GenomeNet

Database: UniProt
Entry: A0A060VX02_ONCMY
LinkDB: A0A060VX02_ONCMY
Original site: A0A060VX02_ONCMY 
ID   A0A060VX02_ONCMY        Unreviewed;      2120 AA.
AC   A0A060VX02;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   RecName: Full=EGF-like domain-containing protein {ECO:0000259|SMART:SM00181};
GN   ORFNames=GSONMT00080078001 {ECO:0000313|EMBL:CDQ59533.1};
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ59533.1, ECO:0000313|Proteomes:UP000193380};
RN   [1] {ECO:0000313|EMBL:CDQ59533.1, ECO:0000313|Proteomes:UP000193380}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24755649; DOI=10.1038/ncomms4657;
RA   Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA   Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA   Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA   Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA   Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA   Guiguen Y.;
RT   "The rainbow trout genome provides novel insights into evolution after
RT   whole-genome duplication in vertebrates.";
RL   Nat. Commun. 5:3657-3657(2014).
CC   -!- SIMILARITY: Belongs to the SAPS family.
CC       {ECO:0000256|ARBA:ARBA00006180}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FR904327; CDQ59533.1; -; Genomic_DNA.
DR   STRING; 8022.A0A060VX02; -.
DR   PaxDb; 8022-A0A060VX02; -.
DR   Proteomes; UP000193380; Chromosome 1.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019903; F:protein phosphatase binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR   CDD; cd00112; LDLa; 2.
DR   Gene3D; 2.10.25.10; Laminin; 1.
DR   Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR007587; SAPS.
DR   PANTHER; PTHR46513:SF16; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5; 1.
DR   PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR   Pfam; PF14670; FXa_inhibition; 3.
DR   Pfam; PF00057; Ldl_recept_a; 2.
DR   Pfam; PF00058; Ldl_recept_b; 10.
DR   Pfam; PF04499; SAPS; 2.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00181; EGF; 4.
DR   SMART; SM00192; LDLa; 2.
DR   SMART; SM00135; LY; 17.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 1.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   SUPFAM; SSF57424; LDL receptor-like module; 2.
DR   SUPFAM; SSF63825; YWTD domain; 4.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 2.
DR   PROSITE; PS51120; LDLRB; 11.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW   Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT   REPEAT          1..42
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          43..85
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   DOMAIN          134..173
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|SMART:SM00181"
FT   REPEAT          221..263
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          264..306
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          307..350
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          351..393
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   DOMAIN          440..477
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|SMART:SM00181"
FT   REPEAT          523..565
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          566..608
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          609..651
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          652..693
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   DOMAIN          741..778
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|SMART:SM00181"
FT   REPEAT          961..1003
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   DOMAIN          1053..1097
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|SMART:SM00181"
FT   REGION          839..865
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1823..2120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        840..865
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1848..1870
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1883..1947
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2002..2027
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2029..2043
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2044..2074
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        1117..1132
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1135..1147
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1142..1160
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1154..1169
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ   SEQUENCE   2120 AA;  237960 MW;  19504CB1D12191BA CRC64;
     MYWTDWGEEP RIERAGMDGS NRKIIVEVDI YWPNGLTIDL DEQKLYWADA KLSFIHRANL
     DGSSRETVVE GTLTHPFALT LSDETLYWTD WQTRSIHACN KHTGDKRREI LSGIYSPMDI
     QVLGSDRQPD IHTPCSDSNG GCSHLCLLSP VQPFYSCACP TGVKLKEDGK TCRPGAEQVL
     LLARRTDLRR ISLDLPDYTD IVLQVDDIRH AIAIDYDPVD GYVYWTDDEV KAIRCSRIDG
     TEAQTLVTTE INHPDGIAVD WVARNLYWTD TGTDRIEVTR LNGTSRRILI SENLDEPRAI
     VLDPVNGYMY WTDWGEKPKI ERANLDGMER LVLLNTSLGW PNGLAIDYEA GKLYWGDAKT
     DKIEVIDVDG SNRMTLLEDK LPHIFGFTLL GDYIYWTDWQ RRSIERVHKT NAIREIIIDQ
     LPDLMGLKAT RVTEVSGTNG CVEDNGGCSH LCFHRPQGLR CDCPMGLELL SDMRTCVVPE
     AFLLFTNRAD IRSISLGTNS NDVAIPLTGV KEASALDFDV SENRIYWTDV STKTISRAFM
     NGSSVEHVIE FGLDYPEGMA VDWMGRNVYW ADTGTNRIEV ARLDGQYRQV LVCKDLDNPR
     SLALNPANGY MYWTEWGGKP RIARAHMDGS NIITLVDKVG RANGLTIDYI DQRLYWTDLD
     TCMIESTNMQ GLQREIVADD LPHPFGLTQY RDYIYWTDWN LRSIERADKR SGLNRTMVQG
     HLEYVMDILV FHSSRQDGAN DCSQNNGNCA HLCLASPSGS QCRCASHYIL DSNSRNCSSP
     SSFLLFSQKA SISRMVLGEQ SPDIILPIHV LRNVRAISYD PLDHLIYWVD GRQNIRRARD
     DGTQSSVVVS TTSTHQQQPD KQPHDLSLDT YSRTVYWTCE ATNTINLQRL DGDAVGVVLR
     DEHDKPRAIV VNAEKGYMYF TTMQDRSAKI EGASLDGTER ESLFTTGLIR PVALALDNKL
     GKLFWVDADL KRIESSDLTG ANRIVLQDSN ILQPMGLTVL GEHLYWIDRQ QQMIERVDKL
     IGEKRTRIQG RIAYLTSIHA VEDMDPTEFA SHPCSHDNGG CSHICIAKGD RTPRCSCPMH
     LVLLPNLLIC GDPPTCSTEQ FTCATGDIDC IPMAWRCDGV AECDDNSDEE NCPVCSAIQF
     QCDKGQCVDA QLRCNGEPDC ADNSDEQDCD KHKHYFIFNL WTDSTPVRSI MFWKFDLHTT
     SHIDTLLEKE DVTLTEVMDE EDVLQECKAQ NHKLVDFLVR PQCMVDLVTY ITQEPSDDVE
     EKIKYKYPNI SCELLTSDVG QINDRLGEDE SLLMKLYGFL QRDSPLNPLL ASFFSKVLSI
     LIGRKPEQIV EFLRKREDFV DLMIKHIGTS AIMDLLLRML TCIEPQQLRQ DVLNWLNEEK
     VIQRLVDMVQ PSQDEDRHSN ASQSLCEIIR LSRDQMFQVQ GCSEPDPLLA TLEKQETVEQ
     LLSNIFDKEK NDSAIVSVIQ ILLTLFETRR PAFEGHLEIC PPGMSHPSFS VNQSILEAVR
     PRLKDFHQLL LEPPKKNIMK TTWGMLDPPV GNTRLSVVRL VASLLQTNTH IINMELINLN
     TLGVILDMYF NYIWNNFLHI QVEICTAMIL AMPPAQSENP EINRDQDQEP VRESHLIKHL
     FQKCQFIQRI LDAWSSNEKE QGEGGRRRGY MGHLTRIANS IVHNSDKGPN GAKIQQLISE
     LTEDDKERWE AFTSGQLADT NKRNTVDLVN THHIHSSSDD EVDFKDSGFH QDSSLQQAFS
     DYQMQQMTSN FIEQFGFNDE EFADQDDVVD IPFDRISDIN FSLNTNESAN IALFEACCKE
     KIQQFEDAGS DEEDIWDEKD ITFAPEAQRC PRSSGSTDSE ESTDSEEEDV KRDPFEPNNA
     SSDDRMEVDT GEGPVWTANF DDIPMDTGSS TSIRAPGLAT TTATASPSSP AVLPESAGWS
     SPNASPDTAT GWADFSSNFS PVNPKDPLRN NSPVAMETCI GTGDPLGVNA PLQPEVSDQW
     PGDEAAQPAS SPGRKAGGSD AEETITTETV TNGSMKETVS LTVDAKTETA VFKSEDEKST
     SEDTSAKYTV GESRTPEKGV SASVQPASNC LKPSAKHSDT EKSKVSSDAV NGPLEEGTAM
     DKAKTQQSVT SPEAAVNGPV
//
DBGET integrated database retrieval system