRRV
NQCFPFKTSS NFIGVLDIAG FEYFEHNSFE QFCINYCNEK LQQFFNERIL KEEQELYQRE
GLGVNEVHYV DNQDCIDLVE AKLVGILDIL DEENRLPQPS DHHFANTIHS QHKDHFRLTV
PRKSKLAVHR NVRDDEGFIV RHFAGAVCYE TIQFVEKNND ALHMSLESLV CESKDKFVRE
LFENSNNSKD SKQKAGKLSF ISVGNKFKTQ LNLLLEKLRS TGSSFIRCVK PNLKMVSHQF
EGAQILSQLQ CSGMVSVLDL MQGGFPSRAP FHELYNMYKQ YMPDKLTRLD PRLFCKALFK
ALGLNENDYK FGLTRVFFRP GKFAEFDQIM KSDPDHLAEL VKKVNQWLVI SRWKKVQWCS
LSVIKLKEKM KYRASALITI QKTVRMWLCK RKHKPRIDGM VKVRNLKTRM ERFNEVVGAL
KEGKQEMAKQ IQELGASIDT LMAKIKDRVT HLSYFSDLIP QISHLCASAQ PCAPLLASAL
CSLAPGDATV MTRKEIDQEY QGLVKRSEQL LSSMQKKKQE EEEMERLRRI EEEMAQERRR
REEEDQRRQK EEDDRRMKSE MEHKRKQEEE ERKKREEEER IMQAEMDIQI ALEREEDAQR
SAMLEQEKRD RELAMRIAQS EAELITDEAL MDLSLRSAGG LQNLKAITME EMALEMSQLL
AWGPQVQALK AAGVRKYDLS KWKYAELRDV INTSCDIELL AACREEFHRR LKVYHAWKSK
NKKRDTATEQ RAPKSITDYV TTSNPPHTAQ QNPAPAVAAQ QQEIAMNRQQ RYFRIPFIHP
GDQYKDPQNK KKGWWYAHFD GPWIARQMEL HPDKQPILLV AGKDDMEMCE LSLEETGLTT
KRGAEILPRQ FEEVWERCNG IMYLRNAIES RQARPTYATA MLQNLLQ
//
