ID A0A060WIB8_ONCMY Unreviewed; 524 AA.
AC A0A060WIB8;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Growth factor receptor-bound protein 7 {ECO:0008006|Google:ProtNLM};
GN ORFNames=GSONMT00076835001 {ECO:0000313|EMBL:CDQ67048.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ67048.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ67048.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ67048.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GRB7/10/14 family.
CC {ECO:0000256|ARBA:ARBA00006708}.
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DR EMBL; FR904570; CDQ67048.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060WIB8; -.
DR STRING; 8022.A0A060WIB8; -.
DR PaxDb; 8022-A0A060WIB8; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR CDD; cd09944; SH2_Grb7_family; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR015042; BPS-dom.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR PANTHER; PTHR11243:SF25; GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7; 1.
DR Pfam; PF08947; BPS; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 96..182
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 224..333
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 423..519
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 59317 MW; 5443F5C3294D6876 CRC64;
MEVQGQWAEV FEGSDRQEDS GGESELLGSS TITLAPLVVN TPPPPVRRSQ PLVIRRSRMN
SVELSSVPSI PNPFPELCSP SQSPVLIGSL SPPRSDTHLI KVFGEDSHSR SLWVIPRATA
RDVCHLLVQT AHCSDQENWA LIELHSALGL ERVLEDHEVV VEVQAAWPSV SDTKLLFRKN
YAKYEFFRTP VLFFPKHMIS DSADVTKGMT SAELIQNLLQ SGTCPEIQGF LHVREPSRKA
WKKVYFFLRR SGLYCSTKGS SKEPRHLQYV ADLEDLNVYS ITNSRKLYGA PVDFTFCVKP
SKDRIRAQDL KLLCAENELT RTCWTSAFRL FKYGRQLHCN YQLSQSAPRL QEVVSQRCES
EASLVAMDFS GKAGGRVIQN AWEAQSAERE EGQAWRRREA LRCSLPNLNP GSQPSSIHRT
QLWFHGGVSR KQAQRLIEEQ GLVDGMFLIR ESQQHAQCFV LSLCYKLKTK HYLVIPCEEG
GRKYYTMDDG LTLFIDLLQL VEFHQINRGI LPVCLKHPCV CVAL
//
