ID A0A060WZF7_ONCMY Unreviewed; 1394 AA.
AC A0A060WZF7;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=D-isomer specific 2-hydroxyacid dehydrogenase catalytic domain-containing protein {ECO:0000259|Pfam:PF00389};
GN ORFNames=GSONMT00024569001 {ECO:0000313|EMBL:CDQ72606.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ72606.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ72606.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ72606.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FR904845; CDQ72606.1; -; Genomic_DNA.
DR STRING; 8022.A0A060WZF7; -.
DR PaxDb; 8022-A0A060WZF7; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR PANTHER; PTHR46221:SF10; FERM AND PDZ DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46221; FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000193380}.
FT DOMAIN 3..74
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT REGION 212..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1124..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..370
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..459
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..659
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..834
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..923
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1020..1036
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1394 AA; 149050 MW; 761CA2A466405EC4 CRC64;
MKVFITRRIP QEGMKILSQA GVCKVSLWDS DEPVPRAELL KGVEGAHGLL CLLSDKINTE
VLEAAGTLEI IWTRLTQTAL LNKAECSPQR XSLSLSLSLC LLHSLARSLS TPPLSLPPLS
LTPLLSLSPP LSLQPFALLM DSLAAKDLAC LLGGYCKLLV DPRVCVFRLG RPKVRVHRIP
AEEGVCEGKF AVIEGVCYES LTSYVSRCCS DSNDSSDEDY PAEPPPTHTR KRHAPASKDR
EGWRREKEEQ RGAEGKKERA EKEDKDKHEV KIIVTSEKDM EVEEEDGRED GGREIHLGGN
ANEGRVEQDM VLDTNWYHTD PRVNSSFSSL SSGSLSAALE ESGVAARGED PAKASSRVDA
LREDSPSRRS KQPTRGIATL DVHHPFLLEV TVPSPQRQRE GAAGSTASAP VRPTNLSYRS
NDSSCLCFAE LSQGSYLPSP PEATSDEEET EEVEDDDDEE ELRRLSKIPS QIDLRLIDKI
CARSNKTASN NKLDIPRIIP NLTSCEKRTV CSSAHKGEER LSIHSGDSEP FLTPSPNPPP
PIARESASES DDEFFDAQER FTPPVPSDGT ENSLDAADNK RHSKRWTGTG NGLPVVPEME
PPSPLKSKHS SPDHKKQQET QRDPKPHSNQ ASTQRVDAKT KPPPLAPKPQ LPIKPELAPK
PQMGPQRSPQ RGGPYSHCNG DAGGGHAGLL EVDTMEPDSM EFKSVTSGAG GHPLASPLIT
AVRRSQQPPA GPQGVENGPK IENSSKNGTH HVLPKDPVLV TADNRRADVE SKTNRVTLLK
GEVRTGVGVD LPKKLPSLSL IPHSASGDEI RLSLATPPPL SPKPSPPSLH PLSVLPIPVS
PNEKEGTCPP SGLHPWVSCN GSNQTGRRVS LSHENLSPKN TDAPLSLTTS LTTSSKGTAG
DPESTGRSGS DLRVSSSSLG GRLPTSALRG RIQALPWYMT RSQEILGTLD HSSTSSINGD
VTSGYGSGLS ISGASEVSKV TAQATVGETA GGKGKKEVVE DGAEVVIATI KEYQEVTPRA
KEANGNSGSH PNLTLRENGA HVSEPYGFLG SCKSEQPQSR PHSEVGLGGG SGPPLEGDSL
EHTPPPAHRE ACGCRTVYAN CFSGDVEDGC GFDEELTIYE FSKRTRPKPA HSTPLASPTS
PIPSPNILSL LRDTPRPLST LSTTSSELSP LLSRPVSPTP PIGSLRSLTN KHYGGLKGGF
VSLRQDINQL LLVLAGPPPS SEPSKTDQDE GASPPPMTEP ERNLLQAEAR RLATGCQRAT
RVGWAPEEAL RSLSNSFSAL VQLSAACLRT HPCPGCDVCR NGGQIQSTDD DGGQEEALDK
LKEIVGLYRE FVGAVETAGA GSGSSSGSGD GQGEGEGVRL LAKRCTVLIS SVFSLTQLFR
THSPDTPGHT PLNF
//
