ID A0A060WJ46_ONCMY Unreviewed; 614 AA.
AC A0A060WJ46; A0A8C7W836;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Rho GTPase activating protein 28 {ECO:0000313|Ensembl:ENSOMYP00000080913.2};
GN Name=ARHGAP28 {ECO:0000313|Ensembl:ENSOMYP00000080913.2};
GN ORFNames=GSONMT00046323001 {ECO:0000313|EMBL:CDQ67202.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ67202.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ67202.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ67202.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSOMYP00000080913.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; FR904576; CDQ67202.1; -; Genomic_DNA.
DR STRING; 8022.A0A060WJ46; -.
DR PaxDb; 8022-A0A060WJ46; -.
DR Ensembl; ENSOMYT00000088173.2; ENSOMYP00000080913.2; ENSOMYG00000037402.2.
DR GeneTree; ENSGT00940000158929; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR Proteomes; UP000694395; Chromosome 15.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04391; RhoGAP_ARHGAP18; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF5; RHO GTPASE-ACTIVATING PROTEIN 28; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380}.
FT DOMAIN 279..475
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 614 AA; 69698 MW; FDE2BD1B44B6F272 CRC64;
MSSRGARPSS PPSSLERPAS QDSMEDYWSE VKNIEEDGEQ VHEDLLERGS MDEAELEEAW
LQEAGLSTLV SGELGEGPAE ALLSTLTRSQ AAMVKKRVDN YTLTMRKRNK QPARHVQDVF
STPDTLLVDP IPPVSPKSPN GHMASRCIHR TSSRVRPAFP SFSPVERRVS ECPPSQDTSD
TLSFEVPYSE GVTAHRRGRQ GDCQDCQRIR RDDPDLPTFQ LPRPKLGLTH IQDLSCADMK
KIGYISLIEL TTFYDCLGIE LKRNRAARSK ARESGIFGVP LTTLLENDQK KFPGSKVPLV
FRKLLSKLEQ TGLQTEGILR VPGSASRVKH LRQELEQKFY EERFDWEQVR HNDAAGLLKM
FIRELPYPLL TLQHLPAFAA AQSVSSPRHQ IQALHLLIML LPEPNRDTLK ALLEFLRKVV
AYEEKNRMSL WNVSMIVAPN LFTYRGKNAK QEEMQAAAGA AHLVRLLITY QELLWTVPCF
LISHVRKLNE ASKKPPSSEK TKRKLLMMRK RNAEKTERSE LTDLREGVIR VHAPLQAKIS
MAIQLDNETK AKDVMARFDY ENGRGTRSTS QRPVQYLFEV GGNIGERCLD PETHLLDVYH
VNPHCEWLLK PTTT
//
