ID A0A060WLA7_ONCMY Unreviewed; 179 AA.
AC A0A060WLA7;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=diphosphoinositol-polyphosphate diphosphatase {ECO:0000256|ARBA:ARBA00012527};
DE EC=3.6.1.52 {ECO:0000256|ARBA:ARBA00012527};
GN ORFNames=GSONMT00061170001 {ECO:0000313|EMBL:CDQ67852.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ67852.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ67852.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ67852.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSOMYP00000092260.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=diphospho-myo-inositol polyphosphate + H2O = myo-inositol
CC polyphosphate + phosphate.; EC=3.6.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00033994};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. DIPP subfamily.
CC {ECO:0000256|ARBA:ARBA00008266}.
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DR EMBL; FR904599; CDQ67852.1; -; Genomic_DNA.
DR STRING; 8022.A0A060WLA7; -.
DR PaxDb; 8022-A0A060WLA7; -.
DR Ensembl; ENSOMYT00000100369.2; ENSOMYP00000092260.1; ENSOMYG00000042340.2.
DR GeneTree; ENSGT00940000157882; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR Proteomes; UP000694395; Chromosome 9.
DR GO; GO:0016462; F:pyrophosphatase activity; IEA:InterPro.
DR CDD; cd04666; Nudix_Hydrolase_9; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR047198; DDP-like_NUDIX.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR020084; NUDIX_hydrolase_CS.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR PANTHER; PTHR12629; DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE; 1.
DR PANTHER; PTHR12629:SF5; DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 1; 1.
DR Pfam; PF00293; NUDIX; 1.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS00893; NUDIX_BOX; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380}.
FT DOMAIN 17..144
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
FT REGION 159..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 179 AA; 20251 MW; 64FF81FDDC6B9250 CRC64;
MMKIKSNQTR TYDGDGYKKR AACLCFRNES EEEVLLVSSI RHPGKWIVPG GGMEPEEEPN
VAAVREVCEE AGVKGTLGRL LGIFENTDRK HRTYVYVLIV TEMLEDWEDS VNIGRKREWF
NIEDARRVLQ CHKPVQASYF EALQQGSLSS NGTPLVTTIG GEEHSPTYNI NQSSRSSIR
//
