ID A0A060WKG9_ONCMY Unreviewed; 1054 AA.
AC A0A060WKG9;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 08-NOV-2023, entry version 35.
DE RecName: Full=I/LWEQ domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=GSONMT00028457001 {ECO:0000313|EMBL:CDQ67667.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ67667.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ67667.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ67667.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the SLA2 family.
CC {ECO:0000256|ARBA:ARBA00010135}.
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DR EMBL; FR904592; CDQ67667.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060WKG9; -.
DR STRING; 8022.A0A060WKG9; -.
DR PaxDb; 8022-A0A060WKG9; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 6.10.250.920; -; 1.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR032422; HIP1_clath-bd.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR030224; Sla2_fam.
DR PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR10407:SF14; HUNTINGTIN-INTERACTING PROTEIN 1; 1.
DR Pfam; PF07651; ANTH; 1.
DR Pfam; PF16515; HIP1_clath_bdg; 1.
DR Pfam; PF01608; I_LWEQ; 1.
DR SMART; SM00273; ENTH; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF109885; I/LWEQ domain; 1.
DR PROSITE; PS50942; ENTH; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380}.
FT DOMAIN 32..159
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT DOMAIN 795..1036
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT REGION 510..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 373..477
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1054 AA; 117270 MW; 99CB15087539C488 CRC64;
MDRVKSSMQQ VPNPIHKALI RRTGGANSFE LEKENFERGQ AVSINKAINT QEVAVKEKHA
RNILLVESGK GAHTFWAAVN RLPLSSNAVL CWKFCHVFHK LLRDGHPNVI KDSMRNKADL
SDMSRMWGHL SEGYGKLCSI YLKLLITKME FHVKNPRFPG NLQMSNRQLD EAGENDVNNF
FQLTVEMLDY LECELNLFLG VFSSLDMSRS VSVTAAGQCR LAPLIQVILD SSHLYDYTVK
LLFKLHSCLP ADTLQGHRDR FQEQFKKLKS LFYRSSNLQY FKRLIQIPQL PENPPNFLRA
SALSEHISPV VVIPAESSSP ETEHMVDLVT EDLVDTDIPV QPAAVVEPRF DDLFGTSAAT
DPFNFNSQNG MRKDDKDRLI EQLTREIQAL REELESFRLE SGRLRQALRG RVDELEAELA
EQSHLRMQAL GEGEFLRAEL DDLRRVKEDT EKEQRSLTEI ERKAVANEQR YVKLKEKYTE
LVQSHADLLR KNAEVTRQMT VARAVEDEMD SVRREMHEKV KAAKEAAERR EQEQVEQLQE
LQRELISSRA ALDTLKSSMA SSQQSSEELS SQLSTVESEK VELVESLSKK EEELAGLGEE
LERVQSSLAS ERESGVKTAE ALQNQLNEKE SREQALESQL VAARWSALQG TVEEAERIVQ
DSLAQLDDPA HISCTSSADY LASRCQASLD CMARLHSARD GYLADNTGVS ELVRAVTHLA
HLVGDTIVQG SATSHMVPVE QADALSDSVK ACGAEALSLL GQMKEQESLA TADGAMLRAA
LDGILATAEK LRPRGLELQQ GELGDLVEQE MAATSAAVES AAARIEDMLN KSRAVDTGVK
MEVNERILAS CTDLMQAIKV LVLSSKDLQR DIVESGRGAA SMKDFYVKNS RWTEGLISAS
KAVGWGATVM VDAADLVVQG KGKYEELMVC SHEIAASTAQ LVAASKVKAD KDNANLGRLK
LASKGVTQAT AGVVASTKSG KSQIEEKDTM DFSSMTLTQI KRQEMDSQVS VLELETKLQK
ERERLGELRK KHYELAGVAE GWGEEDEELV PQTN
//
