ID A0A060VX02_ONCMY Unreviewed; 2120 AA.
AC A0A060VX02;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|SMART:SM00181};
GN ORFNames=GSONMT00080078001 {ECO:0000313|EMBL:CDQ59533.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ59533.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ59533.1, ECO:0000313|Proteomes:UP000193380}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
CC -!- SIMILARITY: Belongs to the SAPS family.
CC {ECO:0000256|ARBA:ARBA00006180}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; FR904327; CDQ59533.1; -; Genomic_DNA.
DR STRING; 8022.A0A060VX02; -.
DR PaxDb; 8022-A0A060VX02; -.
DR Proteomes; UP000193380; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019903; F:protein phosphatase binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR007587; SAPS.
DR PANTHER; PTHR46513:SF16; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR Pfam; PF00058; Ldl_recept_b; 10.
DR Pfam; PF04499; SAPS; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00192; LDLa; 2.
DR SMART; SM00135; LY; 17.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 2.
DR PROSITE; PS51120; LDLRB; 11.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT REPEAT 1..42
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 43..85
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 134..173
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 221..263
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 264..306
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 307..350
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 351..393
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 440..477
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 523..565
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 566..608
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 609..651
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 652..693
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 741..778
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 961..1003
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1053..1097
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 839..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1823..2120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1848..1870
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1883..1947
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2002..2027
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2029..2043
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2044..2074
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1117..1132
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1135..1147
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1142..1160
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1154..1169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 2120 AA; 237960 MW; 19504CB1D12191BA CRC64;
MYWTDWGEEP RIERAGMDGS NRKIIVEVDI YWPNGLTIDL DEQKLYWADA KLSFIHRANL
DGSSRETVVE GTLTHPFALT LSDETLYWTD WQTRSIHACN KHTGDKRREI LSGIYSPMDI
QVLGSDRQPD IHTPCSDSNG GCSHLCLLSP VQPFYSCACP TGVKLKEDGK TCRPGAEQVL
LLARRTDLRR ISLDLPDYTD IVLQVDDIRH AIAIDYDPVD GYVYWTDDEV KAIRCSRIDG
TEAQTLVTTE INHPDGIAVD WVARNLYWTD TGTDRIEVTR LNGTSRRILI SENLDEPRAI
VLDPVNGYMY WTDWGEKPKI ERANLDGMER LVLLNTSLGW PNGLAIDYEA GKLYWGDAKT
DKIEVIDVDG SNRMTLLEDK LPHIFGFTLL GDYIYWTDWQ RRSIERVHKT NAIREIIIDQ
LPDLMGLKAT RVTEVSGTNG CVEDNGGCSH LCFHRPQGLR CDCPMGLELL SDMRTCVVPE
AFLLFTNRAD IRSISLGTNS NDVAIPLTGV KEASALDFDV SENRIYWTDV STKTISRAFM
NGSSVEHVIE FGLDYPEGMA VDWMGRNVYW ADTGTNRIEV ARLDGQYRQV LVCKDLDNPR
SLALNPANGY MYWTEWGGKP RIARAHMDGS NIITLVDKVG RANGLTIDYI DQRLYWTDLD
TCMIESTNMQ GLQREIVADD LPHPFGLTQY RDYIYWTDWN LRSIERADKR SGLNRTMVQG
HLEYVMDILV FHSSRQDGAN DCSQNNGNCA HLCLASPSGS QCRCASHYIL DSNSRNCSSP
SSFLLFSQKA SISRMVLGEQ SPDIILPIHV LRNVRAISYD PLDHLIYWVD GRQNIRRARD
DGTQSSVVVS TTSTHQQQPD KQPHDLSLDT YSRTVYWTCE ATNTINLQRL DGDAVGVVLR
DEHDKPRAIV VNAEKGYMYF TTMQDRSAKI EGASLDGTER ESLFTTGLIR PVALALDNKL
GKLFWVDADL KRIESSDLTG ANRIVLQDSN ILQPMGLTVL GEHLYWIDRQ QQMIERVDKL
IGEKRTRIQG RIAYLTSIHA VEDMDPTEFA SHPCSHDNGG CSHICIAKGD RTPRCSCPMH
LVLLPNLLIC GDPPTCSTEQ FTCATGDIDC IPMAWRCDGV AECDDNSDEE NCPVCSAIQF
QCDKGQCVDA QLRCNGEPDC ADNSDEQDCD KHKHYFIFNL WTDSTPVRSI MFWKFDLHTT
SHIDTLLEKE DVTLTEVMDE EDVLQECKAQ NHKLVDFLVR PQCMVDLVTY ITQEPSDDVE
EKIKYKYPNI SCELLTSDVG QINDRLGEDE SLLMKLYGFL QRDSPLNPLL ASFFSKVLSI
LIGRKPEQIV EFLRKREDFV DLMIKHIGTS AIMDLLLRML TCIEPQQLRQ DVLNWLNEEK
VIQRLVDMVQ PSQDEDRHSN ASQSLCEIIR LSRDQMFQVQ GCSEPDPLLA TLEKQETVEQ
LLSNIFDKEK NDSAIVSVIQ ILLTLFETRR PAFEGHLEIC PPGMSHPSFS VNQSILEAVR
PRLKDFHQLL LEPPKKNIMK TTWGMLDPPV GNTRLSVVRL VASLLQTNTH IINMELINLN
TLGVILDMYF NYIWNNFLHI QVEICTAMIL AMPPAQSENP EINRDQDQEP VRESHLIKHL
FQKCQFIQRI LDAWSSNEKE QGEGGRRRGY MGHLTRIANS IVHNSDKGPN GAKIQQLISE
LTEDDKERWE AFTSGQLADT NKRNTVDLVN THHIHSSSDD EVDFKDSGFH QDSSLQQAFS
DYQMQQMTSN FIEQFGFNDE EFADQDDVVD IPFDRISDIN FSLNTNESAN IALFEACCKE
KIQQFEDAGS DEEDIWDEKD ITFAPEAQRC PRSSGSTDSE ESTDSEEEDV KRDPFEPNNA
SSDDRMEVDT GEGPVWTANF DDIPMDTGSS TSIRAPGLAT TTATASPSSP AVLPESAGWS
SPNASPDTAT GWADFSSNFS PVNPKDPLRN NSPVAMETCI GTGDPLGVNA PLQPEVSDQW
PGDEAAQPAS SPGRKAGGSD AEETITTETV TNGSMKETVS LTVDAKTETA VFKSEDEKST
SEDTSAKYTV GESRTPEKGV SASVQPASNC LKPSAKHSDT EKSKVSSDAV NGPLEEGTAM
DKAKTQQSVT SPEAAVNGPV
//