ID   A0A060WEQ0_ONCMY        Unreviewed;       864 AA.
AC   A0A060WEQ0;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   08-NOV-2023, entry version 41.
DE   RecName: Full=RAS protein activator like 1 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=GSONMT00073645001 {ECO:0000313|EMBL:CDQ65637.1};
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ65637.1, ECO:0000313|Proteomes:UP000193380};
RN   [1] {ECO:0000313|EMBL:CDQ65637.1, ECO:0000313|Proteomes:UP000193380}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24755649; DOI=10.1038/ncomms4657;
RA   Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA   Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA   Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA   Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA   Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA   Guiguen Y.;
RT   "The rainbow trout genome provides novel insights into evolution after
RT   whole-genome duplication in vertebrates.";
RL   Nat. Commun. 5:3657-3657(2014).
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DR   EMBL; FR904513; CDQ65637.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A060WEQ0; -.
DR   STRING; 8022.A0A060WEQ0; -.
DR   PaxDb; 8022-A0A060WEQ0; -.
DR   Proteomes; UP000193380; Chromosome 6.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0071277; P:cellular response to calcium ion; IEA:InterPro.
DR   GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR   CDD; cd05135; RasGAP_RASAL; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR037776; RASAL_RasGAP.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   PANTHER; PTHR10194:SF3; RASGAP-ACTIVATING-LIKE PROTEIN 1; 1.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF00616; RasGAP; 1.
DR   SMART; SM00239; C2; 2.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000193380}.
FT   DOMAIN          1..105
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          116..261
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          331..541
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
SQ   SEQUENCE   864 AA;  97307 MW;  50F29EF91B58D9DD CRC64;
     MAKNTSLYFR IVEGRSLPVK DVSGTSDPYC IVKVDNEVVA RTATVWKNLN PFWGEEYTLH
     LPTGFHSLSF YVMDEDTIGH DDIIGKISLS KDTIGAKVKG LDNWLNLTRV DPDEEVQGEI
     HFGLELLRDA KGIGLRCHFI EARGREVPER ASVRGWRLST VSMAAIHLGY LAPRDISGTS
     DPFARILFNN HSAETSIIKK TRYPHWGETL ELELETEELS EGGTVTVEVW DWDMVGKNDF
     LGKVEIPFAC LHKTPLVQGW FRLMPLGNNE DDAGGKLGAL RLKVRLVEDH ILPSMYYQPL
     IDLLVQSVIS PAEVEDGSPL TMLEEVTTVE SRQDVAMTLV KIYLGRGLVV PFLDYLNTRE
     VNHTLDPNTL FRSNSLASKA MEQFMKAVGM LYLHEVLKPI INRIFEEKKY IELDPCKIDL
     NRTRRISFKG AVSEAEVRES SVEMLQGYLS NIVESIIGSV TQCPPVMRVA FKQLHKRVEE
     QFPESENEDV KYLAISGFFF LRFLAPAILT PKLFHLRDQH ADTRTSRTLL LLAKAVQSVG
     NLGLQLGHGK ELWMEPLHPI ILYSVASVKD FLDKLIDIDS VSEVPQRAVF LPSVTVKEGY
     LQKHKAESPQ LLSRFSFKKR YFWLSSETLS YAKTPDPWQK DAAVIPIFKG GDTLEPNCYR
     PISILPCLSK IFESQVNKQI TNHLESHRTI STIQSDSISL VSQMTASPGS STTSQIDSIS
     FVTKAPYTTH HCDLYAVVGW PSLHIHRQTH WHQVIYKSLL ASGCSRTHSA VTLGDWSDPL
     DPDAETQTIY KQLLQGRDKL RDCQSSAFLI CSSISFNTLA VRELLKHRQA AAVRLLGVVL
     DLEQAHATFQ RQERVEAGSL ILTP
//