ID A0A060WIK3_ONCMY Unreviewed; 420 AA.
AC A0A060WIK3;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=von Willebrand factor A domain-containing protein 1 {ECO:0000256|ARBA:ARBA00029542};
GN ORFNames=GSONMT00076093001 {ECO:0000313|EMBL:CDQ66801.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ66801.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ66801.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ66801.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
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DR EMBL; FR904557; CDQ66801.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060WIK3; -.
DR STRING; 8022.A0A060WIK3; -.
DR PaxDb; 8022-A0A060WIK3; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF77; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..420
FT /note="von Willebrand factor A domain-containing protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001594893"
FT DOMAIN 36..211
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 216..319
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 322..411
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 420 AA; 45467 MW; CBD8E8013DBC65C5 CRC64;
MMGWFGFSCL LFGVLLRPSN TQNVVPDAAL NCCEGDILLL LDSSGSVSSY EFSRLLRFLS
ELLLPFSLGQ GQVRVGLLQV GTEPHLEFGL DAHSTQPGLQ GALQRTRQLQ GDTNTESALI
LAQGLLARTG VGDETKLPKV LVWLTDGVEP GVVDVPMAEL RTAGVSVLAV STGHGNYQVL
RRVVTAPIES HLYFVDIDDI SIITEDLREA IIELIRAEGL RVVEVSSHSA VLQWRPVLSA
NTGFYEVHYN SMLPGGGKGQ PSGGASSGVQ YHRRTLPGDA SWIKLSGLQP DTSYTASLTP
KSNQDYLNTL SANFTTLPEV LSPAVVTVSD SGPDRVRVSW GPLQPEQVQR YQIEYGALPS
GQVHMVMLHG HQNTTLLTGL EQETQYLVTI SALYSTGKEK ALSVKACTQE GKMCVFLFTL
//
