ID   A0A060VZC2_ONCMY        Unreviewed;       340 AA.
AC   A0A060VZC2;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=glutaminyl-peptide cyclotransferase {ECO:0000256|ARBA:ARBA00012012};
DE            EC=2.3.2.5 {ECO:0000256|ARBA:ARBA00012012};
GN   ORFNames=GSONMT00081163001 {ECO:0000313|EMBL:CDQ60141.1};
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ60141.1, ECO:0000313|Proteomes:UP000193380};
RN   [1] {ECO:0000313|EMBL:CDQ60141.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24755649; DOI=10.1038/ncomms4657;
RA   Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA   Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA   Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA   Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA   Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA   Guiguen Y.;
RT   "The rainbow trout genome provides novel insights into evolution after
RT   whole-genome duplication in vertebrates.";
RL   Nat. Commun. 5:3657-3657(2014).
RN   [2] {ECO:0000313|EMBL:CDQ60141.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Genoscope - CEA;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-
CC         [peptide] + NH4(+); Xref=Rhea:RHEA:23652, Rhea:RHEA-COMP:11736,
CC         Rhea:RHEA-COMP:11846, ChEBI:CHEBI:28938, ChEBI:CHEBI:64722,
CC         ChEBI:CHEBI:87215; EC=2.3.2.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00000001};
CC   -!- SIMILARITY: Belongs to the glutaminyl-peptide cyclotransferase family.
CC       {ECO:0000256|ARBA:ARBA00006014}.
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DR   EMBL; FR904341; CDQ60141.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A060VZC2; -.
DR   STRING; 8022.A0A060VZC2; -.
DR   PaxDb; 8022-A0A060VZC2; -.
DR   Proteomes; UP000193380; Unassembled WGS sequence.
DR   GO; GO:0016603; F:glutaminyl-peptide cyclotransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd03880; M28_QC_like; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR037457; M28_QC.
DR   InterPro; IPR007484; Peptidase_M28.
DR   InterPro; IPR040234; QC/QCL.
DR   PANTHER; PTHR12283; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE; 1.
DR   PANTHER; PTHR12283:SF3; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-LIKE PROTEIN; 1.
DR   Pfam; PF04389; Peptidase_M28; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          98..331
FT                   /note="Peptidase M28"
FT                   /evidence="ECO:0000259|Pfam:PF04389"
SQ   SEQUENCE   340 AA;  38432 MW;  C3976056F0C87BF9 CRC64;
     MHDNIQFRVP DLIRDKLTHN PRRSTVAQIK RLVGQVNSGR LWYSLLRPIL VERLPGTRGS
     RRVREHIYSH LEFLSAGWSL EVDSFNSATP KGLITFSNLL AVLDPSAPRR LLLACHYDSK
     AMPPASKTPD GPLRRFLGAS DAAVPCAMIL ELVTALDVHL KVLKQQKSQV TLQLVFFDGN
     EAFEQPSPSD SLYGSRYLAE QMSRTPHPPG AEHTTLLNAL DLFVLLDLIG APDPMFVNHF
     DNTVRWFDEL IYAERRLHKL GLLSSHPREV SYFRKDINLG PVEDDHVPFL QQGVPVLHMI
     TTPFPSFMHT LEDTAEHIHS QTIENLTKVL VVFLAEYIGL
//