ID A0A060WYU5_ONCMY Unreviewed; 1178 AA.
AC A0A060WYU5;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=TOG domain-containing protein {ECO:0000259|SMART:SM01349};
GN ORFNames=GSONMT00039748001 {ECO:0000313|EMBL:CDQ72396.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ72396.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ72396.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ72396.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}.
CC -!- SIMILARITY: Belongs to the TOG/XMAP215 family.
CC {ECO:0000256|ARBA:ARBA00025722}.
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DR EMBL; FR904830; CDQ72396.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060WYU5; -.
DR STRING; 8022.A0A060WYU5; -.
DR PaxDb; 8022-A0A060WYU5; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0061863; F:microtubule plus end polymerase; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:InterPro.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:InterPro.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR045110; XMAP215.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR12609:SF0; CYTOSKELETON-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR12609; MICROTUBULE ASSOCIATED PROTEIN XMAP215; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 3.
DR SMART; SM01349; TOG; 4.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..227
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 269..503
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 440..478
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 570..802
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 835..1067
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 243..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1178 AA; 128653 MW; 00D6F894B09D8A2F CRC64;
MGDDSEWMKL PIDQKCEHKV WKARLNGYEE ALKLFKRIED EKSPEWGKYL GLLKKFVTDS
NAVAQLKGLE AALAYIENAH VAGKTSGEVV SGVVSKVFNQ PKARAKELGS DICLMYMEIE
RAEVVQDELI KGLDNKNPKI VVTCIETLRK ALSEFGSKII TLKPVVKVLP KQFESREKAV
RDEAKLLAVE IYKWIRDALR PPLQGINSVQ LKELEEEWVK LPTAAPKQSR FLRSQQALKA
KFEQQQAAGG DEADGDKDDE PAPQVDPYEL LEAVEILSKL PKDFYDKIEA KKWQERKEAL
EAVETLAKNP KLENGDFGDL VRALRKVIGK DANVMLVTLA AKCVAGLAAG LRKKFGTYAG
HVVPTILEKF KEKKPQVVQA LQEAIDAIFL TTTLQNISED VLGVMDNKNP SIKQQASLFL
ARSFRHCTQA TLPKSMLKAF CPAFLKQVND SAPEVRDAAY EALGTAMKVV GEKAVNPFLA
DLDKLKLDKI KESADKVELP GKKGGGVGAE KKAPAAKAAP PAVAPARSSG PPKKAPAAKL
GGPPKKGKPA SAPSAKGKKC PETKEFVETE ISIEVCEERS ATVLPASCMQ LLDSANWKER
LASMEEFQKA VEQMDKSEMP CQALVRMLAK KPGWKETNFQ VMQMKLHIVG LIAQKGSFSK
TSAFVVLDGL VDKIGDVKCG GKAKEGLTAT AEACSLPWTA EQVVSMVFAQ KNPKNQAETL
NWLANAMKEF GFAGINVKGF INNVKTALGA TNPAVRTAAI TLLGVMYLYM GAPLRMFFED
EKPALLKQID DEFEKMQGQS PPTAFRGARK GGAEEDGEEA DEQEEDGGGA PDVMDLLPRT
DISDKITQDM VDKVGDKNWK IRKEGLDEVA AVISEAKFIQ PSIGELPMAL KGRLNDSNKI
LVQQTLTILQ QIAVAMGPAL KQHVKNLGMP IITVLGDGKT NVRAAAMTTL QAWVEQTGMK
DWLEGEDLSE ELKRENPFLR QEVLGWLAEK LPAMRTVPSD LMLCVPYLYS CLEDRNGDVR
KKAQDALPIF MMHLGYEKML KATGKLKPAS KEPVSALLEK ARAVMPAKLA PPPGKAGAAK
SVSGGAPAAK SALSKAKPKP VIDDYDDDDD DDEPEPETKT KKVVKPGAAK KGVLGKKAPV
TKATAKDEED RSGVIFILVP NGKEQRIKEE KGLKASNI
//
