ID A0A060X5A0_ONCMY Unreviewed; 1397 AA.
AC A0A060X5A0;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Brevican {ECO:0008006|Google:ProtNLM};
GN ORFNames=GSONMT00063163001 {ECO:0000313|EMBL:CDQ72519.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ72519.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ72519.1, ECO:0000313|Proteomes:UP000193380}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; FR904839; CDQ72519.1; -; Genomic_DNA.
DR STRING; 8022.A0A060X5A0; -.
DR PaxDb; 8022-A0A060X5A0; -.
DR Proteomes; UP000193380; Chromosome 2.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0005540; F:hyaluronic acid binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd00033; CCP; 1.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd03517; Link_domain_CSPGs_modules_1_3; 1.
DR CDD; cd03520; Link_domain_CSPGs_modules_2_4; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 3.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000538; Link_dom.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR22804; AGGRECAN/VERSICAN PROTEOGLYCAN; 1.
DR PANTHER; PTHR22804:SF41; BREVICAN CORE PROTEIN; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF00084; Sushi; 1.
DR Pfam; PF07686; V-set; 1.
DR Pfam; PF00193; Xlink; 2.
DR PRINTS; PR01265; LINKMODULE.
DR SMART; SM00032; CCP; 1.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00445; LINK; 2.
DR SUPFAM; SSF56436; C-type lectin-like; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS01241; LINK_1; 2.
DR PROSITE; PS50963; LINK_2; 2.
DR PROSITE; PS50923; SUSHI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT DOMAIN 72..190
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 192..287
FT /note="Link"
FT /evidence="ECO:0000259|PROSITE:PS50963"
FT DOMAIN 288..382
FT /note="Link"
FT /evidence="ECO:0000259|PROSITE:PS50963"
FT DOMAIN 1128..1164
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1177..1291
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 1295..1355
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 437..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 978..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..756
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..866
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 887..904
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 918..934
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1041..1055
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1061..1082
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 238..259
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
FT DISULFID 329..350
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
FT DISULFID 1154..1163
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1297..1340
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1326..1353
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 1397 AA; 154255 MW; AE4719F902EDD8AB CRC64;
MCTGVKRKYL IRYLFQQHHD GKWQLTRLLN GFQTLTNNIN CNLRQPVNFL TQLNPFGLHS
PDDSRLLQVT IPTTPPLSAV LGGSLTLPCL VSLSHPPPNT NGRHAVLSLP RVKWSMLSQG
HETEILVARG DRVKVSEAYK DRASLLHYAS SSADLTLRLD GLQYNDSGFY RCEVQQGLED
ADGVAQVKVK GVVFHYRDAS SRYAFTFAQA RDACEEIGAH IATPEQLLAA YHSGYEQCDA
GWLSDHSVRY PIQMPREGCF GDMDGHPGVR NYGLLEPDEL YDVYCYVENI EGRKICYLLE
SKAYCLAQGA ELATTGQLYA AWNDGLNACS PGWLADGSVR YPIVTPRERC GGGEPGVRTV
YRHLNQTGFP EAHTRHDTYC FRGNSNTHTE SPHDYLATEP EDIGQDIVTL SEPLEEFSLG
QVTEQVMSEE VQGYLTALPI PAEQHPSEHI EEQVAVPGEQ YPEHGAVPGE QYPEQGAVPG
EHGEEQGVVP GEHGEEQEAV PGQHREEQGV HHGEQYPDQP GEEQGAVDGP GPTVVYHEEL
PFPVEPQDPF TPTSFPQDLE PTEDTWHLVK EVSNPESYQP APEEANLDSN YPVTHYDELN
ANPTLYPPSP ETNYESDDLT TAHEDNIGIP DLYQPSLESN MESGEPSIEG VPGTALEAPV
PTTAYEEVDR SSDPHPIPGT TPESGEPTES QYGISEESHM QTEITQETEH YTFTSETTGS
NVSGVEATTS YDSSPEEQLE SRLPIPPEED HSGDEHAIQV EHVTDTVYPS TSYDLSGGSF
RPEGAITGNV EDTSVSSTSP HEETELFPDQ STTQPPYWEN TPEYHQTNSV DHSASVLLPE
EHTTSLDSLV LQTGENSGSA TAESGDLATR SPVEMDPYEL IPTSEYAYDP TQEQSGVTSP
DSSTLDDHVE QEAGGTVDSL PDVSNGSTDQ DEHTDLGSVP TDKVLTVIYD TDSSETSGVH
KVMLDITLLT SPIPITYSPP TQRSVEAGAS SPGDFITVIP ESSVPSGFEP LEEGLEKVEQ
EGLGEIPEVV ETTTPETASG EEGSGDEENG QEVSGEEESG QEASGDEKSG QEASGDEKSX
GRDDPIISVL YFDTIKRGFK NGTHTHTHQQ YFRYVVTAFT LLFSPTFVSD SCHENPCYNG
GTCVDSGSST KCLCLHTYGG HMCQTDLEVC EPGWEKFMGF CYQHFTKRQG WEVAEQHCRM
CGGHLISVMT PEEQNYINDK YREYQWTGLN DRTIEGDFRW SDGNPLLYEN WYRGQPDSYF
LSGEDCVVMV WHDGGRWSDV PCNYHLSYTC KKGTSFCGQP PIIANAKVFG KSRLRYETNS
KVRYYCEEGF LQTQNPVIKC LSNGQWEEAL ITCHPAQTNL AEGEQKVTTP PYQNEGVEVV
DTATEKATSE FWDIKWN
//
