ID A0A060WSW1_ONCMY Unreviewed; 158 AA.
AC A0A060WSW1;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Insulin-like 3 {ECO:0000256|ARBA:ARBA00014427};
DE AltName: Full=Leydig insulin-like peptide {ECO:0000256|ARBA:ARBA00032881};
DE AltName: Full=Relaxin-like factor {ECO:0000256|ARBA:ARBA00032209};
GN ORFNames=GSONMT00008990001 {ECO:0000313|EMBL:CDQ70468.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ70468.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ70468.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ70468.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Seems to play a role in testicular function. May be a trophic
CC hormone with a role in testicular descent in fetal life. Is a ligand
CC for LGR8 receptor. {ECO:0000256|ARBA:ARBA00025288}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034}.
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DR EMBL; FR904717; CDQ70468.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060WSW1; -.
DR STRING; 8022.A0A060WSW1; -.
DR PaxDb; 8022-A0A060WSW1; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd00101; IlGF_like; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR043387; INSL3/INSL4.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR PANTHER; PTHR10423; INSULIN-LIKE 3; 1.
DR PANTHER; PTHR10423:SF3; INSULIN-LIKE 3; 1.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000193380}.
FT DOMAIN 27..158
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
SQ SEQUENCE 158 AA; 17406 MW; 41A1821E09239AE8 CRC64;
MDAKCLVSLV VVLMVGVYGT HGQDARVKLC GREFIRMVVT SCGSSRLRRS TPELGQHPVN
HHRVILDWLN SNQFSNLRTS ETGEDVVTQQ DDQDSTESMT EDQQTHPGFP STPQVQGDME
PSTVPLGYTV SSRTRRDVGP AGVCCRSGCT MSELVQYC
//
