ID A0A060WEI8_ONCMY Unreviewed; 488 AA.
AC A0A060WEI8;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0000259|PROSITE:PS50009};
GN ORFNames=GSONMT00073529001 {ECO:0000313|EMBL:CDQ65572.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ65572.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ65572.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ65572.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FR904512; CDQ65572.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060WEI8; -.
DR STRING; 8022.A0A060WEI8; -.
DR PaxDb; 8022-A0A060WEI8; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF230; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR-LIKE 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380}.
FT DOMAIN 250..486
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 488 AA; 56431 MW; 8D5661C3A82D3665 CRC64;
MLTHPIFLAS DRFQQVLLQQ FGVEGKAGEG WPSWDGAERK QAVLSVAFRY LDTYRELLQE
EGERSNSFPK ELYLCAVQQL SQFPELVEDV LKLQRWTEIL QCPSSEEDKE IRKKQVRPLF
RHFRRIDACL QPREAFRGSD EIFCRVYTPD HSYVTIRSRL SCRVGEILAL VREKLQYSED
QPTQPGNLLL VAVTSAGEKA AFRPSDEAVF TTLGVNTHLF ACEPSELESL LPLPEEIHWS
PGDSKLHDMS AEEVATQLVV FDWELFSCVH EVEFVCYVFH GEQARWRPLN LELVLQRCSE
VQHWVATEIL QCQSLPKRVQ LLRKFIKIAA LCKQQQDLLS FLAVVLGLDN PAVSRLRLTW
EGLPGKFRKQ FQQFESIADP SRNHKSYRDL MGSLRPPLIP FTPLLLKDLT FLHESCKSFH
GELVNFEKMH KVAEMVRSIR RYRSSQLALD AEPSPSHLQT KAYVRQLQVI DNQNLLFEMS
CKLEPKDM
//
