ID A0A060W442_ONCMY Unreviewed; 250 AA.
AC A0A060W442;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Troponin I, fast skeletal muscle {ECO:0000256|ARBA:ARBA00039349};
DE AltName: Full=Troponin I, fast-twitch isoform {ECO:0000256|ARBA:ARBA00042462};
GN Name=TNNT3 {ECO:0000313|Ensembl:ENSOMYP00000030401.1};
GN ORFNames=GSONMT00065899001 {ECO:0000313|EMBL:CDQ61776.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ61776.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ61776.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ61776.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSOMYP00000030401.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin
CC filament regulatory complex which confers calcium-sensitivity to
CC striated muscle actomyosin ATPase activity.
CC {ECO:0000256|ARBA:ARBA00001988}.
CC -!- SUBUNIT: Binds to actin and tropomyosin.
CC {ECO:0000256|ARBA:ARBA00038767}.
CC -!- SIMILARITY: Belongs to the troponin I family.
CC {ECO:0000256|ARBA:ARBA00009930}.
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DR EMBL; FR904389; CDQ61776.1; -; Genomic_DNA.
DR STRING; 8022.A0A060W442; -.
DR PaxDb; 8022-A0A060W442; -.
DR Ensembl; ENSOMYT00000033143.2; ENSOMYP00000030401.1; ENSOMYG00000014129.2.
DR GeneTree; ENSGT00940000158477; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR Proteomes; UP000694395; Chromosome 2.
DR GO; GO:0005861; C:troponin complex; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.350; -; 1.
DR Gene3D; 6.10.250.180; -; 1.
DR InterPro; IPR001978; Troponin.
DR InterPro; IPR038077; Troponin_sf.
DR PANTHER; PTHR13738; TROPONIN I; 1.
DR PANTHER; PTHR13738:SF15; TROPONIN I, FAST SKELETAL MUSCLE; 1.
DR Pfam; PF00992; Troponin; 1.
DR SUPFAM; SSF90250; Troponin coil-coiled subunits; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380}.
FT COILED 99..150
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 250 AA; 28759 MW; 58D8DF3BE544C4E4 CRC64;
MEVRLWLEFQ QLAEPLVWSG TPFQFHKEKC RVLLTHHRNP LKPPEHFSCL SQSQACVLLD
RQLSLIDPFG KLQESKMSEK KMSSSRKHHL KSVMLQIAKD LLEAEAIEAV EEKKRYMDET
CPALDLPGSL VELQEMCKTI HHQLDKVDEE RYDLAGKVGK CDKEIDDLRI KVVEIQGIKK
PALKKVRMSA DAMLQALLGS KHKVTMDLRS NLKQVKKEVK EDDKDTVGDW RKNIDDKAGM
DGRKKMFEAA
//
