ID A0A060VZK5_ONCMY Unreviewed; 739 AA.
AC A0A060VZK5;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=UDP-N-acetylglucosamine 2-epimerase domain-containing protein {ECO:0000259|Pfam:PF02350};
GN ORFNames=GSONMT00074052001 {ECO:0000313|EMBL:CDQ57720.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ57720.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ57720.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ57720.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FR904290; CDQ57720.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060VZK5; -.
DR STRING; 8022.A0A060VZK5; -.
DR PaxDb; 8022-A0A060VZK5; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0006047; P:UDP-N-acetylglucosamine metabolic process; IEA:InterPro.
DR CDD; cd03786; GTB_UDP-GlcNAc_2-Epimerase; 1.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000600; ROK.
DR InterPro; IPR020004; UDP-GlcNAc_Epase.
DR InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR NCBIfam; TIGR03568; NeuC_NnaA; 1.
DR PANTHER; PTHR18964:SF149; BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE_N-ACETYLMANNOSAMINE KINASE; 1.
DR PANTHER; PTHR18964; ROK (REPRESSOR, ORF, KINASE) FAMILY; 1.
DR Pfam; PF02350; Epimerase_2; 1.
DR Pfam; PF00480; ROK; 1.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000193380}.
FT DOMAIN 47..389
FT /note="UDP-N-acetylglucosamine 2-epimerase"
FT /evidence="ECO:0000259|Pfam:PF02350"
FT ACT_SITE 533
FT /evidence="ECO:0000256|PIRSR:PIRSR620004-1"
FT BINDING 585
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="structural"
FT /evidence="ECO:0000256|PIRSR:PIRSR620004-3"
FT BINDING 595
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="structural"
FT /evidence="ECO:0000256|PIRSR:PIRSR620004-3"
FT BINDING 597
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="structural"
FT /evidence="ECO:0000256|PIRSR:PIRSR620004-3"
FT BINDING 602
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="structural"
FT /evidence="ECO:0000256|PIRSR:PIRSR620004-3"
SQ SEQUENCE 739 AA; 81147 MW; E1C65631886BB430 CRC64;
MQRTREKPDK LEESKAMRKL RVCVATCNRA DYSKLAPIMF GIKANPDEFE LEVVVLGSHL
IDDYGNTFRM IEQDDFDIGS KLHTIVRGED EAAMVESVGL ALVKLPDVLH RLRPDVLVVH
GDRFDALALA TAAALMNIRI LHLEGGEVSG TIDDSIRHAI SKLAHYHACC TRTAEQHLIA
MCEDHTRILL AGCPSYDKLL AAHHRDDYMD IIRNWLGDNV KEHDYIVALQ HPVTTDIKNS
VKIYELMLDA LISFNKRTLV LFPNIDAGSK EMVRVMRKKG VEQHPNFRAV KHVPFEQFIQ
LVCHAGAMIG NSSCGVREAG AFGTPVINLG SRQTGRETGE NVLHVRDADT QNKIYHALEL
QFGKRYPWLA LSSSIYGDGN AVPRIMKFLQ AIDLDEPLQK TFCFPPIREW DISQDIDHIL
ETQGALAIDL GGTNLRVAIV SMRGKIVKKY SQGNPKTYEA RIELILKMCA EAVFDAVHLN
CRILGVGVST GGRVNPQEGV ILHSTKLIQE WSSIDIRTPI SDALHLPVWV DNDGNCAALA
EKKFGHGKGV ENFVTIITGT GIGGGIIQHN ELIHGSTFCA AELGHIMVSL DGPECMCGSR
GCIEAYASGM ALQKEAKRLH DEELLEVEGM VDLKKAESVG AIHLINAARL GNSKAGAVLR
TAGMALGVGI VNILHVVNPS LVILSGVLAA HYQAPVQQVI GQRALTSAQR IQVLTSDLEE
PALLGAASMV LDYTTRRIY
//
