ID A0A060WA10_ONCMY Unreviewed; 1343 AA.
AC A0A060WA10;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CDQ62084.1};
GN ORFNames=GSONMT00066406001 {ECO:0000313|EMBL:CDQ62084.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ62084.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ62084.1, ECO:0000313|Proteomes:UP000193380}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; FR904396; CDQ62084.1; -; Genomic_DNA.
DR STRING; 8022.A0A060WA10; -.
DR PaxDb; 8022-A0A060WA10; -.
DR Proteomes; UP000193380; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0030301; P:cholesterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF3; NPC1-LIKE INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
SQ SEQUENCE 1343 AA; 148103 MW; 359FD7015DAD830D CRC64;
MGRPTMSRAT ALLTLLACLV VLEARHEPGY CAFYEECGRN PTVAGSLLPP IIPCLNYSRA
RALEGEHYQQ LKKVCPMLDR GEGSTTACCS IKQLKSLEMS LMLSKAVLMR CPSCADNFAH
LHCINTCSPD QTTTINVTRT MNITTLGIVK EAVVGYQAYL STSFADKSFE SCKNVRIPAT
GGYAIATMCG RYGSALCTAQ RWYDFQGDSS NGLAPLDIDF RLIPEGVTEG IPDGVVPYAG
RALGCNEMTP TGAEVCSCQD CQASCPVVPS PPPPAEPFTI GGVDGYLVLC VIFLCVLILA
FLLFVLSTYL LRKEEGKDSE KGKGKGKGMD KNGNNVSERL IEPWEVTCTD KNSLATQEFL
GSGFRAWGTL VASHPLKVLL ASAVVTAAFA TGLMHIELTT DPVQLWSAPN SRARMEKDFH
DKHFDPFFRT NQMILTAPGR PGHFYDSLLF GKQNFSGIIA KDLILELLKL QKKIQNIEFW
SNDLNRMASL KDVCFAPLNP SNPSLTDCAV NSLPQYFQNS VDNLNAKVNM TELGVTKEVD
WRDHFIYCVN SPLSFKDITD LQLSCMADYG APVFPFLAVG GYENEGYTTA EALILTFSLN
NYPRDNVKFK VALEWEQRFL DIVQEYQKSP GNPFTFAYMA ERSLEDEINR TTAEDIPIFM
ISYAVIFVYI AVALGEYTSF SRILVDSKFL VGLGGILVVG CSVLASMGFY AWIGIPSSLI
ILQVVPFLVL AVGADNIFIF VLEYQRDARR PGEKREERIG RVLGNVAPSM LLCSLSESVC
FFLGALSTMP AVKSFALYAA LAVLMDFVLQ MTAFVALLSL DARRQDGNRC ELACCVSVKT
TAPSKPNEGF LLPAMRKYYA PVLLHPVTRV IVIVVFIFMF ISSIYLMFYV TVGLDQELAM
PQGSYMLEYF KYLYAYFEVG VPTYFVTTKG FNFTSIAGMN ATCSSVGCDP FSLTQKIQYA
TEYPDLSYMA IPANSWVDDF IDWLNPGSKC CRLYSIGPNK GKFCPASESA FLCGQKCMKT
PLNGVLRPDK EQFNRFLPDF LGNRPDLQCP KGGLGAYDKA VITDESGEII ATRFMAYHTA
LTTSKEFTAA LKIARELAHN ITLSMRSIPG TSQDFEVFPY TVTYVFYEQY LTIVSEGLFN
ISLCLLPTFV VCCLLLGMDL RSGVLNLLTI IMITVDTVGV MTLWGIDYNA VALINLVTAV
GISVEFVSHM TRSFAMSIQP THVERAKEAT ATMGSAVFAG VAMTNLPGIV VLAFAKAQLI
QIFFFRLNLV ITLLGMAHGL IFLPVLLSYF GPGVNKAVLL RLQQAKAQEL ELSSNAKNIY
DNIGYENQEN SPNPHHPVRT PHH
//
