ID A0A060WZU3_ONCMY Unreviewed; 584 AA.
AC A0A060WZU3;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Frizzled-9 {ECO:0008006|Google:ProtNLM};
GN ORFNames=GSONMT00013921001 {ECO:0000313|EMBL:CDQ70599.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ70599.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ70599.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ70599.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
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DR EMBL; FR904727; CDQ70599.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060WZU3; -.
DR STRING; 8022.A0A060WZU3; -.
DR PaxDb; 8022-A0A060WZU3; -.
DR OrthoDB; 5483535at2759; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd15036; 7tmF_FZD9; 1.
DR CDD; cd07463; CRD_FZ9; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR041777; FZ9_CRD.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF79; FRIZZLED-9; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..584
FT /note="Frizzled-9"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001590051"
FT TRANSMEM 229..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..154
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 229..532
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 149..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 38..99
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 46..92
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 83..121
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 110..151
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 114..138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 584 AA; 65582 MW; 16AEFEAAF921142D CRC64;
MDVFNLRIAI LLWCQLVIVA SSLEIGAYDL ERGRHAKCEP ITIPMCQGIG YNMTRMPNFM
KYASQAEASI KLNEFSPLVE YGCDIHLRFF LCSLYVPMCT DKVSTTIPAC RPMCEQARQK
CSPIMEKFSF GWPDSLDCSK LPTKNDPNSL CMEAPENDTK QETKKGEGML PVPPRPRQPS
SGTSGRSGTS LGSCENPEKF QYVEKSQSCA PRCSSAVDVF WSKKDKDFAF IWMAVWSTLC
FVSTAFTVLT FLLDPQRFQY PERPIIFLSM CYNVYSVAFV IRSVAGAENI ACDRENGELY
IIQEGLESTG CTIVFLILYY FGMASSIWWV ILTLTWFLAA GKKWGHEAIE AHSSYFHMAA
WGIPAMKTIV ILTMRKVAGD ELTGLCYVGS MDVNALTGFV LIPLSCYLVI GTSFILTGFV
ALFHIRKIMK TGGTNTEKLE KLMVKIGVFS ILYTVPATCV IICYFYERLN MDYWKFRVLE
SKCVSFPGRR NEDCSLEESV PTVAVFMLKI FMSLVVGITS GVWVWSSKTL QTWQGLCNRK
LAVRTSRKPC GSVSCSSSHC HYKAPAVVLH MSKTDSYIES PTHV
//
